Clinical data including medical history, plain KUB x-ray and renal ultrasound, routine blood work and 24-hour urine collections for all subjects will be collected as part of normal clinical care at routine clinical visit every 4 months.
Subjects in this study arm will be taking one supplement tablet containing 1200 mg of alpha lipoic acid orally once daily for three years.
At the end of the three years of study drug treatment, all subjects will undergo a low dose non-contrast CT scan to look for a silent change in stone size.

Clinical data including medical history, plain KUB x-ray and renal ultrasound, routine blood work and 24-hour urine collections for all subjects will be collected as part of normal clinical care at routine clinical visit every 4 months.
Subjects in this study arm will be taking one placebo tablet containing 10 mg of sucrose orally once daily for three years.
At the end of the three years of study drug treatment, all subjects will undergo a low dose non-contrast CT scan to look for a silent change in stone size.

Cystinuria

Already mentioned in arm/group descriptions.

Alpha lipoic acid

Placebo

University of California, San Francisco

Lipoic Acid Supplement for Cystine Stone

The Effect of Lipoic Acid Natural Supplement on Cystine Stone Formation

The primary efficacy endpoint will be assessed in two ways:
symptomatic stone recurrences, defined as renal colic, stone passage, or surgical removal of a stone;
silent stone recurrences, classified as stone growth or new stones, diagnosed on the basis of renal ultrasound, plain KUB x-ray, or if clinically indicated, computed tomography.

The secondary endpoints will be quantitative urinary cystine level determined by 24-hour urine collection.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Obesity

Kidney Stones

recommendation of daily ingestion of 2500 ml of water and low-calorie diet of 16 Kcal/kg bw/day

Hypocaloric diet

University of Sao Paulo General Hospital

Influence of Hypocaloric Diet on Urinary Lithogenic Factors of Obese Patients With Kidney Stones

serum and 24h urine test as before the diet.

Condensed data will be available for consultation

Fundação de Amparo à Pesquisa do Estado de São Paulo

Cystagon-EC

Sex: Female, Male

Region of Enrollment

Number of Improved Subjects

Normalization or >50% of Serum ALT Levels From Baseline

Overall Study

Dr. Joel Lavine

Fatty Liver

Drug is in enteric-coated capsule form. The dosage will begin at 1g/m-squared body surface area with a maximum dose of 1000mg twice daily. Treatment period is 3-6 months.

cystine/obezita

Lipoic Acid Supplement for Cystine Stone

Influence of Hypocaloric Diet on Urinary Lithogenic Factors of Obese Patients With Kidney Stones

A Preliminary Study to Evaluate Cysteamine Therapy in Human Subjects With Non-Alcoholic Steatohepatitis (NASH)

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