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Global insight into the distribution of velvet-like B protein in Cochliobolus species and implication in pathogenicity and fungicide resistance.

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The Cochliobolus genus consist of over 55 species among which the 5 most devastating are Cochliobolus carbonum, Cochliobolus heterostrophus, Cochliobolus miyabeanus, Crocus sativus and Cochliobolus lunatus causing damages in sorghum, wheat, rice, maize, cassava and soybean estimated at over 10

[Use of Ancient texts in modern therapeutic research].

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Two main purposes were assigned to this study of medicinal prescription of spices at the time of the Roman Empire: analyze Roman pharmacopoeia of spices in reference to modern criteria and assess a new discipline, close to "ethno-botany" and "ethno-pharmacology", aiming to a new approach of drug

Patents on Therapeutic and Cosmetic Applications of Bioactives of Crocus Sativus L. and their Production through Synthetic Biology Methods: A Review.

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BACKGROUND Saffron (Crocus sativus L.) has a long history of use as a food additive and a traditional medicine for treating a number of disorders. Prominent bioactives of saffron are crocin, crocetin and safranal. OBJECTIVE The aim of this study was to carry out an extensive patent search to collect

Crocin as a novel therapeutic agent against colitis.

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Ulcerative colitis is a chronic inflammatory bowel disease with high incidence and prevalence worldwide. To investigate the therapeutic potency of crocin, as a pharmacologically active component of saffron, in dextran sodium sulfate (DSS)-induced colitis mice model. Experimental colitis was induced

Therapeutic potency of crocin in the treatment of inflammatory diseases: Current status and perspective.

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Crocin is the major component of saffron, which is used in phytomedicine for the treatment of several diseases including diabetes, fatty liver, depression, menstruation disorders, and, of special interest in this review, inflammatory diseases. Promising selective anti-inflammatory properties of this

The Role of the P2X7 Receptor in Ocular Stresses: A Potential Therapeutic Target.

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The P2X7 receptor is expressed in both anterior and posterior segments of the eyeball. In the ocular surface, the P2X7 receptor is activated in case of external aggressions: preservatives and surfactants induce the activation of P2X7 receptors, leading to either apoptosis, inflammation, or cell

Pharmacological properties and therapeutic potential of saffron (Crocus sativus L.) in osteosarcoma.

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In this comprehensive study, we aimed to investigate pharmacological properties and therapeutic significance of saffron in osteosarcoma cancer cells.Plant materials were obtained from Safranbolu district of Karabuk, Turkey. For the determination of

Therapeutic effects of saffron (Crocus sativus L.) in digestive disorders: a review.

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Saffron, the dried red-orange stigmas of Crocus sativus L, has been known as a flavoring agent, food coloring and traditional herbal medicine. Pharmacological effects of saffron are mainly attributed to crocin, crocetin, picrocrocin and safranal. These components especially crocin, have significant

Therapeutic use of colchicine and its derivatives: a patent review.

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BACKGROUND Colchicine, the major alkaloid extracted from the meadow saffron (Colchicum autumnale) is one of the most prominent natural products belonging to the class of organic compounds known as tropones. Colchicine's medicinal properties have been long-known, but it has been attracting renewed

Therapeutic effects of Crocin in autoimmune diseases: A review.

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The immune system when acts against selfmolecules results in an imbalance in immunologic tolerance leading to the development of several autoimmune diseases (ADs) such as rheumatoid arthritis, asthma, ulcerative colitis, type 1 diabetes, and multiple sclerosis. Improved recognition of the mechanisms

Saffron: The Golden Spice with Therapeutic Properties on Digestive Diseases.

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Saffron is a natural compound that has been used for centuries in many parts of the world as a food colorant and additive. It was shown to have the ability to mitigate various disorders through its known anti-inflammatory and anti-oxidant properties. Several studies have shown the effectiveness of

The Prophylactic and Therapeutic Effects of Saffron Extract and Crocin on Ethanol Withdrawal Syndrome in Mice.

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Objectives

Ethanol withdrawal following its chronic use is a serious outcome and challenging to treatment. The chronic use of ethanol induces a progressive neuroplasticity in different reigns of brain. In this study we evaluated the effects of aqueous extract of Crocus

Functional genomics of apocarotenoids in saffron: insights from chemistry, molecular biology and therapeutic applications.
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Saffron is considered to be the costliest spice of the world. It has been regarded as highly valued medicinal plant in Ayurveda to treat various ailments. Over the past few years, considerable interest has developed in saffron because of its anticancer, antimutagenic, antioxidant and

Safranal epoxide - A potential source for diverse therapeutic applications.
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Safranal is an organic compound isolated from saffron oil. Photo epoxidation and thermal reactions of safranal can be a significant tool for the design of drugs to act as anticancer agents and potent chemoprevention. Safranal was subjected to oxidation reactions either thermally using

Possible Role of Common Spices as a Preventive and Therapeutic Agent for Alzheimer's Disease.
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For centuries, spices have been consumed as food additives or medicinal agents. However, there is increasing evidence indicating the plant-based foods in regular diet may lower the risk of neurodegenerative diseases including Alzheimer disease. Spices, as one of the most commonly used plant-based

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