Russian
Albanian
Arabic
Armenian
Azerbaijani
Belarusian
Bengali
Bosnian
Catalan
Czech
Danish
Deutsch
Dutch
English
Estonian
Finnish
Français
Greek
Haitian Creole
Hebrew
Hindi
Hungarian
Icelandic
Indonesian
Irish
Italian
Japanese
Korean
Latvian
Lithuanian
Macedonian
Mongolian
Norwegian
Persian
Polish
Portuguese
Romanian
Russian
Serbian
Slovak
Slovenian
Spanish
Swahili
Swedish
Turkish
Ukrainian
Vietnamese
Български
中文(简体)
中文(繁體)
thiophene/воспаление
Ссылка сохраняется в буфер обмена
Страница 1 от 61 полученные результаты
Anti-inflammatory and analgesig thiophene acetic acid derivatives, compositions, and method of use therefor
Только зарегистрированные пользователи могут переводить статьи
Войти Зарегистрироваться
Related compounds are described in French patent No. 2,346,348 and Chem. Abs., Vol. 95 No. 7 (1981) p. 689, No. 61895d.
OBJECTS OF THE INVENTION
It is an object of the invention to provide the novel compounds of formula I and their salts and a novel process and intermediates for their
Anti-inflammatory and analgesic 3-hydroxybenzo[b]thiophene derivatives, compositions, and method of use therefor
Только зарегистрированные пользователи могут переводить статьи
Войти Зарегистрироваться
BACKGROUND OF THE INVENTION
This invention relates to benzothiophenes, particularly 3-hydroxybenzothiophenes, having the 2-carbon side chains, for example, 3-acetoxy-2-butyl-5-chloro-benzo[b]thiophene and its 2-benzyl analog.
These novel benzothiophenes are found to be either specific 5-lipoxygenase
Cyclopenta[b]thiophenes having anti-inflammatory activity similar to steroids
Только зарегистрированные пользователи могут переводить статьи
Войти Зарегистрироваться
Inflammation is a response of mammals to a variety of stimuli including trauma and exposure to temperature extremes as well as disturbances of the immune system resulting in diseases such as rheumatoid arthritis. Modification of the inflammatory response in the treatment of various diseases often
Thiophene compounds for inflammation and immune-related uses
Только зарегистрированные пользователи могут переводить статьи
Войти Зарегистрироваться
RELATED APPLICATION
This application claims the benefit of U.S. provisional application No. 60/646,772, filed on Jan. 25, 2005, the entire teachings of which are incorporated herein by reference.
FIELD OF THE INVENTION
This invention relates to biologically active chemical compounds, namely
Novel thiophene-acetic acids
Только зарегистрированные пользователи могут переводить статьи
Войти Зарегистрироваться
OBJECTS OF THE INVENTION
It is an object of the invention to provide the novel thiophene acetic acid derivatives of formulae I and II.
It is another object of the invention to provide a novel process for the preparation of the thiophene acetic acid derivatives of formulae I and II.
It is an
Novel salt of 5-(benzoyl)-thiophene-2-.alpha.-methyl-acetic acid
Только зарегистрированные пользователи могут переводить статьи
Войти Зарегистрироваться
STATE OF THE ART
Copending, commonly assigned application Ser. No. 610,110 filed Sept. 4, 1975 describes various thiophene-acetic acids and various salts thereof including 5-(benzoyl)-thiophene-2-.alpha.-methyl-acetic acid having analgesic and anti-inflammatory activity but the said acid and its
Derivatives of 3-hydroxyazabenzo(beta)thiophene useful as 5-lipoxygenase inhibitors
Только зарегистрированные пользователи могут переводить статьи
Войти Зарегистрироваться
BACKGROUND OF THE INVENTION
This invention relates to 3-hydroxyazabenzothiophenes having the 2-position substituted with an optionally substituted aryl, aralkyl, alkyl, or alkenyl group, for example, 3-acetyloxy-7-aza-2-phenyl-benzo[b]thiophene.
These novel azabenzothiophenes are found to be either
Derivatives of 3-hydroxyazabenzo(B)thiophene useful as 5-lipoxygenase inhibitors
Только зарегистрированные пользователи могут переводить статьи
Войти Зарегистрироваться
BACKGROUND OF THE INVENTION
This invention relates to 3-hydroxyazabenzothiophenes having the 2-position substituted with an optionally substituted aryl, aralkyl, alkyl, or alkenyl group, for example, 3-acetyloxy-7-aza-2-phenyl-benzo[b]thiophene.
These novel azabenzothiophenes are found to be either
Derivatives of 3-hydroxyazabenzo[b]thiophene useful as 5-lipoxygenase inhibitors
Только зарегистрированные пользователи могут переводить статьи
Войти Зарегистрироваться
BACKGROUND OF THE INVENTION
This invention relates to 3-hydroxyazabenzothiophenes having the 2-position substituted with an optionally substituted aryl, aralkyl, alkyl, or alkenyl group, for example, 3-acetyloxy-7-aza-2-phenyl-benzo[b]thiophene.
These novel azabenzothiophenes are found to be either
Thiophene nitrone compounds
Только зарегистрированные пользователи могут переводить статьи
Войти Зарегистрироваться
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to novel thiophene nitrone compounds and their use as therapeutic agents and analytical reagents. More particularly, this invention concerns novel thiophene nitrone compounds and their use as therapeutics for treating
Thiophenes and uses thereof
Только зарегистрированные пользователи могут переводить статьи
Войти Зарегистрироваться
BACKGROUND OF THE INVENTION
Phosphatidylinositol 3-kinase (PI3K) is a family of lipid kinases that phosphorylate phosphatidylinositol at the 3' position of the inositol ring. PI3K is comprised of several classes of genes, including Class IA, IB, II and III and some of these classes contain several
Thiophene-2-carboxamidotetrazoles and pharmaceutical use thereof
Только зарегистрированные пользователи могут переводить статьи
Войти Зарегистрироваться
BACKGROUND OF THE INVENTION
This invention relates thiophene-2-carboxamidotetrazoles which inhibit the effects of the Mac-1 leukocyte molecule, and as such are useful for treating diseases mediated thereby, including inflammatory disorders.
Leukocyte-endothelial interactions are involved in the
Tricyclic fused thiophene derivatives as JAK inhibitors
Только зарегистрированные пользователи могут переводить статьи
Войти Зарегистрироваться
TECHNICAL FIELD
The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory
Tricyclic fused thiophene derivatives as JAK inhibitors
Только зарегистрированные пользователи могут переводить статьи
Войти Зарегистрироваться
TECHNICAL FIELD
The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory
Tricyclic fused thiophene derivatives as JAK inhibitors
Только зарегистрированные пользователи могут переводить статьи
Войти Зарегистрироваться
TECHNICAL FIELD
The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory
Самая полная база данных о лекарственных травах, подтвержденная наукой
- Работает на 55 языках
- Травяные лекарства, подтвержденные наукой
- Распознавание трав по изображению
- Интерактивная карта GPS - отметьте травы на месте (скоро)
- Прочтите научные публикации, связанные с вашим поиском
- Ищите лекарственные травы по их действию
- Организуйте свои интересы и будьте в курсе новостей исследований, клинических испытаний и патентов
Введите симптом или заболевание и прочтите о травах, которые могут помочь, введите лекарство и узнайте о болезнях и симптомах, против которых оно применяется.
* Вся информация основана на опубликованных научных исследованиях.
