Farmakologiia i toksikologiia
[Search for anti-inflammatory preparations among the derivatives of succinic acid heteryl amides].
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Abstrakt
The antiinflammatory activity and acute toxicity of 44 derivatives of heteryl amides of succinic acid (acids, esters, amides) were studied. This series of compounds was found to be promising for the search of nonsteroidal, practically nontoxic antiphlogistics. The structural-pharmacological analysis was performed and the dependence of the biological effect on the compound structure was revealed.
