cyclooxygenase/horúčka

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Cyclooxygenase-2 selective inhibitors, compositions and methods of use

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FIELD OF THE INVENTION The invention describes novel nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compound that

Cyclooxygenase-2 selective inhibitors, compositions and methods of use

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FIELD OF THE INVENTION The invention describes novel nitrosated and/or nitrosylated cyclooxygenase 2(COX-2) selective inhibitors and novel compositions comprising at least one nitrosated and/or nitrosylated cyclooxygenase 2(COX-2) selective inhibitor, and, optionally, at least one compound that

Cyclooxygenase 2 selective inhibitors, compositions and methods of use

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Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use

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FIELD OF THE INVENTION The present invention describes novel nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) inhibitors and novel compositions comprising at least one nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) inhibitor, and, optionally, at least one compound that donates,

Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use

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Oxime and/or hydrozone containing nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use

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RELATED APPLICATIONS This application claims priority under 35 USC .sctn. 119 to U.S. application Ser. No. 60/392,044, filed Jun. 28, 2002, which is incorporated herein by reference. FIELD OF THE INVENTION The invention describes novel nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2)

Multibinding inhibitors of cyclooxygenase-2

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BACKGROUND OF THE INVENTION 1. Field of the Invention This invention relates to novel multibinding compounds (agents) that inhibit the enzyme cyclooxygenase-2 (COX-2) and to pharmaceutical compositions comprising such compounds. Accordingly, the multibinding compounds and pharmaceutical compositions

5-methylthio-3-hydroxybenzo [b]thiophene-2-carboxamide derivatives as cyclooxygenase and lipoxygenase inhibitors

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BACKGROUND OF THE INVENTION This invention relates to benzothiophenes, particularly, 3-hydroxybenzo[b]thiophene-2-carboxamides, which are found to be effective cyclooxygenase and 5-lipoxygenase inhibitors and are therefore useful in the treatment of inflammation and other prostaglandin and

N-substituted fused-heterocyclic carboxamide derivatives as dual cyclooxygenase and lipoxygenase inhibitors

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BACKGROUND OF THE INVENTION This invention relates to fused heterocyclic carboxamides, for example, N-(2,2-diphenylethenyl)-3-hydroxythieno[3,2-b]thiophene-2-carboxamide. These novel compounds are found to be effective cyclooxygenase and 5-lipoxygenase inhibitors and are therefore useful in the

Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase

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BACKGROUND OF THE INVENTION This invention relates to compounds and pharmaceutical compositions for the treatment of cyclooxygenase mediated diseases and methods of treating thereof. Non-steroidal, antiinflammatory drugs exert most of their antiinflammatory, analgesic and antipyretic activity and

N-alkenyl-2-hydroxybenzo(b)thiophene-3-carboxamide derivatives as dual cyclooxygenase and lipoxygenase inhibitors

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BACKGROUND OF THE INVENTION This invention relates to benzothiophenes, particularly 2-hydroxybenzothiophenes having the unusual 3-enamido side chains, for example, ##STR1## These novel compounds can be effective cyclooxygenase and 5-lipoxygenase inhibitors and therefore can be useful in the

N-alkenyl-3-hydroxybenzo[b]thiophene-2-carboxamide derivatives as dual cyclooxygenase and lipoxygenase inhibitors

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BACKGROUND OF THE INVENTION This invention relates to benzothiophenes, particularly 3-hydroxybenzothiophenes having the unusual 2-enamido side chains, for example, ##STR1## These novel benzothiophenes are found to be effective cyclooxygenase and 5-lipoxygenase inhibitors and are therefore useful in

Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use

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Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use

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FIELD OF THE INVENTION The invention describes novel substituted aryl compounds that are cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compound that donates, transfers or

N-alkenyl-3-hydroxybenzo[b]thiophene-2-carboxamide derivatives as dual cyclooxygenase and lipoxygenase inhibitors

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BACKGROUND OF THE INVENTION This invention relates to benzothiophenes, particularly 3-hydroxybenzothiophenes having the unusual 2-enamido side chains, such as those of Formula I: ##STR2## Compounds of formula I have been found to be effective inhibitors of both cyclooxygenase and lipoxygenase and

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