rheumatic diseases/hypoxia

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[Hypoxia and angiogenesis in rheumatic diseases].

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The important role of angiogenesis for the pathogenesis of most tumors has gained much interest into the mechanisms of new vessel formation during recent years. Hypoxia induces angiogenesis via stabilization of the transcription factor HIF-1alpha. After dimerization of HIF-1alpha with

[Hypoxia is a key factor in the inflammatory milieu of rheumatic diseases].

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Chronic inflammatory diseases are characterized by hypoxia and subsequent cellular adaptation via hypoxia-inducible factor (HIF). Modulation of these adaptation mechanisms provides the basis for ideas on how to improve the effects of known drugs and for the development of novel therapeutic

[Oxygen deficiency in rheumatism].

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Effectiveness and safety of lower dose sulfamethoxazole/trimethoprim therapy for Pneumocystis jirovecii pneumonia in patients with systemic rheumatic diseases: A retrospective multicenter study.

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To evaluate the effectiveness and safety of lower-dose sulfamethoxazole/trimethoprim therapy (SMX/TMP) for Pneumocystis jirovecii pneumonia (PCP) in patients with systemic rheumatic diseases.In this multicenter retrospective study, we compared effectiveness

Cyclosporin A therapy for interstitial pneumonitis associated with rheumatic disease.

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Abstract To determine the efficacy of cyclosporin A (CysA) for the treatment of steroid-resistant interstitial pneumonitis (IP), we enrolled 25 patients with various rheumatic diseases and steroid-resistant IP in a pilot study [4 patients with rheumatoid arthritis (RA), 2 with systemic lupus

Central nervous system involvement in pediatric rheumatic diseases: current concepts in treatment.

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Central nervous system (CNS) manifestations are not rare in pediatric rheumatic diseases. They may be a relatively common feature of the disease, as in systemic lupus erythematosus (SLE) and Behçet's disease. Direct CNS involvement of a systemic rheumatic disease, primary CNS vasculitis, indirect

[The state of cerebral and peripheral hemodynamics in patients with visceral rheumatism].

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In 75 patients with visceral rheumatism prior to and following antirheumatic treatment the authors studied the REG in a frontomastoidal and occipito-mastoidal leading as well as the REG of the brachial muscles. In one group of patients there were REG signs of a significantly increased tone of the

Hypoxia-Inducible Factors (HIFs) in the articular cartilage: a systematic review.

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Osteoarthritis (OA) is the most common joint disease, and in recent years has become a major public health problem. The hallmark of OA is cartilage destruction with local commitment of subchondral bone and the synovial membrane. Hypoxia-inducible factors (HIFs) are transcriptional factors and key

[Changes in the vectorcardiogram in rheumatism with coronary vessel lesions].

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Changes in vectorcardiograms (VCG) taken in 5 projections by the I.T. Akulinichev technique were studied in 101 patients with rheumatic fever involving the coronaries. The VCG changes were found not to be specific of rheumatic coronaritis, but to reflect the degree of coronary insufficiency and

The role of HMGB1 in the pathogenesis of rheumatic disease.

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HMGB1 is a ubiquitous nuclear protein that can be released by any damaged cell or by activated macrophages and certain other cell types. HMGB1 has been successfully therapeutically targeted in multiple preclinical models of infectious and sterile diseases including arthritis. Extracellular HMGB1

Energy metabolism and rheumatic diseases: from cell to organism.

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In rheumatic and other chronic inflammatory diseases, high amounts of energy for the activated immune system have to be provided and allocated by energy metabolism. In recent time many new insights have been gained into the control of the immune response through metabolic signals. Activation of

An emphasis on molecular mechanisms of anti-inflammatory effects and glucocorticoid resistance.

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Glucocorticoids (GC) are universally accepted agents for the treatment of anti-inflammatory and immunosuppressive disorders. They are used in the treatment of rheumatic diseases and various inflammatory diseases such as allergy, asthma and sepsis. They bind with GC receptor (GR) and form GC-GR

[Equilibrium troubles with cervical syndrome and their relation with otorhinolaryngology (author's transl)].

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The equilibrium troubles occuring in connection with cervical locomotoric diseases and their otorhino-laryngologic relations have been studied in the ORL Department of National Institute of Rheumatism and Medical Hydrology. It has been found that: a) there is no connection between the seriousness of

Carpal Tunnel Syndrome in Obstructive Sleep Apnea Patients.

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UNASSIGNED Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy of the upper extremity. It is usually associated with the compression of the median nerve in the median groove. Because the main symptoms of CTS pain and numbness worsen at night, sleep disorders in CTS patients and the

Melittin suppresses HIF-1α/VEGF expression through inhibition of ERK and mTOR/p70S6K pathway in human cervical carcinoma cells.

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OBJECTIVE Melittin (MEL), a major component of bee venom, has been associated with various diseases including arthritis, rheumatism and various cancers. In this study, the anti-angiogenic effects of MEL in CaSki cells that were responsive to the epidermal growth factor (EGF) were

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