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Studies on the animal model of post-stroke depression and application of antipsychotic aripiprazole.

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We investigated the question of whether an animal model of post-stroke depression in ischemic stroke can be developed by additional chronic mild stress (CMS) procedures. Behavioral and histopathological analysis was performed for examination of the depressive disorders in CMS, left middle cerebral

Antipsychotic drugs increase the risk of stroke for people with dementia.

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Behavioural and psychological symptoms, including agitation, psychosis, depression and aggression, occur in up to half of those with dementia in the community and in an even higher proportion of those in residential care. Antipsychotic drugs have been widely prescribed for these symptoms but have

The explanatory role of stroke as a mediator of the mortality risk difference between older adults who initiate first- versus second-generation antipsychotic drugs.

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Antipsychotic drugs are used to treat dementia-related symptoms in older adults, and observational studies show higher risks of death and stroke associated with the use of first-generation antipsychotic drugs (FGAs) compared with second-generation antipsychotic drugs (SGAs). However, the extent to

[Anesthetic management of a patient with mental disabilities as well as the past history of heat stroke and neuroleptic malignant syndrome].

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A 22-year-old man with mental disabilities with the history of neuroleptic malignant syndrome and heat stroke was scheduled for dental treatment under general anesthesia. Heat stroke and neuroleptic malignant syndrome are related to malignant hyperthermia. We suggested the patient and family to

Meta-analysis of population-based studies comparing risk of cerebrovascular accident associated with first- and second-generation antipsychotic prescribing in dementia.

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Second-generation antipsychotics (SGAs) are often prescribed in the treatment of Behavioral and Psychological Symptoms of Dementia (BPSD), however, their use has been discouraged in light of clinical trials suggesting that they cause an increased risk of cerebrovascular accidents (CVAs). Aim of the

Post-stroke mortality, stroke severity, and preadmission antipsychotic medicine use--a population-based cohort study.

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OBJECTIVE It has been suggested that antipsychotic medication may be neuroprotective and may reduce post-stroke mortality, but studies are few and ambiguous. We aimed to investigate the post-stroke effects of preadmission antipsychotic use. METHODS We conducted a nationwide, population-based cohort

Association of stroke with the receptor-binding profiles of antipsychotics-a case-crossover study.

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BACKGROUND Previous research suggests a link between antipsychotic use and stroke, but the relationships between receptor-binding profiles of antipsychotics and the risk of cerebrovascular events are unclear. METHODS A total of 14,584 patients with incident stroke were enrolled in the National

Age, antipsychotics, and the risk of ischemic stroke in the Veterans Health Administration.

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OBJECTIVE Time-dependent effects of antipsychotics on risk of stroke and potential effect modification by age have not been fully investigated. A case-case-time-control design uses within- and between-case comparisons to evaluate short-term effects at the same time as adjusting for unmeasured

Second-generation antipsychotics and risk of cerebrovascular accidents in the elderly.

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Concern has been recently raised for risperidone and olanzapine, possibly associated with cerebrovascular events in placebo-controlled trials conducted in elderly subjects with dementia. We investigated the relationship between exposure to second-generation antipsychotics (SGAs) and occurrence of

Risk of hospitalization for stroke associated with antipsychotic use in the elderly: a self-controlled case series.

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BACKGROUND Antipsychotics are commonly used in the elderly despite a lack of safety data from randomized trials, particularly for the typical antipsychotics. Observational studies have investigated the association between antipsychotics and stroke but results vary, which may be due to lack of

Cerebrovascular accidents in elderly people treated with antipsychotic drugs: a systematic review.

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After 2002, an association between stroke and antipsychotic use was reported in clinical trials and large database studies. This review considers previous quantitative reviews, newly published clinical trials, and recent observational cohort and case-control studies, and focuses on the clinical

Antipsychotic drugs increase risk of stroke.

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Patients taking antipsychotics for dementia are at significantly increased risk of having a stroke, researchers from the London School of Hygiene and Tropical Medicine have said.

Effect of different antipsychotic drugs on short-term mortality in stroke patients.

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The safety, tolerability, and efficacy data for antipsychotic drugs used in the acute phase of stroke are limited. The primary aim of this study was to examine the effectiveness and safety of typical and atypical antipsychotics on acute ischemic stroke mortality.This observational study was

Risk of stroke with typical and atypical anti-psychotics: a retrospective cohort study including unexposed subjects.

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The purpose of the study was to investigate the risk of stroke with typical and atypical anti-psychotics in elderly subjects, weighting for a number of known risk factors, including dementia. Data were retrospectively drawn from the primary care setting from the Health Search Database, which stores

Risk of cerebrovascular accident associated with use of antipsychotics: population-based case-control study.

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OBJECTIVE To explore the association between use of antipsychotics and risk of cerebrovascular accident (CVA) in individuals with dementia aged 65 and older. METHODS Population-based case-control study. METHODS UK-based electronic primary care records in the General Practice Research Database

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