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The role of antipsychotics in the management of fibromyalgia.

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Fibromyalgia is a syndrome characterized by chronic generalized pain associated with different somatic symptoms, such as sleep disturbances, fatigue, stiffness, balance problems, hypersensitivity to physical and psychological environmental stimuli, depression and anxiety. It has been estimated to

Behavioural tests of the dopamine depletion hypothesis of neuroleptic-induced response decrement.

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This study was carried out to test the hypothesis that neuroleptic-induced within-session response decrements reflect a fatigue process, resulting from dopamine depletion, that is present before the session begins but is masked briefly by activational cues present at the start of the session.

Safety and tolerability of once monthly aripiprazole treatment initiation in adults with schizophrenia stabilized on selected atypical oral antipsychotics other than aripiprazole.

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OBJECTIVE Safety and tolerability assessment of initiating treatment with a once monthly long-acting injectable form of aripiprazole (aripiprazole once monthly) in patients stabilized on oral antipsychotics other than aripiprazole. METHODS Patients with schizophrenia treated with oral atypical

Neuroleptic malignant syndrome variant in a patient receiving donepezil and olanzapine.

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BACKGROUND A 78-year-old man with a 22-year history of schizoaffective disorder and a 5-year history of dementia presented to the emergency department with a 5-day history of fatigue, progressive weakness, confusion and lethargy, and a 1-day history of severe muscle stiffness. For the past 10 years

[Fatigue, breathlessness and chest pain in a 31-year-old man with schizoaffective disorder].

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Clozapine is an alternative antipsychotic medication used to control symptoms of schizophrenia and to reduce risks of suicidal behavior in patients who did not adequately respond to standard medication. Due to severe side effects including cardiomyopathy and myocarditis its clinical

Analysis of Adverse Drug Reactions of Atypical Antipsychotic Drugs in Psychiatry OPD.

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BACKGROUND Novel atypical antipsychotics are superior to conventional antipsychotics as they significantly reduce both positive and negative symptoms of schizophrenia and have lower risk of extrapyramidal symptoms (EPS). However, these drugs have separate set of adverse drug reactions (ADRs).

Factors associated with fatigue in breast cancer patients undergoing external beam radiation therapy

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Purpose: Cancer-related fatigue (CRF), a prevalent symptom among cancer patients, is a side effect of external beam radiotherapy (EBRT). Even when targeting organs unrelated to caloric intake or the CNS, radiotherapy can increase CRF, a

Mediators of inflammation and their interaction with sleep: relevance for chronic fatigue syndrome and related conditions.

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In humans, activation of the primary host defense system leads to increased or decreased NREM sleep quality, depending on the degree of early immune activation. Modest elevations of certain inflammatory cytokines are found during experimental sleep loss in humans and, in addition, relatively small

Chronic fatigue syndrome associated with a psychotic state resulting in multiple murders.

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A 28-year-old, ambitious, academically successful Asian man with a zeal for hard work develops infectious mononucleosis and its resultant lethargy and fatigue. He becomes depressed, then develops symptoms of mania before turning floridly psychotic. In his psychotic state he develops grandiose

A review of modafinil and armodafinil as add-on therapy in antipsychotic-treated patients with schizophrenia.

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Schizophrenia is characterized by reality distortion, psychomotor poverty and cognitive disturbances. These characteristics contribute to a lesser social functioning and lower quality of life in patients with schizophrenia. It has been suggested that modafinil and its isomer armodafinil as an add-on

Circadian pattern of acute, neuroleptic-induced dystonic reactions.

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OBJECTIVE This study examined the timing of acute dystonic reactions in 200 patients taking neuroleptic medication for the first time. METHODS Two hundred patients received a twice-daily regimen of low-dose neuroleptic. RESULTS Over 80% of the episodes of acute dystonia occurred between 12:00 noon

Efficacy and tolerability of clozapine in Japanese patients with treatment-resistant schizophrenia: results from a 12-week, flexible dose study using raters masked to antipsychotic choice.

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Japan approved clozapine for treatment-resistant schizophrenia in June 2009. The aim of this study was to evaluate clozapine's efficacy and tolerability in Japanese patients. A twelve-week, single-arm clinical trial of clozapine in treatment-resistant schizophrenia inpatients, was conducted under

[Sleep quality and daytime sleepiness in schizophrenia spectrum disorders during antipsychotic treatment].

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OBJECTIVE Patients with schizophrenia frequently report disturbed sleep and excessive daytime sleepiness. In this study the sleep quality and daytime sleepiness of patients hospitalized due to psychotic disorders was assessed shortly before the discharge from the hospital. METHODS 62 patients

Usefulness of interim analyses in portending study results in antipsychotic and antidepressant trials.

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It is unknown whether interim analyses portend final study results. Fatigue, pressure to complete trials and recruitment differences may mitigate against this. We examined the similarity of efficacy results of the first and second half of recruited patients to complete trials and explore possible

Control of simultaneous movements distinguishes depressive motor retardation from Parkinson's disease and neuroleptic parkinsonism.

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Patients with depressive motor retardation, neuroleptic induced parkinsonism or Parkinson's disease were tested on movement tasks requiring control of simultaneous movements. This was in order to determine whether these three groups of patients, who all show slowing of movements, also share the

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