euphorbia serrata/protizápalový

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Studies on phytochemical, antioxidant, anti-inflammatory and analgesic activities of Euphorbia dracunculoides.

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BACKGROUND Plants provide an alternative source to manage various human disorders due to diverse metabolites. Euphorbia dracunculoides of family Euphorbiaceae is used by local practitioners in rheumatism, epilepsy, edema, snake bite, warts and also possesses diuretic and purgative effects. The

Topical anti-inflammatory effect of tirucallol, a triterpene isolated from Euphorbia lactea latex.

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Latex from Euphorbia lactea (Euphorbiaceae), a native Dominican medicinal plant, is claimed to be useful in the treatment of inflammation. Topical application of tirucallol, a tetracyclic triterpene isolated from Euphorbia lacteal latex, suppressed ear edema in the mouse model in a dose-dependent

The role of PKC/ERK1/2 signaling in the anti-inflammatory effect of tetracyclic triterpene euphol on TPA-induced skin inflammation in mice.

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Inflammation underlies the development and progression of a number of skin disorders including psoriasis, atopic dermatitis and cancer. Therefore, novel antiinflammatory agents are of great clinical interest for prevention and treatment of these conditions. Herein, we demonstrated the underlying

Anti-inflammatory Ingenane Diterpenoids from the Roots of Euphorbia kansui.

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Bioassay-guided fractionation of the ethanolic extract of the roots of Euphorbia kansui led to the isolation of two new ingenane diterpenoids, euphorkans A (1: ) and B (2: ), together with 16 known analogues (3: - 18: ). Their structures were determined by combined spectral and chemical methods.

Discovery and biological evaluation of the novel naturally occurring diterpene pepluanone as antiinflammatory agent.

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From the whole plant of Euphorbia peplus L., a new diterpene based on a rare pepluane skeleton, named pepluanone (1), was isolated together with a known pepluane diterpene (2). The stereostructure of pepluanone was determined on the basis of an extensive NMR study, MS data, and chemical reaction.

Antinociceptive and Anti-Inflammatory Activities of the Ethanolic Extract from Synadenium umbellatum Pax. (Euphorbiaceae) Leaves and Its Fractions.

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Synadenium umbellatum Pax., popularly known in Brazil as "cola-nota," "avelós," "cancerola," and "milagrosa", is a plant species used in folk medicine for the treatment of inflammation, pain, and several diseases. This study aimed to investigate the antinociceptive and anti-inflammatory activities

Anti-inflammatory and antioxidant activity of a medicinal tincture from Pedilanthus tithymaloides.

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Pedilanthus tithymaloides (L.) Poit. (Euphorbiaceae) is a low tropical American shrub with a reported wide range of healing properties such as emetic, anti-inflammatory, antibiotic, antiseptic, antihemorrhagic, antiviral, antitumoral, and abortive. In the present study, a tincture from P.

Anti-inflammatory effect of Euphorbia supina extract in dextran sulfate sodium-induced colitis mice.

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The aim of this study is to examine the anti-inflammatory effect of Euphorbia supina (ES) ethanol extract in dextran sulfate sodium (DSS)-induced experimental colitis model. ES was per orally administered at different doses of 4 or 20 mg/kg body weight with 5% DSS in drinking water for 7 days.

Anti-inflammatory studies on Euphorbia prostrata.

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Anti-inflammatory studies were conducted in rats on an ethanol extract of whole plant Euphorbia prostrata and its partitioned fractions. The ethyl acetate fraction in an oral dose of 200 mg/kg, inhibited 76% of acute carrageenan-induced paw edema. A fraction, labelled as KSE-23, isolated from the

Topical antiinflammatory effects of Euphorbia prostrata on carrageenan-induced footpad oedema in mice.

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The ethyl acetate extract and a fraction, KSE-23, isolated chromatographically from the ethyl acetate extract of Euphorbia prostrata, showed significant antiinflammatory activity when topically applied in a murine model of carrageenan footpad oedema. KSE-23 was found to be more potent than

Cycloarta-23-ene-3beta,25-diol a pentacyclic steroid from Euphorbia spinidens, as COX inhibitor with molecular docking, and in vivo study of its analgesic and anti-inflammatory activities in male Swiss mice and Wistar rats

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Background and aims: Euphorbia is a large genus of flowering plants. In Iran, some plants of this family have been used in the treatment of inflammatory disorders and also to relieve back pain. Euphorbia spinidens is a rich source of

Chemical Composition and Antioxidant, Analgesic, and Anti-Inflammatory Effects of Methanolic Extract of Euphorbia retusa in Mice.

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Plants provide an alternative source to manage different human disorders due to various metabolites. The aim of this study is to investigate the phytochemical constituents of the methanolic extracts of Euphorbia retusa and to evaluate their antioxidant, anti-inflammatory, and analgesic activities.

NO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorum.

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Two new ent-atisane-type diterpenoids (1 and 2), three new lathyrane-type diterpenoids (3-5), and seven known analogues (6-12) were isolated from Euphorbia antiquorum. The structures of these diterpenoids were established by analysis of their NMR, MS, and electronic circular dichroism data. The

Synthesis of new lathyrane diterpenoid derivatives from Euphorbia lathyris and evaluation of their anti-inflammatory activities.

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Euphorbia factor L3, a lathyrane diterpenoid extracted from Euphorbia lathyris, was found to display good anti-inflammatory activity with very low cytotoxicity. To find more potent anti-inflammatory drugs, two series of Euphorbia factor L3 derivatives with fatty and aromatic acids were designed and

Macrocyclic Diterpenoids from Euphorbia helioscopia and Their Potential Anti-inflammatory Activity.

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Guided by ¹H NMR spectroscopic experiments using the aromatic protons as probes, 11 macrocyclic diterpenes (1-11) were isolated from the aerial parts of Euphorbia helioscopia. Their full three-dimensional structures, including absolute configurations, were established

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