endometriosis/protease

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Cathepsin Protease Inhibition Reduces Endometriosis Lesion Establishment.

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Endometriosis is a gynecologic disease characterized by the ectopic presence of endometrial tissue on organs within the peritoneal cavity, causing debilitating abdominal pain and infertility. Current treatments alleviate moderate pain symptoms associated with the disorder but exhibit limited ability

Expression of secretory leukocyte protease inhibitor in women with endometriosis.

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OBJECTIVE To explore endometriosis-related molecules in patients with use of differential display analysis. METHODS Prospective study. METHODS Nagoya City University Medical School, Nagoya, Japan. METHODS Women with endometriosis (n = 27) and without endometriosis (n = 21). METHODS Surgery was

Secretory leukocyte protease inhibitor in ovarian endometriomas following GnRH agonist therapy.

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OBJECTIVE To determine whether expression of secretory leukocyte protease inhibitor is affected in tissue and peritoneal fluid of women with ovarian endometriomas treated with GnRH analogues. METHODS In 32 women with endometriomas (17 untreated and 15 treated with GnRH analogue) and 21 with ovarian

Association of protease activity against IGFBP-3 with peritoneal fluid mitogens: possible implications for the ectopic growth of endometrial cells in women with endometriosis.

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BACKGROUND Recent data indicate the implication of an IGF/IGFBP/protease system in the development of ectopic implants of endometrium (endometriosis) in the pelvic cavity. METHODS We characterized mitogens and protease(s) against IGFBP-3 in the peritoneal fluid of women with or without endometriosis

Increased concentrations of secretory leukocyte protease inhibitor in peritoneal fluid of women with endometriosis.

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Secretory leukocyte protease inhibitor (SLPI) is a potent inhibitor of human leukocyte elastase. We investigated whether SLPI was present in the peritoneal fluid of women with endometriosis and to clarify the role of SLPI in the pathogenesis of endometriosis. Western blot analyses revealed that SLPI

Protein, progesterone, and protease inhibitors in uterine and peritoneal fluids of women with endometriosis.

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This study was undertaken to determine whether women with endometriosis have altered protein, progesterone (P), and protease inhibitor concentrations in their uterine fluid and peritoneal fluid (PF) compared with controls at different phases of the menstrual cycle. Uterine flushings (UFs), PF, and

Protease-activated receptor-stimulated interleukin-6 expression in endometriosis-like lesions in an experimental mouse model of endometriosis.

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The present study was undertaken to investigate the function of protease-activated receptor (PAR) in endometriotic lesions using a mouse model of endometriosis. Unilateral ovariectomy (uOVX) was performed on female nude mice followed by intraperitoneal transplantation of a suspension mixture of

Possible involvement of thrombin/protease-activated receptor 1 system in the pathogenesis of endometriosis.

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Endometriosis is known to be associated with local inflammatory reactions. Given the emerging concept of thrombin and its specific receptor, protease-activated receptor 1 (PAR1), as important players in inflammation and cell proliferation, we investigated whether thrombin and PAR1 might be involved

ENMD-1068, a protease-activated receptor 2 antagonist, inhibits the development of endometriosis in a mouse model.

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OBJECTIVE Protease-activated receptor 2 plays an important role in the pathogenesis of endometriosis. We studied the effect of ENMD-1068, a protease-activated receptor 2 antagonist, on the development of endometriosis in a noninvasive fluorescent mouse model. METHODS A red fluorescent

Insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and IGFBP-3 protease activity in the peritoneal fluid of patients with and without endometriosis.

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OBJECTIVE To compare levels of insulin-like growth factor (IGF) components in the peritoneal fluid of patients with and without endometriosis. METHODS Patients with endometriosis were compared with control patients. METHODS Seoul National University Hospital, Korea. METHODS Forty-three patients with

Elevated peritoneal fluid TNF-α incites ovarian early growth response factor 1 expression and downstream protease mediators: a correlation with ovulatory dysfunction in endometriosis.

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Endometriosis-associated infertility manifests itself via multiple, poorly understood mechanisms. Our goal was to characterize signaling pathways, between peritoneal endometriotic lesions and the ovary, leading to failed ovulation. Genome-wide microarray analysis comparing ovarian tissue from an in

Multiplexed protease activity assay for low-volume clinical samples using droplet-based microfluidics and its application to endometriosis.

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As principal degrading enzymes of the extracellular matrix, metalloproteinases (MPs) contribute to various pathologies and represent a family of promising drug targets and biomarker candidates. However, multiple proteases and endogenous inhibitors interact to govern MP activity, often leading to

The intricate role of mast cell proteases and the annexin A1-FPR1 system in abdominal wall endometriosis.

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Endometriosis is a continuous and progressive disease with a poorly understood aetiology, pathophysiology and natural history. This study evaluated the histological differences between eutopic and ectopic endometria (abdominal wall endometriosis) and the expression of mast cell proteases (tryptase

Activin-A is induced by interleukin-1β and tumor necrosis factor-α and enhances the mRNA expression of interleukin-6 and protease-activated receptor-2 and proliferation of stromal cells from endometrioma.

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OBJECTIVE To examine the regulation and the function of activin-A in stromal cells derived from endometrioma. METHODS Molecular studies. METHODS University research laboratory. METHODS Endometrioma stromal cells (EoSC) were obtained from 28 patients with ovarian endometrioma undergoing

The role of tissue factor and protease-activated receptor 2 in endometriosis.

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OBJECTIVE Little is known about the roles of TF and PAR-2 in endometriosis. This article investigated the expression of TF and PAR-2 in ectopic and eutopic endometrium with endometriosis and their relationship with the menstrual cycle. METHODS Ectopic and eutopic endometrium tissues from 42 women

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