hyperalgesia/hemorrhage

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Post-needling Soreness After Internal Gastrocnemius Muscle Treatment

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Intervention: Two zones are established: - Zone 1: where researcher nº 1 controls the data management and sample randomization. - Zone 2: where researcher nº 2 locates the most hyperalgesic area and measures pressure point threshold variable and researcher nº 3 performs dry needling

Total Knee Replacement TIVA With Robotic Arm Assisted

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Preoperative Care Patients will be approached at the preadmission clinic or in the general ward before operation. The anaesthetic techniques will be explained and s/he will be recruited into the study if s/he agrees. Fasting will start 6 hours before surgery for solids and 2 hours clear fluid. All

Understanding the Pathophysiology of Migraine Pain

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The goals of the current study will be to demonstrate time-linked headache pain after super-selectively administration of vasodilatory medications to external carotid artery branches, and then observe vessel changes and presumed headache relief with transient occlusion of the same vessel. This work

DNA Methylation and Perioperative Pain Treatment

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During perioperative period surgical patients experience profound changes in their physiological processes. In addition to surgical stress, these variations are in part due to pharmacological treatments commonly used for anesthesia and analgesia during and after surgical procedure. Opioids are

Effect of the Uterotonic Carbetocin on Acute Post Cesarean-Section Pain

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Intraoperative Ketamine on Chronic Pain After Mastectomy

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Procedures Patients will be approached at the preadmission clinic or in the general ward before operation. The analgesic methods will be explained and s/he will be recruited into the study if s/he agrees. The patient will be randomized into one of three groups. The patients in the first group (C)

Analgesic Effect of Intraoperative Esmolol in Mastectomies

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Controlled hypotension is an anesthetic-surgical approach that matches the reversible and deliberate reduction in blood pressure during surgery period which aims to achieve values below 50% of normal values or mean arterial pressure (MAP) from 50 to 65 mmHg. This technique is especially beneficial

A Comparison of Intra-op Ketamine vs Placebo in Patients Having Spinal Fusion

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This is a prospective, single-blinded, placebo controlled single center trial. One hundred subjects (50 in each arm) will be enrolled. Subjects undergoing multilevel spinal fusion will be screened and have the study introduced and discussed with them during the preadmission visit. Subjects may also

The Effect of Induction Technique on Postoperative Pain and Agitation

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DIFFERENT INDUCTION TECHNIQUES ON AGITATION AND POSTOPERATIVE PAIN IN CHILDREN AFTER INGUINAL HERNIA AND CRYPTORCHIDISM Inguinal hernia and cryptorchidism are probably the most common operations in the paediatric age group. Inguinal hernia is the most common indication for surgery in the paediatric

Analgesic Effect of Oxytocin Receptor Modulation

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Background Chronic pain is still a largely unresolved issue, causing suffering, disability and high social costs. The search for novel pharmacological targets is therefore a priority. A recent study on postpartal bleeding came to the accidental finding of a possible analgesic action of the oxytocin

Intravenous Ibuprofen for Laparoscopic Bariatric Surgery

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Investigators will recruit patients scheduled for laparoscopic bariatric surgery at Jacobi Medical Center (100 patients with allowance for 20% drop-offs). Patients will be randomized to IV Ibuprofen versus placebo to test if morphine usage can be decreased, pain control improved, pressure pain

Treatment of Severe Mucositis Pain With Oral Ketamine Mouthwash

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Mucositis Mucositis is an adverse effect as a result of chemotherapy and radiation treatments and has significant quality of life and clinical consequences. Mucositis is a result of direct cytotoxic damage as well as a cytokine-mediated inflammatory response and can affect the epithelial mucosal

Assessment of Central Pain in the Peripartum Period

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Chronic pain is common. Up to 10% of the Population has been estimated to suffer from chronic pain and up to 5% of the female population has been estimated to suffer from widespread, chronic pain and tenderness, thus fulfilling American College of Rheumatology (ACR) criteria for classification of

Analgesia and Antihyperalgesia of Tramadol and Acetaminophen Per Oral After Caesarean Section

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Caesarean section rate is growing in western countries (from 9% by 1980, to 12% by 1990 up to 22-24% in 2002)1. Pain after Caesarean section involves 2 components, somatic pain from the wound and visceral pain from uterine contractions2. Different mechanisms underlie somatic and visceral pain

Headache in the Emergency Department (ED) - A Multi-Center Research Network to Optimize the ED Treatment of Migraines

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Parenteral Corticosteroids as Adjuvant Therapy for Migraine Headaches: A. Overview/Aims: Five million Americans present to emergency departments (ED) annually with headaches [1]. The majority of these patients have migraine headaches [2,3]. Parenteral medications of proven benefit for acute

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