protease/воспаление

Ссылка сохраняется в буфер обмена

Выберите тип сортировки

Страница 1 от 11502 полученные результаты

Inflammation-mediating proteases: structure, function in (patho) physiology and inhibition.

Только зарегистрированные пользователи могут переводить статьи

Войти Зарегистрироваться

Proteases regulating inflammation are versatile enzymes, usually extracellular matrix degrading enzymes that are involved in wound healing, angiogenesis, coagulation, development, apoptosis and other physiological processes. Their dysregulation and increased expression during inflammation can have

Serine protease inhibitors to treat inflammation: a patent review (2011-2016).

Только зарегистрированные пользователи могут переводить статьи

Войти Зарегистрироваться

BACKGROUND Inflammation is a physiological part of the complex biological response of tissues to counteract various harmful signals. This process involves diverse actors such as immune cells, blood vessels, and nerves as sources of mediators for inflammation control. Among them serine proteases are

Increased expression of protease-activated receptor-2 (PAR2) and PAR4 in human coronary artery by inflammatory stimuli unveils endothelium-dependent relaxations to PAR2 and PAR4 agonists.

Только зарегистрированные пользователи могут переводить статьи

Войти Зарегистрироваться

Protease-activated receptor (PAR)1 and PAR2 are expressed on vascular endothelial cells and mediate endothelium-dependent relaxation in several species, and PAR4 agonists cause similar responses in rat aortas. To date, only PAR1 has been reported to mediate relaxation of human arteries despite

Protease-activated receptor 4: a critical participator in inflammatory response.

Только зарегистрированные пользователи могут переводить статьи

Войти Зарегистрироваться

Protease-activated receptors (PARs) are G protein-coupled receptors of which four members PAR1, PAR2, PAR3, and PAR4 have been identified, characterized by a typical mechanism of activation involving various related proteases. The amino-terminal sequence of PARs is cleaved by a broad array of

Neutrophil-targeted, protease-activated pulmonary drug delivery blocks airway and systemic inflammation.

Только зарегистрированные пользователи могут переводить статьи

Войти Зарегистрироваться

Pulmonary drug delivery presents a unique opportunity to target lower airway inflammation, which is often characterized by the massive recruitment of neutrophils from blood. However specific therapies are lacking that can modulate airway neutrophil function, and difficult challenges must be overcome

Role of protease-activated receptors in inflammatory responses, innate and adaptive immunity.

Только зарегистрированные пользователи могут переводить статьи

Войти Зарегистрироваться

Serine proteases are well known as enzymes involved in digestion of dietary proteins, blood coagulation, and homeostasis. Only recent groundbreaking studies revealed a novel role of serine proteases as signaling molecules acting via protease-activated receptors (PARs). Important effects of PAR

Inhibition of NF-kappaB activation and augmentation of IkappaBbeta by secretory leukocyte protease inhibitor during lung inflammation.

Только зарегистрированные пользователи могут переводить статьи

Войти Зарегистрироваться

In earlier experiments, exogenous administration of secretory leukocyte protease inhibitor (SLPI) suppressed acute lung injury induced by deposition of IgG immune complexes. In the current studies we examined the mechanism of the protective effects of SLPI in this model. The presence of SLPI in the

Siropins, novel serine protease inhibitors from gut microbiota acting on human proteases involved in inflammatory bowel diseases.

Только зарегистрированные пользователи могут переводить статьи

Войти Зарегистрироваться

BACKGROUND In eukaryotes, the serpins constitute a wide family of protease inhibitors regulating many physiological pathways. Many reports stressed the key role of serpins in several human physiopathologies including mainly the inflammatory bowel diseases. In this context, eukaryotic serpins were

The neurovascular unit, matrix proteases, and innate inflammation.

Только зарегистрированные пользователи могут переводить статьи

Войти Зарегистрироваться

In the central nervous system, microvessel-neuron interactions appear highly coordinated. The rapid simultaneous responses of the microvasculature, neurons, and glia to focal ischemia in experimental ischemic stroke suggest that these responses could be viewed in a unitary fashion, rather than as

The role of protease activation of inflammation in allergic respiratory diseases.

Только зарегистрированные пользователи могут переводить статьи

Войти Зарегистрироваться

Extracellular endogenous proteases, as well as exogenous proteases from mites and molds, react with cell-surface receptors in the airways to generate leukocyte infiltration and to amplify the response to allergens. Stimulation leads to increased intracellular Ca ++ and gene transcription. The most

The effect of serine protease inhibitors on airway inflammation in a chronic allergen-induced asthma mouse model.

Только зарегистрированные пользователи могут переводить статьи

Войти Зарегистрироваться

Serine protease inhibitors reportedly attenuated airway inflammation and had antioxidant in multiorgan. However, the effects of the serine protease inhibitors nafamostat mesilate (FUT), gabexate mesilate (FOY), and ulinastatin (UTI) on a long-term challenged mouse model of chronic asthma are

Proteases in agricultural dust induce lung inflammation through PAR-1 and PAR-2 activation.

Только зарегистрированные пользователи могут переводить статьи

Войти Зарегистрироваться

Workers exposed to aerosolized dust present in concentrated animal feeding operations (CAFOs) are susceptible to inflammatory lung diseases, such as chronic obstructive pulmonary disease. Extracts of dust collected from hog CAFOs [hog dust extract (HDE)] are potent stimulators of lung inflammatory

IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation.

Только зарегистрированные пользователи могут переводить статьи

Войти Зарегистрироваться

How the innate and adaptive immune systems cooperate in the natural history of allergic diseases has been largely unknown. Plant-derived allergen, papain, and mite allergens, Der f 1 and Der p 1, belong to the same family of cysteine proteases. We examined the role of protease allergens in the

ADAM proteases involved in inflammation are differentially altered in patients with gastritis or ulcer.

Только зарегистрированные пользователи могут переводить статьи

Войти Зарегистрироваться

ADAM metallopeptidase domain (ADAM)9, 10 and 17 have α-secretase activity that regulates ectodomain shedding of factors involved in inflammation, cell proliferation, angiogenesis, and wound healing. The secretase activity of ADAM proteins is known to induce an inflammatory response. However, under

Degradation of basic protein in myelin by neutral proteases secreted by stimulated macrophages: a possible mechanism of inflammatory demyelination.

Только зарегистрированные пользователи могут переводить статьи

Войти Зарегистрироваться

In inflammatory demyelinating diseases such as multiple sclerosis and experimental allergic encephalomyelitis, myelin destruction occurs in the vicinity of infiltrating mononuclear cells. The observations that myelin can be altered prior to phagocytosis and in areas not contiguous with inflammatory

Присоединяйтесь к нашей
странице facebook

Herbal & Natural Medicine

Самая полная база данных о лекарственных травах, подтвержденная наукой

Работает на 55 языках
Травяные лекарства, подтвержденные наукой
Распознавание трав по изображению
Интерактивная карта GPS - отметьте травы на месте (скоро)
Прочтите научные публикации, связанные с вашим поиском
Ищите лекарственные травы по их действию
Организуйте свои интересы и будьте в курсе новостей исследований, клинических испытаний и патентов

Введите симптом или заболевание и прочтите о травах, которые могут помочь, введите лекарство и узнайте о болезнях и симптомах, против которых оно применяется.
* Вся информация основана на опубликованных научных исследованиях.