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cyclooxygenase/nekróza
Odkaz sa uloží do schránky
9 výsledky
Method for inhibiting cyclooxygenase-2 and tumor necrosis factor alpha
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to methods for inhibiting cyclooxygenase-2 (COX-2) and tumor necrosis factor alpha (TNF.alpha.) activities and treating disorders and diseases associated with elevated COX-2 and TNF.alpha. activities.
2. Description
Use of sesquiterpene lactones for treatment of severe inflammatory disorders
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This invention pertains to sesquiterpene lactones and sesquiterpene lactone-containing plant extracts and preparations for pharmaceutical uses, particularly the use of sesquiterpene lactones for the treatment of severe inflammatory disorders, for example, sepsis, septic shock, or septicemia.
A large
Methods of treating skin with aromatic skin-active ingredients
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BACKGROUND OF THE INVENTION
A. Field of the Invention
The present invention relates generally to methods of treating skin. In particular, the present invention concerns topical skin care compositions that include ingredients found to have beneficial effect on skin.
B. Description of Related Art
In
Regulation of x-ray mediated gene expression
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates generally to the fields of radiation biology and cell biology. More particularly, it concerns the attenuation of the effect of ionizing radiation induced activation of cytokines, such as tumor necrosis factor, by
Tricyclic compounds and uses thereof
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FIELD OF THE INVENTION
The present invention relates to tricyclic compounds, namely, substituted isoquinolines, isochromanones and isothiochromanones that inhibit the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and/or interleukin-6 (IL-6) and/or the enzyme cyclooxygenase-2
Substituted pyrazole compounds
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TECHNICAL FIELD
This invention relates to novel aminopyrazole derivatives or salts thereof. More particularly, it relates to substituted pyrazole compounds represented by the following formula, or salts thereof.
##STR00002## wherein:
R.sup.1 represents a group of any one of the following formulae i)
Substituted pyrazole compounds
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TECHNICAL FIELD
This invention relates to novel aminopyrazole derivatives or salts thereof. More particularly, it relates to substituted pyrazole compounds represented by the following formula, or salts thereof. ##STR2##
wherein: R.sup.1 represents a group of any one of the following formulae i) to
Method of use of radicicol for treatment of immunopathological disorders
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates generally to the compound, radicicol, and specifically to the use of radicicol for the treatment of inflammation and endotoxemia-associated disorders.
2. Description of Related Art
Inflammation is a protective reaction
Anti-inflammatory composition containing macrolactin A and a derivative thereof as active ingredients
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CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a 371 of PCT/KR2010/003239, filed on May 24, 2010, which claims the benefit of Korean Patent Application Nos. 10-2009-0044900, filed on May 22, 2009, and 10-2010-0029016, filed on Mar. 31, 2010, the contents of each of which are
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