Protein 1.5 gm/kg/day, energy (kcal) 30-40/day, B complex vitamins daily. Pasteurized Bovine colostrum as a freeze dried powder (20 gm thrice a day) for 4 weeks.
+ Antibiotics + Diuretics +Terlipressin for HRS + acid suppression for prophylaxis against gastrointestinal hemorrhage + EVL for variceal bleed +drugs for HE if indicated

Protein 1.5 gm/kg/day, energy (kcal) 30-40/day, B complex vitamins daily. Placebo (Pasteurised Milk Powder) 20 gms thrice a day for 4 weeks
+ Antibiotics + Diuretics + drugs for HE + Terlipressin for HRS + acid suppression for prophylaxis against gastrointestinal hemorrhage + EVL for variceal bleed + if indicated.

Alcoholic Hepatitis

Bovine Colostrum

Placebo

Department of Gastroenterology, D.M.C. and Hospital

Comparison of Bovine Colostrum Versus Placebo in Treatment of Severe Alcoholic Hepatitis: A Randomized Double Blind Controlled Trial

Change in mDF levels will be measured at baseline and after 30 days of treatment

Change in Endotoxin levels will be measured at baseline and after 4 weeks of treatment

Change in Cytokines levels will be measured at baseline and after 30 days of treatment

Number of episodes of sepsis (bacteremia, Pneumonia, SBP, Cellulitis, UTI)

esophageal and gastric varices/hnačka

Comparison of Bovine Colostrum Versus Placebo in Treatment of Severe Alcoholic Hepatitis: A Randomized Double Blind Controlled Trial

Probiotics for the Prevention of Major Complications of Cirrhosis

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