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hexosamine/nekróza
Odkaz sa uloží do schránky
Strana 1 od 43 výsledky
[The behavior of hexosamine in cases of necrosis].
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Synthetic polysulfated hyaluronic acid is a potent inhibitor for tumor necrosis factor production.
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Based on the premise that naturally occurring glycosaminoglycans could serve as building blocks for synthesizing nontoxic drugs for suppression of tumor necrosis factor (TNF) production by inflammatory cells, we have chemically modified hyaluronic acid (HA) and tested its effects in blocking
Tumour necrosis factor-alpha selectivity modulates expression of collagen genes in rat granulation tissue.
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OBJECTIVE
To study the effects of tumour necrosis factor-alpha (TNF-alpha) on granulation tissue in rats.
METHODS
Animal experiment.
METHODS
University Hospital, Finland.
METHODS
48 rats in 6 groups.
METHODS
The test implants were treated with either a single or daily injections of 200 ng of
Mechanism of chlorogenic acid treatment on femoral head necrosis and its protection of osteoblasts.
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The aim of the present study was to investigate the therapeutic effect of chlorogenic acid on hormonal femoral head necrosis and its protection of osteoblasts. The study established a femoral head necrosis model in Wistar rats using Escherichia coli endotoxin and prednisolone acetate. The rats were
Beneficial contribution of a safflower (Carthamus tinctorius L.) polysaccharide on steroid-induced avascular necrosis of the femoral head in rats.
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A water-soluble polysaccharide (SPS) was purified from dried safflower (Carthamus tinctorius L.) and its structure was identified using a combination of chemical and instrumental analysis. SPS has a repeating backbone of 1,4,6-β-Glcp, which was attached with T-β-Glcp at its C6 position along the
Tumor necrosis factor alpha inhibits wound healing in the rat.
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This work was undertaken to study the effects of tumor necrosis factor-alpha (TNF-alpha/cachectin) on developing granulation tissue in rats. Cylindrical hollow sponge implants were used as an inductive matrix for the growth of granulation tissue. In the two test groups the implants were injected
Effect of antler extract on corticosteroid-induced avascular necrosis of the femoral head in rats.
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BACKGROUND
Deer antler, traditionally used as a tonic and valuable drug in oriental medicine, has been considered to possess bone-strengthening activity and effectively used in bone diseases therapy.
OBJECTIVE
The present study was designed to investigate therapeutic effect of antler extract on
[Response of the joint tissues to the presence of a foreign body implanted into the rabbit knee. A new model of experimental arthrosis].
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The joint tissues (synovium, articular cartilage and bone), respond rapidly and consistently to the presence of a piece of polypropylene surgically implanted into the Rabbit knee joint. In the contact of a foreign body, a synovium proliferates in an attempt to isolate and exclude the intruder from
N-butyryl glucosamine increases matrix gene expression by chondrocytes.
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Proteoglycan synthesis is dependent on N-acetyl glucosamine (GlcNAc) produced by the hexosamine biosynthetic pathway or obtained exogenously. Although used therapeutically to relieve symptoms of osteoarthritis, the actions of glucosamine and its analogs on cartilage are poorly understood. The
Decalepis hamiltonii inhibits tumor progression and metastasis by regulating the inflammatory mediators and nuclear factor κB subunits.
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Metastasis is an extremely complex process that is a major problem in the management of cancer. In the present study, we had evaluated the antimetastatic activity of DECALEPIS HAMILTONI: using B16F-10 melanoma-induced experimental lung metastasis in a C57BL/6 mice model.
UNASSIGNED
treatment
O-linked beta-N-acetylglucosamine during hyperglycemia exerts both anti-inflammatory and pro-oxidative properties in the endothelial system.
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Elevated cellular levels of protein O-linked beta-N-acetylglucosamine (O-GlcNAc) through hexosamine biosynthesis pathway (HBP) are suggested to contribute to cardiovascular adverse effects under chronic hyperglycemic condition associated with oxidative stress and inflammation. Conversely, enhancing
Chemical characterization and biologic properties of lipopolysaccharide from Bacteroides gingivalis strains W50, W83, and ATCC 33277.
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The chemistry and selected biological activity of lipopolysaccharide (LPS) from Bacteroides gingivalis strains W50, W83, and ATCC 33277 were compared, as well as the role of this molecule as a mediator of selected inflammatory responses. Chemically, the LPSs consisted of 47-58% Lipid A, 5-10%
Protective Effect of Solanum muricatum on Tumor Metastasis by Regulating Inflammatory Mediators and Nuclear Factor-Kappa B Subunits.
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Metastasis is one of the hallmarks of malignant neoplasm or cancer, which is the leading cause of death in many cancer patients. A major challenge in cancer treatment is to find better ways to specifically target tumor metastases. In this study, the anti-metastatic potential of the methanol extract
Antiulcer and gastroprotective effects of quercetin: a gross and histologic study.
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This study was designed to determine the cytoprotective properties of quercetin and the involvement of endogenous prostaglandins in mucosal injury produced by absolute ethanol. Gastric glands were also analyzed histologically. Oral pretreatment with the highest dose of quercetin (200 mg/kg), 120 min
Bone morphogenetic protein 15 and fibroblast growth factor 10 enhance cumulus expansion, glucose uptake, and expression of genes in the ovulatory cascade during in vitro maturation of bovine cumulus-oocyte complexes.
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Oocyte-secreted factors (OSFs) regulate differentiation of cumulus cells and are of pivotal relevance for fertility. Bone morphogenetic protein 15 (BMP15) and fibroblast growth factor 10 (FGF10) are OSFs and enhance oocyte competence by unknown mechanisms. We tested the hypothesis that BMP15 and
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