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chloroquine/hypoxia
Odkaz sa uloží do schránky
Strana 1 od 138 výsledky
[Effect of autophagy inhibitor chloroquine on the proliferation of PASMCs induced by hypoxia].
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OBJECTIVE
To investigate the role of autophagy inhibitor chloroquine (CQ) in the proliferation of pulmonary arterial smooth muscle cells (PASMCs) in hypoxia conditions.
METHODS
The following groups in this study were set up: control group, hypoxia group, 50 micromol/L CQ + hypoxia group, 50
The effect of chloroquine on the TRPC1, TRPC6, and CaSR in the pulmonary artery smooth muscle cells in hypoxia-induced experimental pulmonary artery hypertension
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Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by a constant high pulmonary artery pressure and the remodeling of the vessel. Chloroquine (CLQ) has been observed to inhibit calcium influx. The aim of this study is to investigate the effect of CLQ on transient
Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension.
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OBJECTIVE
Sustained pulmonary vasoconstriction and excessive pulmonary vascular remodelling are two major causes of elevated pulmonary vascular resistance in patients with pulmonary arterial hypertension. The purpose of this study was to investigate whether chloroquine induced relaxation in the
[Effects of diazepam and incidence of hypoxemia during acute chloroquine poisoning].
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The effects of diazepam and the incidence of hypoxaemia on the course of acute chloroquine poisoning were studied prospectively in 21 patients. Were excluded patients who had ingested more than one drug or who had major symptoms on admission (systolic blood pressure less than 80 mmHg; QRS greater
[Hypoxemia in acute benign chloroquine intoxication].
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Effect of acidosis and anoxia on the concentration of quinacrine and chloroquine in blood.
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Hepatic response to lysosomal effects of hypoxia, neutral red and chloroquine.
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Chloroquine exerts anti-metastatic activities under hypoxic conditions in cholangiocarcinoma cells.
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Intra-tumoral hypoxia is an environment that promotes tumor cell migration, angiogenesis and epithelial- mesenchymal transition that accounts for a major mechanism of metastasis. Chloroquine potentially offers a new therapeutic approach with an 'old' drug for effective and safe cancer therapies, as
Chloroquine has tumor-inhibitory and tumor-promoting effects in triple-negative breast cancer.
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Toll-like receptor-9 (TLR9) is an intracellular DNA receptor that is widely expressed in breast and other cancers. We previously demonstrated that low tumor TLR9 expression upon diagnosis is associated with significantly shortened disease-specific survival times in patients with triple-negative
Chloroquine treatment in desquamative interstitial pneumonia.
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An infant presented with failure to thrive, tachypnoea, and hypoxia reversed by oxygen. Lung function showed decreased pulmonary compliance; lung biopsy showed desquamative interstitial pneumonitis. Chloroquine 10 mg/kg/day resulted in improvement and relapse when temporarily stopped. The patient
Chloroquine-mediated cell death in metastatic pancreatic adenocarcinoma through inhibition of autophagy.
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BACKGROUND
Cells in the interior of pancreatic tumors are believed to undergo continual autophagy to maintain homeostasis during unregulated growth in hypoxia caused by impaired vascularity. We hypothesize that treating metastatic cells with chloroquine, an inhibitor of autophagy, in hypoxia will
Coptisine protects cardiomyocyte against hypoxia/reoxygenation-induced damage via inhibition of autophagy.
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Coptisine is a natural occurring isoquinoline alkaloid isolated from the traditional Chinese medicinal herb Rhizoma coptidis. Coptisine has been reported to have protective effects on reperfusion injury in cardiomyocytes, however, the underlying mechanism remains uncertain. Here, we used a
4-[3-(2-Nitro-1-imidazolyl)propylamino]-7-chloroquinoline hydrochloride (NLCQ-1), a novel bioreductive compound as a hypoxia-selective cytotoxin.
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A novel weakly DNA-intercalative bioreductive compound. 4-[3-(2-nitro-1-imidazolyl)-propylamino]-7-chloroquinoline hydrochloride (NLCQ-1). has been synthesized and studied as a hypoxia-selective cytotoxin in vitro. NLCQ-1, which shares a similar structure with the DNA-intercalative antimalarial drug
Montelukast inhibits hypoxia inducible factor-1α translation in prostate cancer cells.
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Through regulating the expression of hundreds of genes, hypoxia-inducible factor -1(HIF-1) plays a critical role in hypoxic adaption of cancer cells and is considered as a target for cancer therapy. Here we show that montelukast, a clinical leukotriene receptor antagonist for the treatment of
Protective effects of acetylcholine on hypoxia-induced endothelial-to-mesenchymal transition in human cardiac microvascular endothelial cells
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Endothelial-to-mesenchymal transition (EndMT) has been reported as a key factor in myocardial fibrosis. Acetylcholine (ACh), a neurotransmitter of the vagus nerve, has been confirmed to exert cardio-protective properties with unclear mechanisms. In this study, the specific markers of cell injury,
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