[General cerebral and systemic metabolic disturbances occurring in ischemic stroke with special emphasis on glucose and its metabolites].

Ischaemic stroke is a stressogenic factor triggering a complex defensive reaction called "alarm reaction" by Selye. Stress gives rise to liberation of catecholamines, dopamine beta-hydroxylase in the blood, cerebro-spinal fluid and urine. Patients with ischaemic stroke were found to have increased adrenaline, noradrenaline, and 3-metoxy-4-hydroxymandelic acid level in urine and increased cortisol level in blood serum. Patients, especially those with severe ischaemic stroke have increased concentrations of glucose metabolites in blood and cerebro-spinal fluid: pyruvate acid, lactic acid, acetylacetic acid and hydroxybutyric acid.