antipsychotics/hemorrhage

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Gastrointestinal bleeding and massive liver damage in neuroleptic malignant syndrome.

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BACKGROUND Neuroleptic malignant syndrome (NMS) is a rare side effect of antipsychotic therapy characterized by fever, muscular rigidity, altered mental status, increased level of serum creatinine phosphokinase, and increased number of white blood cells. The mortality rate of patients with NMS

Neuroleptic malignant syndrome complicated by massive intestinal bleeding in a patient with chronic renal failure.

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A patient with chronic renal failure (CRF) developed neuroleptic malignant syndrome (NMS) after administration of risperidone and levomepromazine. In addition to the typical symptoms of NMS, massive intestinal bleeding was observed during the episode. This report suggests that NMS in a patient with

Torsade de pointes complicating the treatment of bleeding esophageal varices: association with neuroleptics, vasopressin, and electrolyte imbalance.

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Torsade de pointes is an unusual life-threatening ventricular arrhythmia that has been associated with vasopressin, neuroleptic drugs, and electrolyte imbalances, including hypokalemia and hypomagnesemia. Over a 9-month period, we observed torsade de pointes in three patients with cirrhosis and

Antipsychotic Use Among 1144 Patients After Aneurysmal Subarachnoid Hemorrhage.

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Background and Purpose- At acute phase and neurointensive care, patients with aneurysmal subarachnoid hemorrhage (aSAH) may become agitated or delirious. We found no previous studies on psychotic disorders or antipsychotic drug (APD) use by long-term aSAH survivors. We defined the APD use and its

[Peridural anesthetic block completed with NLA with neuroleptic dominance. Its ability to prevent the irreversibility of experimental hemorrhagic shock].

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Neuroleptic malignant syndrome associated with basal ganglia hemorrhage.

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[A neuroleptic malignant syndrome complicated by subarachnoid hemorrhage and revealing cerebral vasculitis].

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Cardiovascular risk assessment of atypical antipsychotic drugs in a zebrafish model.

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The zebrafish model has been developed and evaluated for its ability to predict the toxicity of chemicals. Zebrafish additionally serve as an excellent model for assessing drug-induced cardiotoxicity, although zebrafish and mammalian hearts differ in structure. Recently, regulatory authorities have

Use of serotonergic drugs and the risk of bleeding.

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We assessed several classes of serotonergic drugs in order to evaluate whether they constitute a risk factor for hospitalization for bleeding (gastrointestinal, intracranial, or in the female genital tract). A case-control study was conducted using data from the PHARMO record linkage system (RLS).

[Paroxetine-induced neuroleptic malignant syndrome].

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We report on a 22-year-old schizophrenic patient who attempted suicide and suffered an epidural hemorrhage. 16 days after the neurosurgical operation. After several weeks of treatment with promethazine, 1 day after intake of paroxetin he partially lost consciousness and developed extrapyramidal

Multiple intracerebral hemorrhages in an elderly patient after adding quetiapine to a stable warfarin regimen.

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The efficacy of antipsychotics in patients with dementia exhibiting psychiatric symptoms has been overshadowed by safety concerns in recent years. Evidence suggests that the long-term use of antipsychotics in older adults is associated with a greater risk of cerebrovascular adverse events than

Bilateral Basal Ganglion Hemorrhage after Severe Olanzapine Intoxication

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Olanzapine is a second-generation antipsychotic drug which is generally considered safe with well therapeutic antipsychotic effects. We describe a patient suffering from bilateral intracerebral hemorrhage after severe olanzapine intoxication without underlying thrombocytopenia, arterial

Thrombocytopenia and Spontaneous Intracranial Hemorrhage After Olanzapine Therapy.

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The use of atypical antipsychotics in the United States has increased over the past decade, since atypical antipsychotics such as olanzapine and clozapine were introduced. Of the adverse effects associated with olanzapine, bone marrow suppression is one of the most common, but spontaneous

An assessment of periodontal health in patients with schizophrenia and taking antipsychotic medication.

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OBJECTIVE Severe periodontal disease is prevalent among patients with schizophrenia and is caused by the side effect of their medication, poor dental hygiene and smoking. The objective of this study was to evaluate whether the rate of periodontal disease could be modulated by changing the salivary

U-74500A (lazaroid), a 21-aminosteroid attenuates neuroleptic-induced orofacial dyskinesia.

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21-Aminosteroid, or lazaroid, is one of a novel class of antioxidant drugs designed to inhibit iron-dependent lipid peroxidation in biological lipid environments. They have shown promising results in several animal models of traumatic, ischemic and hemorrhagic injury of the central nervous system.

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