guanidine/mŕtvica

Odkaz sa uloží do schránky

ČlánkyKlinické štúdiePatenty

Vyberte typ zoradenia

Strana 1 od 19 výsledky

In vitro evaluation of guanidine analogs as sigma receptor ligands for potential anti-stroke therapeutics.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

Currently, the only Food and Drug Administration-approved treatment of acute stroke is recombinant tissue plasminogen activator, which must be administered within 6 hours after stroke onset. The pan-selective σ-receptor agonist N,N'-di-o-tolyl-guanidine (o-DTG) has been shown to reduce infarct

Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

The voltage-gated proton channel Hv1 plays important roles in proton extrusion, pH homeostasis, and production of reactive oxygen species in a variety of cell types. Excessive Hv1 activity increases proliferation and invasiveness in cancer cells and worsens brain damage in ischemic stroke. The

Copper-catalyzed guanidinylation of aryl iodides: the formation of N,N'-disubstituted guanidines.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

A copper-catalyzed cross-coupling reaction of guanidine nitrate with aryl iodides was used for the formation of N,N'-disubstituted guanidines to be used as potential therapeutics for strokes. A relatively inexpensive commercially available guanidine salt and a series of aryl iodides together with

Comparison of vasopressor effects of nitro arginine in stroke-prone spontaneously hypertensive rats and Wistar-Kyoto rats.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

1. NG-nitro-L-arginine (NO2Arg) is a guanidine nitro arginine derivative and an inhibitor of endothelium-dependent vascular relaxation. Significant rise of the systolic blood pressure was observed after 1 week administration of NO2Arg in food (0.023% in weight, about 2.8 mg of NO2Arg/rat per day) in

Subtype-specific modulation of acid-sensing ion channel (ASIC) function by 2-guanidine-4-methylquinazoline.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

Acid-sensing ion channels (ASICs) are neuronal Na(+)-selective channels that are transiently activated by extracellular acidification. ASICs are involved in fear and anxiety, learning, neurodegeneration after ischemic stroke, and pain sensation. The small molecule 2-guanidine-4-methylquinazoline

Creatine salts provide neuroprotection even after partial impairment of the creatine transporter.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

Creatine, a compound that is critical for energy metabolism of nervous cells, crosses the blood-brain barrier (BBB) and the neuronal plasma membrane with difficulty, and only using its specific transporter. In the hereditary condition where the creatine transporter is defective (creatine transporter

Prolinamide derivatives as thrombin inhibitors for the treatment of thrombin-mediated diseases: a patent evaluation of US2013296245.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

BACKGROUND Thrombotic disorders can lead to deep vein thrombosis, myocardial infarction and stroke. Thrombin plays a vital role in cascade reaction of blood coagulation, inhibition of the activity of thrombin can block the formation of thrombus and direct thrombin inhibitor has a prospect to

Factors affecting the stability and conformation of Locusta migratoria apolipophorin III.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

Apolipophorin III (apoLp-III) from the migratory locust, Locusta migratoria, represents the only full-length apolipoprotein whose three-dimensional structure has been solved. In the present study, spectroscopic methods have been employed to investigate the effects of deglycosylation (via

Synthesis and structure-activity studies of N,N'-diarylguanidine derivatives. N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: a new, selective noncompetitive NMDA receptor antagonist.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

Diarylguanidines, acting as NMDA receptor ion channel site ligands, represent a new class of potential neuroprotective drugs. Several diarylguanidines structurally related to N,N'-di-o-tolylguanidine (DTG), a known selective sigma receptor ligand, were synthesized and evaluated in in vitro

New CNS-specific calcium antagonists.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

Ischemic insults to the brain in stroke or traumatic brain injury produce excessive release of glutamate from depolarized nerve terminals. This excessive glutamate release in turn stimulates massive calcium entry into nerve cells, activating a biochemical cascade that results in cell death. A major

Synthesis and pharmacological evaluation of N-(2,5-disubstituted phenyl)-N'-(3-substituted phenyl)-N'-methylguanidines as N-methyl-D-aspartate receptor ion-channel blockers.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

In the mammalian central nervous system, the N-methyl-D-aspartate (NMDA) subclass of glutamate receptors may play an important role in brain diseases such as stroke, brain or spinal cord trauma, epilepsy, and certain neurodegenerative diseases. Compounds which specifically antagonize the actions of

Neuroprotective use-dependent blockers of Na+ and Ca2+ channels controlling presynaptic release of glutamate.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

We have originated a family of N,N'-disubstituted guanidines that block the voltage-activated Ca2+ and Na+ channels governing glutamate release. These compounds, CNS 1237 (N-acenaphthyl-N'-methoxynaphthyl guanidine) and its analogues, are "use dependent" in their ability to attenaute

Heteroarylguanidines as Allosteric Modulators of ASIC1a and ASIC3 Channels.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

Acid-sensing ion channels (ASICs) are neuronal Na+-selective ion channels that open in response to extracellular acidification. They are involved in pain, fear, learning, and neurodegeneration after ischemic stroke. 2-Guanidine-4-methylquinazoline (GMQ) was recently discovered as the first nonproton

sigma-1 receptor modulation of acid-sensing ion channel a (ASIC1a) and ASIC1a-induced Ca2+ influx in rat cortical neurons.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

Acid-sensing ion channels (ASICs) are proton-gated cation channels found in peripheral and central nervous system neurons. The ASIC1a subtype, which has high Ca2+ permeability, is activated by ischemia-induced acidosis and contributes to the neuronal loss that accompanies ischemic stroke. Our

Left ventricular function in terminal uremia. A hemodynamic and echocardiographic study.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

14 patients with advanced uremia had a mean cardiac index (CI) of 4.37 +/- 0.25 liters/min/m2, a mean stroke work index (SWI) of 65.6 +/- 3.7 g/m/m2 and a mean left ventricular filling pressure (LVFP) of 16.3 +/- 2.1 mm Hg. The left ventricular performance was estimated to be normal when CI or SWI

Predchádzajúce
1
2
Ďalšie

Pripojte sa k našej
facebookovej stránke

Herbal & Natural Medicine

Najkompletnejšia databáza liečivých bylín podporovaná vedou

Pracuje v 55 jazykoch
Bylinné lieky podporené vedou
Rozpoznávanie bylín podľa obrázka
Interaktívna GPS mapa - označte byliny na mieste (už čoskoro)
Prečítajte si vedecké publikácie týkajúce sa vášho hľadania
Vyhľadajte liečivé byliny podľa ich účinkov
Usporiadajte svoje záujmy a držte krok s novinkami, klinickými skúškami a patentmi

Zadajte príznak alebo chorobu a prečítajte si o bylinách, ktoré by vám mohli pomôcť, napíšte bylinu a pozrite sa na choroby a príznaky, proti ktorým sa používa.
* Všetky informácie sú založené na publikovanom vedeckom výskume