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A combination of complexation and self-nanoemulsifying drug delivery system for enhancing oral bioavailability and anticancer efficacy of curcumin.

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OBJECTIVE Curcumin, the golden spice from Indian saffron, has shown chemoprotective action against many types of cancer including breast cancer. However, poor oral bioavailability is the major hurdle in its clinical application. In the recent years, self-nanoemulsifying drug delivery system (SNEDDS)

Antitumor activity of PEGylated nanoliposomes containing crocin in mice bearing C26 colon carcinoma.

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Crocin is a pharmacologically active component of Crocus sativus. It is an unusual water-soluble carotenoid responsible for the red color of saffron. In various studies, the anticancer effect of saffron and its constituents has been established. Polyethylene glycolated nanoliposomes with a size

Saffron and natural carotenoids: Biochemical activities and anti-tumor effects.

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Saffron, a spice derived from the flower of Crocus sativus, is rich in carotenoids. Two main natural carotenoids of saffron, crocin and crocetin, are responsible for its color. Preclinical studies have shown that dietary intake of some carotenoids have potent anti-tumor effects both in vitro and in

Anti-Cancer Effects of Traditional Medicinal Herbs on Oral Squamous Cell Carcinoma.

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Oral squamous cell carcinoma (OSCC) is among the most frequent oral cancers in individuals under 40. Documents have endorsed that a diet enriched with fruit and vegetables can banish the risk of developing major cancers. This study aimed to evaluate the effects of different

Natural compounds for pediatric cancer treatment.

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There is a tremendous need in clinics to impair cancer progression through noninvasive therapeutic approaches. The use of natural compounds to achieve this is of importance to improve the quality of life of young patients during their treatments. This review will address the "status of the art"

Antitumour activity of saffron (Crocus sativus).

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Antitumor activity of saffron (Crocus sativus) extract a commonly used spice in India was studied against intraperitoneally transplanted sarcoma-180 (S-180), Ehrlich ascites Carcinoma (EAC) and Dalton's lymphoma ascites (DLA) tumours in mice. Oral administration of 200 mg/kg body weight of the

[Antitumor activity of natural substances: lectins and saffron].

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A major problem in the use of chemopreventing agents in cancer treatment is the potential toxicity of these drugs to normal cells. One approach to solve this problem is to employ the inhibitors of tumorigenesis which have a natural origin. Within the past few years, natural extracts or purified

Effect of saffron on thymocyte proliferation, intracellular glutathione levels and its antitumor activity.

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Liposome encapsulation of saffron effectively enhanced its antitumor activity towards Sarcoma-180 (S-180) and Ehrlich ascites carcinoma solid tumors in mice. Significant inhibition (P < 0.001) in the growth of these tumors was observed as compared with vehicle (control) mice. In the presence of

Phytochemical properties of Iranian organic saffron stigma: antioxidant, anticancer and apoptotic approaches.

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Agronomic and environmental factors affect quality and quantity of constituents in Saffron. In this study, we compared chemical and antioxidant compounds of organic (OS) and inorganic (IOS) stigma of saffron and evaluated their anti-proliferative and apoptosis effects on cancer cells. Total

Anticancer Effect and Molecular Targets of Saffron Carotenoids.

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Saffron carotenoids, crocin and crocetin, have shown anticancer activity in various animal models of cancer and against different cancerous cell lines. The radical scavenging property and activation of antioxidant defense system are two well-known characteristics of these compounds. However, the

Tumor-Suppressing Properties of Crocus sativus L.: Nature as an Anti-Cancer Agent.

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Cancer is a growing problem because it is a chronic disease that affects, not only patient health, but also its daily living. Concurrent cancer therapies have ameliorated cancer prevalence, but the severity and frequency of toxicity and side effects during therapy have led the scientific community

Comparative reverse screening approach to identify potential anti-neoplastic targets of saffron functional components and binding mode.

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BACKGROUND In the last two decades, pioneering research on anti-tumour activity of saffron has shed light on the role of crocetin, picrocrocin and safranal, as broad spectrum anti-neoplastic agents. However, the exact mechanisms have yet to be elucidated. Identification and characterization of the

Antitumor effects of crocin on human breast cancer cells.

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Crocin is a chemical extracted from saffron and it is the most important kind of pigment of saffron. It has been proposed as a promising candidate for cancer prevention. In this study, we investigate the growth inhibition and the apoptosis of MCF-7 cells induced by Crocin, and explore the underlying

Indian food ingredients and cancer prevention - an experimental evaluation of anticarcinogenic effects of garlic in rat colon.

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The major food items of Indian cuisine include rice, wheat, diary products, and abundant fruits and vegetables. Beside these, there are several kinds of herbs and spices as important ingredients, containing many phytochemicals with medicinal properties, adding taste to Indian cuisine. An impressive

Anticancer effects of crocetin in human esophageal squamous cell carcinoma KYSE-150 cells.

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Crocetin is the main pharmacologically-active component of saffron and has been considered as a promising candidate for cancer chemoprevention. The purpose of the present study was to investigate the anticancer effects of crocetin and the possible mechanisms of these properties in the esophageal

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