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Safety and Efficacy of Aspirin in Stroke Patients With Glucose-6-phosphate Dehydrogenase Deficiency (SAST)

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This SAST trial is a prospective, multicenter, randomized, double-blind trial.440 acute ischemic stroke (AIS) patients with G6PD deficiency will be randomized to receive a 3-month regimen of aspirin 100mg/d or clopidogrel 75mg/d. The primary end point is the proportion of protocol-defined hemolysis

Durvalumab as Maintenance Following Chemoradiation for Unresectable Esophageal Squamous Cell Carcinoma

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A) Study Title: Durvalumab (MEDI4736) as maintenance treatment following chemoradiation for locally advanced unresectable esophageal squamous cell carcinoma (DESC) B) Protocol Number: ESR-17-12757 C) Clinical Phase: 2 D) Study Duration: 36 months E) Investigational Product(s) and Reference Therapy:

One Year Hospital Data Patients With AIHA in Assiut University Hospital - Clinical Hematology Unit

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Hemolysis is the premature destruction of erythrocytes. A hemolytic anemia will develop if bone marrow activity cannot compensate for the erythrocyte loss. The severity of the anemia depends on whether the onset of hemolysis is gradual or abrupt and on the extent of erythrocyte destruction Hemolysis

Biomarker for Gilbert Disease (BioGilbert)

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Gilbert syndrome is a mild genetic liver disorder in which the body cannot properly process bilirubin, a yellowish waste product that is formed when old or worn out red blood cells are broken down (hemolysis). It is inherited as an autosomal recessive trait. Individuals with Gilbert syndrome have

A Comprehensive Care Plan for Pediatric Patients With Vaso-Occlusive Crises

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Sickle cell disease (SCD) disease is inherited as an autosomal recessive trait that results in several interactive processes: polymerization of hemoglobin S (HbS), hemolysis, nitric oxide depletion, and vaso-occlusion.[3] The most common manifestations of sickle cell disease are vaso-occlusive pain

Pyruvate Kinase Deficiency Natural History Study

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The purpose of the Pyruvate Kinase Deficiency (PKD) Natural History Study is to describe the natural history of PKD and the range and incidence of symptoms, treatments, and complications related to PKD. The study will collect retrospective medical history and routine clinical care data at baseline

The Effect of Antioxidant Vitamin Supplementation on Muscle Performance and Redox Status After Eccentric Training

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Historically there was a shift in the paradigm regarding the effects of antioxidant supplementation on muscle performance and redox status. In fact, back in the 80's and 90's most of the relevant studies reported "positive" effects of antioxidant supplementation on muscle performance, muscle damage

Transplantation of Umbilical Cord Blood Following Chemotherapy for Blood Cancers

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The success of BMT as a curative option for patients with malignancies is frequently limited by the inability to identify an appropriate donor in time for transplantation. Transplantations utilizing umbilical cord blood stem cells are increasingly successful. Data suggest that there are fewer and

Out Come Study To Define Laboratory Parameters That Are Best Suited to Diagnose Functional Iron Deficiency

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In dialysis patients the degree of anemia is highly correlated to both morbidity and mortality. A drop in Hb by 10 g/L translates into an increase in the rate of hospitalizations of 5 to 6 % and a rise in mortality by 4 to 5 %. The past two decades have seen great progress in the treatment of renal

Eculizumab in Treating Patients With Paroxysmal Nocturnal Hemoglobinuria

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OBJECTIVES: Primary - Determine the safety of eculizumab in patients with transfusion-dependent hemolytic paroxysmal nocturnal hemoglobinuria. - Determine the efficacy of this drug, in terms of hemoglobin stabilization and the number of packed red blood cell units transfused during the 26-week

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