8 полученные результаты
FIELD OF THE INVENTION
The invention relates to the use of biologically active glutarimide derivatives or pharmaceutically acceptable salts thereof as agents for the treatment of eosinophilic diseases.
BACKGROUND
Eosinophils are cells of the innate immunity. They are produced in the bone marrow and
TECHNICAL FIELD
This invention relates to methods of preventing or treating diseases or conditions of the lung associated with excessive cell proliferation, remodeling, inflammation, vasoconstriction, bronchoconstriction, airway hyperreactivity and edema. Particularly, this invention relates to
BACKGROUND OF THE INVENTION
Sinonasal complaints affect at least 15% of the population in the United States of America with predictable patient morbidity and financial impact. Importantly, any modality that can alleviate sinonasal complaints warrants serious attention. Among various treatments
This application is related to, not a continuing case to U.S. Pat. Nos. 6,172,060, 6,197,778, 6,177,428, 6,172,068, 6,221,881, 6,232,321, 6,197,782, 6,133,272, and 6,211,179.
FIELD OF THE INVENTION
The present invention describes novel nitrosated and/or nitrosylated phosphodiesterase inhibitors, and
FIELD OF THE INVENTION
The present invention describes novel nitrosated and/or nitrosylated phosphodiesterase inhibitors, and novel compositions comprising at least one nitrosated and/or nitrosylated phosphodiesterase inhibitor, and, optionally, at least one compound that donates, transfers or
FIELD OF THE INVENTION
The present invention describes novel nitrosated and/or nitrosylated phosphodiesterase inhibitors, and novel compositions comprising at least one nitrosated and/or nitrosylated phosphodiesterase inhibitor, and, optionally, at least one compound that donates, transfers or
FIELD OF INVENTION
The invention relates to a compound of formula ##STR1##
wherein R.sup.1 is selected from the group consisting of hydrogen and fluoro. Compounds of formula 1, and pharmaceutically acceptable acid addition salts thereof, have been shown to mediate the Neurokinin 1 (NK-1, substance
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a U.S. National Stage application under 35 U.S.C. .sctn. 371 of International Application PCT/RU2014/000855 (published as WO 2015/072893 A1), filed Nov. 12, 2014, which claims priority to Application RU 2013150861, filed Nov. 14, 2013.