salicylate/инсульт

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A Case of Salicylate Toxicity Presenting with Acute Focal Neurologic Deficit in a 61-Year-Old Woman with a History of Stroke.

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BACKGROUND Over-the-counter medications that contain aspirin are widely used, and patients generally regard them as safe. However, the side effects of salicylate toxicity can be severe, and delay in the diagnosis may increase the risk of mortality. Neurologic symptoms are a common presenting feature

Estimation of hydroxyl radicals based on the salicylate trapping method in hippocampus of stroke-prone spontaneously hypertensive rats (SHRSP) during transient ischemia and recirculation.

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Salicylates and vascular smooth muscle cell proliferation: molecular mechanisms for cell cycle arrest.

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Salicylates are effective prophylactic treatment strategies for myocardial infarction and ischemic strokes. Recent evidence suggests that high doses of salicylates may exert direct, platelet-independent effects on the vascular wall. Salicylate and aspirin, in concentrations between 1 and 5 mM,

Differential hydroxylation of salicylate in core and penumbra regions during focal reversible cerebral ischemia.

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OBJECTIVE Free radical-mediated damage during and/or after cerebral ischemia is thought to participate in the elaboration of stroke-related injury. To elucidate the role of this mechanism in cerebral damage, the study presented herein sought to clarify the spatial and temporal features of the free

An epidemiologic study of abuse of analgesic drugs. Effects of phenacetin and salicylate on mortality and cardiovascular morbidity (1968 to 1987)

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BACKGROUND Phenacetin abuse is known to produce kidney disease; salicylate use is supposed to prevent cardiovascular disease. We conducted a prospective, longitudinal epidemiologic study to examine the effects of these drugs on cause-specific mortality and on cardiovascular morbidity. METHODS In

[Seizures and epilepsies after stroke].

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Epilepsies after stroke represent 20% of all adult-onset epilepsies and exhibit special characteristics with respect to diagnosis, treatment, and prognosis. Patients are frequently amnestic for their seizures the signs of which can be very subtle. Postictal pareses and confusional states can last

Cocaine and salicylate: documentation of hydroxyl radical formation in hearts and brains of 18-day-old chick embryos and unexpected interactive toxicity.

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BACKGROUND Multiple low doses of cocaine (COC) may cause intermittent vasoconstriction and reperfusion, leading to elevations in damaging reactive oxygen species, such as hydroxyl free radicals (*OH). Salicylate may offer protection because it reacts with *OH and/or because of its anti-inflammatory

Incidence of stroke among chronic hemodialysis patients with nonrheumatic atrial fibrillation.

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In general, nonrheumatic atrial fibrillation is associated with a high risk of stroke. However, its impact on stroke in the setting of chronic hemodialysis treatment is insufficiently addressed in the literature. We assessed the incidence of stroke among 430 chronic hemodialysis patients and the

Comparison of the effect of acetylsalicylic acid on platelet function in male and female patients with ischemic stroke.

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The aim of this study was to observe whether acetylsalicylic acid (ASA) had different effects in both sexes. Out of the ischemic stroke patients who were admitted to the National Taiwan University Hospital (NTUH), those who had not taken ASA or ASA-like drugs for more than 2 weeks were selected for

Detection of free radicals by isolated perfusion of the rat brain following hemorrhagic stroke: a novel approach to cerebrovascular biomarker research.

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Blood-borne biomarkers are a mainstay of diagnosis and follow-up in many diseases. For stroke, however, no reliable biomarkers have thus far been identified. To remedy this situation, we investigated the usefulness of a modified in situ isolated brain perfusion (IBP) technique for screening

Reducing the risk: heart disease, stroke and aspirin.

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Aspirin used in cardiovascular disease is probably the best evaluated and the most highly cost effective prophylactic available in clinical practice today. It has been evaluated in over 150 randomised controlled trials and a small daily dose of around 100 mg has been shown to reduce the risk of

Comparison of sodium salicylate, morphine sulfate, and acupuncture at Jen-Chung (Go-26) on the cardiovascular system of dogs.

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The cardiovascular effects of the administration of sodium salicylate (100 mg/kg), the administration of morphine sulfate (0.5 mg/kg) and acupuncture by electrocautery at Jen-Chung (Go-26) were compared in groups of dogs under 0.75% halothane anesthesia. Cardiac output (CO), stroke volume (SV),

Influence of cyclooxygenase-1 genotype on ex vivo aspirin response in patients at risk for stroke.

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BACKGROUND We sought to determine whether cyclooxygenase-1 (PTGS1) genotype is associated with the ability of aspirin to inhibit platelet aggregation in patients at risk for stroke. METHODS Blood and urine samples were collected from 60 subjects, including 28 African Americans, who were taking

Effects of different aspirin formulations on platelet aggregation times and on plasma salicylate concentrations.

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BACKGROUND Early aspirin treatment is widely used to inhibit platelet activity and to reduce morbidity and mortality in patients presenting with an acute myocardial infarction or a stroke. A number of different aspirin formulations have been used for this purpose; however, a comparison of their

Salicylate intoxication in the elderly. Recognition and recommendations on how to prevent it.

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Aspirin (acetylsalicylic acid) and its salicylate derivatives are effective antipyretic, analgesic, and anti-inflammatory agents that are still very widely used by the elderly despite the advent of newer, potentially safer nonsteroidal anti-inflammatory drugs (NSAIDs). However, none of the new

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