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Strana 1 od 27 výsledky
[β-aescin alleviates acute lung injury induced by lipopolysaccharide by inhibiting lipid peroxidation and inflammation in mice].
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Objective To study the protective effect of β-aescin on lipopolysaccharide (LPS) induced-acute lung injury (LPS-ALI) and to explore the underlying mechanism. Methods Sixty male C57BL/6 mice were randomly divided into four groups including normal control group, β-aescin-treated group, LPS-ALI group,
Aescin protection of human vascular endothelial cells exposed to cobalt chloride mimicked hypoxia and inflammatory stimuli.
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Human vascular endothelial cells (HUVECs) were exposed to CoCl2 as an in vitro model of hypoxia. Expression of VCAM-1 (vascular cell adhesion molecule), reduction of PECAM-1 (platelet endothelial cell adhesion molecule) and cytoskeletal changes without alterations in cell viability were observed.
[On the effect of aescin and flavonoid complex from horse chestnut on inflammatory edema].
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[The anti-edematous and anti-inflammatory effects of aescin its relation to the hypophyseal-adrenal system].
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[Biochemistry of inflammation and edema formation as well as pharmacokinetics of aescin].
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[Impact of combined therapy using glucosamine sulfate and anti-inflammatory agent on pain severity in patients with osteoarthritis: prospective, non-controlled postmarketing study].
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Pain is one of the major symptoms of the osteoarthritis (OA). The objective of the study was to evaluate impact of combined therapy with diclofenac, aescin and original glucosamine sulfate on pain severity in patients with OA of different localizations in real life clinical settings in Russia and
The novel role of β-aescin in attenuating CCl4-induced hepatotoxicity in rats.
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BACKGROUND
β-Aescin has anti-inflammatory, anti-oxidant and antiedematous properties.
OBJECTIVE
The present study investigated the hepatoprotective effect and underlying mechanisms of β-aescin in CCl4-induced liver damage.
METHODS
Thirty-five Wistar rats were divided into six groups: normal control,
Temperature dependent self-organization of DMPC membranes promoted by intermediate amounts of the saponin aescin.
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The plant-derived biosurfactant aescin is naturally present in many plants and is used for treatment of disorders such as varicose veins and inflammation of veins. The hemolytic activity of this saponin is attributed to its interaction with cholesterol in the red blood cell membrane. This work
Successful treatment of pachydermoperiostosis patients with etoricoxib, aescin, and arthroscopic synovectomy: Two case reports.
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BACKGROUND
Pachydermoperiostosis (PDP) is a rare hereditary disorder that affects the skin and bones. PDP is characterized by periostosis, digital clubbing, and pachydermia. Previous studies demonstrated that increased prostaglandin E2 (PGE2) levels resulting from defective protein degradation
Sodium beta-aescin may be an effective therapeutic agent for Bell's palsy.
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Although Bell's palsy is the most common acute facial paralysis, the cause of it is still unknown. This made the treatment for it remain very limited. Many methods are simply symptomatic treatment. Up to now we have known that Bell's palsy is related to viral infection and the pathomechanism of
Corticosteroid transdermal delivery to target swelling, edema and inflammation following facial rejuvenation procedures.
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OBJECTIVE
The use of transdermal therapeutic systems has spread worldwide since they allow effective local drug delivery. In the present study, we investigated the efficacy and safety of a new betamethasone valerate medicated plaster (Betesil®) to manage facial swelling, edema, inflammation,
Aescin Incorporation and Nanodomain Formation in DMPC Model Membranes.
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The saponin aescin from the horse chestnut tree is a natural surfactant well-known to self-assemble as oriented-aggregates at fluid interfaces. Using model membranes in the form of lipid vesicles and Langmuir monolayers, we study the mixing properties of aescin with the phase-segregating
Occupational asthma related to aescin inhalation.
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BACKGROUND
More than 400 agents are recognized as causes of occupational asthma, a work-related disease that can be induced by an immunologic or a nonimmunologic mechanism.
OBJECTIVE
To describe a 57-year-old man employed in the pharmaceutical industry who developed bronchial asthma while working
Aescin reduces oxidative stress and provides neuroprotection in experimental traumatic spinal cord injury.
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Aescin has many physiological functions that are highly relevant to spinal cord injury (SCI), including anti-inflammation, anti-oxidation, anti-oedema, and enhancing vascular tone. The present study investigated the putative therapeutic value of aescin in SCI, with a focus on its neuroprotective,
Effects of aescin on cytochrome P450 enzymes in rats.
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BACKGROUND
Aescin, the main active component found in extracts of horse chestnut (Aesculus hippocastanum) seed a traditional medicinal herb, is a mixture of triterpene saponins. It has been shown to be effective in inflammatory, chronic venous and edematous treatment conditions in vitro and in vivo,
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