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Transferrin directed delivery of adriamycin to human cells.

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Transferrin was covalently conjugated to adriamycin (Trf-adr) by the formation of a schiff base. This conjugate was found to bind to cell membrane trf receptors in a variety of human tumor cell lines. The Trf-adr conjugate was found to be active against sensitive and resistant cell lines e.g. Lovo,

[New management of brain neoplasms. 2. Local injection of adriamycin].

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This is the second paper on a trial treatment of malignant brain tumors by postoperative intracavity chemotherapy. In 34 patients with malignant brain tumors in cerebral hemispheres, 0.5 mg adriamycin (ADM) was injected through an Ommaya's device into the tumor-bed every other day after subtotal

[The effect of whole pleural cavity irradiation with combined 60Co and electron beam plus local biological agents on malignant pleural effusion].

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BACKGROUND To study the effect and complications of combined 60Co γ ray and electron beam irradiation to malignant pleural effusion. METHODS From January,1996 to December,1998,55 patients with malignant pleural effusion (unilateral; 49 cases of primary lung cancer,4 breast cancer and 2 thymic tumor)

[Anthracycline derivatives as photosensitizing agents in photodynamic laser therapy: an in vitro study with squamous epithelial cancer cells of the mouth cavity].

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Photodynamic laser therapy performed with hematoporphyrin derivatives has become increasingly important in the treatment of well-defined tumors in superficial sites. Limitations of this procedure result from the side effects of hematoporphyrin derivatives. In searching for possible alternatives to

[Non-Hodgkin's lymphoma of the nasal cavity and paranasal sinuses: clinicopathologic study of ten cases].

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Ten patients with non-Hodgkin's lymphoma originated in the nasal cavity (four patients) and in the paranasal sinuses (six patients) were treated mainly with irradiation and combination chemotherapy including adriamycin. According to the TNM AJC staging system, four patients were in stage T1-T2, and

[Intracranial and orbital extension of a nasal cavity adult T-cell leukemia: a case report].

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Adult T-cell leukemia (ATL) is one kind of leukemia induced by human T lymphotropic virus type I (HTLV-I) infection. An unusual case of ATL is presented. A fifty-one-year-old male patient was admitted to our hospital because of nasal obstruction and blindness in the left eye. Imaging study revealed

Esophageal atresia and other visceral anomalies in a modified Adriamycin rat model and their correlations with amniotic fluid volume variations.

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The Adriamycin rat model (ARM) has been used to produce visceral malformations in fetuses to explain the mechanisms of foregut division. The models vary in the dosage of Adriamycin (ADR) and in the number of applications. Our study of a modified ARM using 2.2 mg/kg of ADR for 2 days only,

[A case of huge omental-origin liposarcoma controlled by a combination of ifosfamide and adriamycin].

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A 51-year-old woman came to our hospital after a medical check -up. She suffered from abdominal distension. Abdominal CT revealed the abdominal cavity filled with omental cake. The preoperative diagnosis was unassertive. Laparotomy through midline incision was performed. The bulk of the omental

[Local administration of adriamycin (ADM) for malignant pleural effusion and pericardiac effusion in breast cancer].

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We examined the efficacy, toxicity, and survival rate of patients treated with local administration of adriamycin (ADM) for malignant pleural effusion and pericardial effusion in breast cancer. From May 1996 to December 2002, we injected ADM into the pleural cavity for 21 courses and into the

Effects of administered route on tissue distribution and antitumor activity of polyethyleneglycol-coated liposomes containing adriamycin.

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Tissue distribution, antitumor activity and side effects after intraperitoneal administration of polyethyleneglycol-coated liposomes containing adriamycin (PEG-LADR) were examined and compared to that after intravenous treatment. Plain liposomes (PLADR) and PEG-LADR appeared to maintain blood

Pathologic features of adriamycin toxicosis in young pigs: nonskeletal lesions.

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In ten experiments, 53 castrated male 4- to 8-week-old weanling pigs were given adriamycin (ADR) IV at mean dosages of 0.64, 1.0, 1.6, 3.2, or 6.4 mg/kg/week at various frequencies for up to 20 weeks. Mortalities in pigs given these dosages were 0% after 112 days, 100% after 134 days (survival time

[A case of sarcomatoid malignant peritoneal mesothelioma responding to combination chemotherapy of cyclophosphamide, vincristine, adriamycin and dacarbazine(CYVADIC)].

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A 66-year-old woman was seen at our hospital because of abdominal fullness. A computed tomography(CT)revealed massive tumors in abdominal cavity. The patient underwent surgery consisting of tumorectomy, segmental gastrectomy, partial resection of small intestin, transverse colectomy, left

[A preliminary clinical observation of giant cell tumor of bone treated by adriamycin-loaded chitosan drug delivery system].

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In order to observe the curative effect and general reaction of locally used adriamycin (ADM)-loaded chitosan drug delivery system on giant cell tumor of bone after curettage. The cavities of 4 cases of giant cell tumor after curettage were filled with ADM-loaded chitosan drug delivery system with 4

Effect of route administration and liposome entrapment on the metabolism and disposition of adriamycin in the rat.

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The plasma clearance, tissue distribution, metabolism, and excretion of free Adriamycin (Adr) and liposome-entrapped Adr (Adr/L) was examined after iv and ip administration to rats. When given iv, free Adr was cleared more rapidly from plasma than was Adr/L. In contrast, Adr and Adr/L were cleared

Adriamycin induces exocytosis in rat and beige mouse peritoneal mast cells: an ultrastructural, morphometric and biochemical study.

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The process of exocytosis was studied in rat and beige mouse peritoneal mast cells stimulated by adriamycin (ADR) at 37 degrees C and 22 degrees C. ADR induces a non cytotoxic histamine release that is followed by a significant uptake of the drug. Examination was performed by transmission electron

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