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Strana 1 od 35 výsledky
Gossypol promotes degeneration of ovarian follicles in rats.
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The present study aimed to determine if gossypol interferes with ovarian follicles in rats. Twenty-four female Wistar rats were assigned to two equal groups: one control group and the other dosed with gossypol (25 mg/kg/day, subcutaneously) for 15 days. Ovarian follicles were histologically
Epididymis-specific pathologic disorders in rats exposed to gossypol from weaning through puberty.
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Previous work in our laboratory revealed that the pubertal period of reproductive development in the male rat was particularly vulnerable to gossypol exposure, with a higher frequency of round structures in the lumen of the cauda epididymidis in the treated rats. Herein, we utilized hemicastration
The effects of gossypol on spermatogenesis and development of the eyefluke, Philophthalmus gralli, and its chicken host.
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To determine the effects of gossypol, a male antifertility drug, on the eyefluke, P. gralli, this chemical was administered orally to chickens in long-term and short-term regimens. Gossypol acetic acid (GAA), fed to juvenile chickens from 1 to 35 days, caused a decreased weight gain when compared to
Effect of gossypol on the fertility of male rats.
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Thirty male rats were grouped into 5 groups of 6 animals each. Animals in groups II-V were given gossypol at a dose of 5 mg/kg, 10 mg/kg, 20 mg/kg and 40 mg/kg body weight per day for 45 days respectively. Animals of group I served as control. A significant decrease in body weight after
Antifertility effect of gossypol in male Japanese quail.
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Conventionally housed 130-160 g adult male Japanese quail were given gossypol acetic acid (gossypol) im at 25 mg/kg in 0.5 ml of 10% EtOH for 12 and 24 days (Groups 1 and 2), respectively. One day after treatment was terminated they were allowed to mate with laying females individually for 20 days.
The effect of gossypol acetic acid on the different stages of the spermatogenic cycle in the rat.
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The reversibility of the effect of gossypol on testicular histology and fertility was studied in rats. Adult males of proven fertility were treated orally with gossypol acetic acid (15 mg/kg) for 9 or 16 weeks (groups 1 and 2, respectively). Another groups of animals (group 3) was given gossypol (15
Spermatotoxicity, biochemical changes and histological alteration induced by gossypol in testicular and hepatic tissues of male rats.
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Gossypol acetic acid (GAA) displays anti-fertility and antioxidant behavior. The efficacies of different doses of gossypol acetic acid were investigated in male albino rats. Rats were allocated into four groups: control group and three GAA-treated groups (2-4), that were injected with GAA (5, 10,
Cottonseed meal (gossypol) toxicosis in a swine herd.
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Cottonseed meal (CSM) that contained a high concentration of free gossypol was inadvertently used as a protein supplement, without appropriate iron supplementation, for a swine herd in Illinois. Fifty percent of 300 grower and finishing swine died, and an additional 20% became ill during a 4- to
Ethanol intake may modify gossypol toxicosis in the rat.
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Some aspects of the toxicity of gossypol were investigated in ethanol-fed, gossypol-treated Sprague-Dawley rats, with and without protein malnutrition. Serum creatine phosphokinase activity was depressed in all gossypol-treated rats and gossypol caused greater decreases than ethanol in those animals
Influence of gossypol on the secretory function of cultured rat sertoli cells.
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Cottonseed gossypol is a potent male contraceptive in several mammalian species including man. Sertoli cells play a crucial role in spermatogenesis. Therefore, the antifertility competence of gossypol may reflect a change in Sertoli cell function. Rat primary cultures were used to examine the effect
Probing into the mechanism of action, metabolism and toxicity of gossypol by studying its (+)- and (-)-stereoisomers.
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The chemistry of gossypol is very relevant to its unique actions. The two aldehyde groups can easily bind to proteins via aldehyde-amino group linkage. Gossypolone, the in vivo oxidation product of gossypol, may form a redox system with its corresponding hemiquinone, leading to free radical
Gossypol toxicosis in a dog consequent to ingestion of cottonseed bedding.
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Six dogs died after accidental ingestion of cottonseed bedding. No clinical signs of illness were observed prior to death. A full diagnostic workup was performed on one of these dogs. At necropsy, the lungs were congested and edematous, and the liver was firm, congested, and had a marked reticular
Recovery of normal testis function and sperm motility after cessation of gossypol treatment in hamster.
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The present investigations evaluate the reversibility of the effect of gossypol on the histoarchitecture of the hamster testis and the motility of the vas deferens spermatozoa. Adult male hamsters of proven fertility were treated orally with gossypol (10 mg/kg/day) for 13 weeks (group III). Another
[Effect of gossypol in combination with misoprostol on termination of early pregnancy in rats and mice].
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Treatment of mice with misoprostol alone at doses ranging from 200 to 6400 micrograms.kg-1, qid on day 6-8 or bid on day 9 of gestation, the rate of effective early pregnancy interruption were low and showed no dose effect relation. When giving misoprostol 200-6400 micrograms.kg-1 bid on day 9 of
Ultrastructural studies of spermatozoa and the epithelial lining of the epididymis and vas deferens in rats treated with gossypol.
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This study was undertaken to determine the effects at early time intervals of gossypol on sperm motility and on the ultrastructure of rat epididymal and vasal sperm and epididymal and vasal epithelium. Rats were treated by gavage with 20 or 30 mg/kg/day of gossypol for 7 weeks; control animals were
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