Venous Insufficiency of Leg

Venous Reflux

Varicose Veins

Lower Extremity Edema Chronic

Vasculera is a specially formulated prescription medical food product. This study compares Vasculera to placebo at reducing post procedural pain, bruising and edema for patients requiring an intervention for lower extremity venous disease.
Patient will be randomized to receive Active Vasculera or Vasculera Placebo. The study product will be taken for two weeks prior to the patient's planned procedure and continued for four weeks after their procedure. If multiple procedures are required the patient will be instructed to use the product throughout treatment.

Vasculera

Placebo

Spectrum Health Hospitals

Efficacy of Vasculera in Prevention on Post-op Pain and Edema Following Lower Extremity Venous Treatment in the Outpatient Setting

Efficacy of Vasculera in Prevention on Post-op Pain and Edema Following Lower Extremity Venous Treatment in the Outpatient Setting.

Deep Vein Thrombosis (DVT) Pulmonary Embolism (PE) and Infection.

Primus Pharmaceuticals

This group received Ginko Biloba, two tablets per day

This group received placebo two tablets per day .

Intrauterine Growth Restriction (IUGR)

Ginkgo Biloba Extract

Role of Ginkgo Biloba Extract in IUGR

Effects of Oral Ginkgo Biloba Extract on Pregnancy Complicated by Asymmetrically Intrauterine Growth Restriction: a Double-blinded Randomized Placebo-controlled Trial

mohamad sayed abdellah

Assiut University

Study patients diagnosed with acute pouchitis after bowel surgery for ulcerative colitis will perform manuka honey enemas twice a day for 30 days.

Pouchitis

Study patients diagnosed with acute pouchitis will perform manuka honey enemas twice a day for 30 days.

Manuka honey enema

Saint Paul's Hospital

To Determine the Effect of Honey Enema in the Treatment of Patients With Acute Pouchitis

To Determine the Effect of Honey Enema in the Treatment of Patients With Acute Pouchitis (Pilot Study)

PDAI score is a criterion for defining pouchitis. A PDAI score will be calculated from a proctoscopy assessment before treatment. Within two weeks after the treatment, another proctoscopy will be performed to determine the post-treatment PDAI score to see if there is a decrease in PDAI score for the study patients.

includes stool frequency (no different, 1-2 stools/day > postoperative usual, 3 or more stools/day > postoperative usual), rectal bleeding (none or rare or present daily), fecal urgency or abdominal cramps (none, occasional or usual), presence of fever (temperature >37.8° C), abdominal pain (no, occasional or usual) and readmission to hospital for any reason.

Dr. Carl J Brown

Head, Division of General Surgery, clinical assistant professor of surgery at University of British Columbia

Canadian Association of General Surgeons

Detralex 500 mg twice daily for three month prior to surgery

Not taking Detralex for three months prior to surgery

Chronic Venous Insufficiency

Detralex

University Hospital Dubrava

Study of Antiinflammatory Effects of Detralex (Daflon)

Study of Antiinflammatory Effects of Detralex (Daflon) in Patients With Chronic Venous Disease

The following markers of inflammation will be analyzed:
Blood (biochemical analysis): soluble ICAM-1, soluble VCAM-1, E-selectin, L selectin PAI-1, TIMP-1, Angiopoietin-1, Angiopoietin-2 and Tie-2.
Vein wall ([immuno]histological and biochemical analysis) : CD 45 (leukocytes), S100 (C-fibers), MMP3, MMP9, SMC (smooth muscle cells). Presence (or not) of microthrombi in the vein lumen

Subjective perception of pain, leg heaviness, cramping and itching will be assessed using visual analogue scale (VAS) graded from 0 to 10. Leg edema will be assessed by measuring the leg circumference. Data will be recorded as follow:
three months before the surgery
one day before the surgery
one week after the surgery
one month after bthe surgery
three months after the surgery

flavonoid/opuch

Efficacy of Vasculera in Prevention on Post-op Pain and Edema Following Lower Extremity Venous Treatment in the Outpatient Setting

Role of Ginkgo Biloba Extract in IUGR

To Determine the Effect of Honey Enema in the Treatment of Patients With Acute Pouchitis

Study of Antiinflammatory Effects of Detralex (Daflon)

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