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Novel 2-thienyloxyacetic acid derivatives, a process for their preparation and pharmaceutical preparations containing them

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DESCRIPTION The invention relates to novel 2-thienyloxyacetic acid derivatives, a process for their preparation and pharmaceutical preparations containing these substances. Substances with an antithrombotic action have already been known for a relatively long time. Thus, for example, acetylsalicylic

Aza-amino acid derivatives (factor Xa inhibitors 15)

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The invention relates to semicarbazides of the general formula I, ##STR2## where: R.sup.1 is --(CH.sub.2).sub.n --NH.sub.2, --CON.dbd.C(NH.sub.2).sub.2, --NHC(.dbd.NH)--NH.sub.2 or --C(.dbd.NH)--NH.sub.2, which can also be monosubstituted by --OH, --OCOOA, --OCOO(CH.sub.2).sub.n N(A).sub.2,

Imidazopyridines and related derivatives as selective modulators of bradykinin B2 receptors

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FIELD OF THE INVENTION This invention relates to certain imidazopyridines and related azacyclic derivatives which when appropriately substituted are selective modulators of Bradykinin B.sub.2 receptors. This invention also relates to pharmaceutical compositions comprising such compounds. It further

Substituted imidazoles as selective modulators of Bradykinin B2 receptors

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FIELD OF THE INVENTION This invention relates to certain imidazoles which, when appropriately substituted, are selective modulators of Bradykinin B.sub.2 receptors (BK-2 receptors). This invention also relates to pharmaceutical compositions comprising such compounds. It further relates to the use of

Aryl and hetroaryl fused aminoalkyl-imidazole derivatives: selective modulators of bradykinin B2 receptors

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BACKGROUND OF THE INVENTION 1. Field of the Invention This invention relates to aryl and heteroaryl fused aminoalkylimidazole derivatives which, when appropriately substituted, are selective modulators of Bradykinin B.sub.2 receptors. This invention also relates to pharmaceutical compositions

Substituted biphenyl derivatives

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The invention relates to compounds of the formula I ##STR2## in which: R.sup.1 is: phenyl or naphthyl, which is substituted by --C(.dbd.NH)NH.sub.2, that can also be monosubstituted by --COA, --CO--[C(R.sup.7).sub.2 ].sub.n -Ar', --COOA, --OR.sup.7, --OCOA, --OCO--[C(R.sup.7).sub.2 ].sub.n -Ar' or

Polynucleotides that encode the calcitonin gene-related peptide receptor coponent factor (HOUNDC44)

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FIELD OF THE INVENTION This invention relates, in part, to newly identified polynucleotides and polypeptides; variants and derivatives of the polynucleotides and polypeptides; processes for making the polynucleotides and the polypeptides, and their variants and derivatives; agonists and antagonists

1,8-naphthyridin-2-one derivative and use thereof

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TECHNICAL FIELD This application is the national phase of ACT/JP92/01575 filed Dec. 1, 1992. The present invention relates to 1,8-naphthyridin-2-one derivatives, pharmaceutically acceptable acid addition salts and therapeutic agents for the diseases such as peripheral diseases (e.g. hypertension,

Nitrile derivatives that inhibit cathepsin K

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BACKGROUND OF THE INVENTION 1. Field The present invention relates to novel nitrile derivatives, their manufacture and use as medicaments. In particular, the invention relates to novel nitrile derivatives of formula (I) 2. Description Cysteine proteases have been viewed as lysosomal mediators of

Heteroaryl nitriles

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BACKGROUND OF THE INVENTION Cysteine proteases have been viewed as lysosomal mediators of terminal protein degradation. Several newly discovered members of this enzyme class, however, are regulated proteases with limited tissue expression, which implies specific roles in cellular physiology and thus

Beta-amino acid nitrile derivatives as cathepsin K inhibitors

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FIELD OF THE INVENTION The present invention relates to novel beta-amino acid nitrile derivatives, their manufacture and use as medicaments. In particular, the invention relates to novel beta-amino acid nitrile derivatives of formula (I) ##STR1## wherein R.sup.1 represents hydrogen, aryl,

Derivatives of thiophene-2-carboxylic acid and their pharmaceutically acceptable acid or base addition salts and use in treatment of conditions caused by thromboxane A.sub.2

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SUMMARY OF INVENTION The present invention relates to novel therapeutically useful derivatives of the thiophene-2-carboxylic acid of the general formula ##STR2## in which R in position 3 or 4 is hydrogen, methyl, chlorine or bromine and R.sub.1 is hydrogen or C.sub.1 -C.sub.4 -alkyl, and the

Human protein kinase HOACF72

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FIELD OF INVENTION This invention relates to newly identified polynucleotides, polypeptides encoded by them and to the use of such polynucleotides and polypeptides, and to their production. More particularly, the polynucleotides and polypeptides of the present invention relate to a protein

Human protein kinase HOACF72

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FIELD OF THE INVENTION This invention relates to newly identified polynucleotides, polypeptides encoded by them and to the use of such polynucleotides and polypeptides, and to their production. More particularly, the polynucleotides and polypeptides of the present invention relate to a protein

Human protein kinases hYAK3

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