[The effect of polarizing mixture KIG (potassium + insulin + glucose) on some metabolites of glucose transformation in patients with ischemic stroke during the earliest period of illness].

The purpose of the study was to investigate the effect of polarizing mixture on the level of lactic and pyruvic acids in blood and cerebro-spinal fluid of patients with acute ischaemic stroke in the earliest phase of illness. The investigation was done in 20 patients with completed stroke and 16 with TIA, which were treated with polarizing mixture. The diminution of the level of lactic acid in blood and cerebro-spinal fluid near to normal values was found in patients with completed stroke after treatment with intravenous infusions of polarizing mixture, but the level of pyruvic acid in body fluids mentioned above was increased in unsteady way after this treatment. The concentrations of lactic and pyruvic acids in blood of patients with TIA after treatment with polarizing mixture in the first twenty-four hours of illness were insignificantly elevated in comparison with the control group. The significant diminution of the lactate/pyruvate ratio in cerebro-spinal fluid found in patients with completed stroke treated with polarizing mixture may be an index of reduction of lactic acid cedemogenic effect on the brain.