no intervention of health product administration,

no intervention of health product administration, patients characteristics, history, matched with patients for age, gender, tobacco consumption and season of inclusion, free of neurologic or psychiatric disease or psychotropic medications or medications known to impact on serotonin

Cerebral Infarction

patients characteristics, history, clinical signs chronology and usual medical care by the emergency units, cerebral infarction area

Usual care patients in neurology department

Collection samples for biochemical determinations of serotonin pathway and kynurenine pathway parameters determinations

blood and urines sampling

depression scale, impulsivity scale, hostility scale , tobacco consumption questioning

Psychiatric evaluation

Centre Hospitalier de Versailles

TSK (Tryptophan - Serotonin - Kynurenine) Biomarkers Assessment in Stroke

Simultaneous Assessments of Serotonin and Kynurenine Pathways Parameters in Patients Shortly (Less Than 4 Hours and a Half) After the Onset of a Cerebral Infarction

platelet serotonin (nM), plasma serotonin (nM), urine serotonin (nM) , plasma 5-HIAA (nM) , urine 5-HIAA (nM) concentrations using three different HPLC systems and methods.

Blood platelets assessements of serotonin (5-HT) transporters using [3H]paroxetine ligand ( fmol/mg proteins) and 5-HT2A receptors using [3H]MDL-100,907 ligand ( fmol/mg proteins)

platelet serotonin (nM), plasma serotonin (nM), urine serotonin (nM) , plasma 5-HIAA (nM) , urine 5-HIAA (nM) concentrations using three different HPLC systems and methods

The first and regulatory enzyme of the kynurenine pathway is the indoleamine-2,3-dioxygenase (IDO). Plasma tryptophan (µM) and plasma kynurenine (µM) concentrations [Trp] and [Kyn] were quantified with HPLC method. [Trp] / [Kyn] ratio (in AU, Arbitrary Units) was used as index for IDO activity .

For patients: patient characteristics, history, clinical signs chronology and medical care by pre-hospital then hospital neurology intensive care, MRI diagnosis validation, cerebral infarction area.
For controls : patient characteristics, history.

patients characteristics, clinical signs and medical care by hospital neurology intensive care.

Patients characteristics, clinical signs and medical care.
.

Interview with the patient, or a patient closely related, or a physician. Scale for depression scores (simplified depression scale from Whooley 2006), concerning the 2 weeks before stroke

Interview with the patient, or a patient closely related, or a physician. Scale for impulsivity scores ( Barratt Impulsiveness scale), concerning the 2 weeks before stroke

Odile VAROQUAUX

Investigator coordinator

Versailles Hospital

Stroke

Instruction in physical training program.

cerebral infarction/nikotín

TSK (Tryptophan - Serotonin - Kynurenine) Biomarkers Assessment in Stroke

ExStroke Pilot Trial: Physical Exercise After Acute Ischaemic Stroke

Gene-by-Smoking Interactions and Risk of Atherosclerosis - Ancillary to ARIC

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