The invention herein describes an improved and novel means of managing the complications of opioid analgesics, specifically treating the induction of emesis and itch by suppressing the activation of sensory afferent nerves. The composition of the botanical components that provides these benefits do not sacrifice hyperalgesia in order to negate the activity of sensory afferent nerves that drive emesis and itch, but in contrast affords significant analgesic actions in its own right. The combination of a therapeutic approach that negates an increased sensitivity to pain, itch, and nausea is a significant improvement over current treatment options.

Pharmaceutical preparations for the treatment of itch, nausea, hyperalgesia and the complications of opioid agonists

Disclosed are compounds having the general formula (I) ##STR00001## as defined herein, the preparation thereof, and the use thereof for the prophylaxis or treatment of any disease involving a dysfunction associated with the orexin 2 receptor such as obesity, appetite or taste disorders including cachexia, anorexia and bulimia, diabetes, metabolic syndromes, vomiting and nausea, depression and anxiety, addictions, mood and behaviour disorders, schizophrenia, sleep disorders, restless legs syndrome, memory learning disorders, sexual and psychosexual dysfunctions, pain, visceral or neuropathic pain, hyperalgesia, allodynia, digestive disorders, irritable bowel syndrome, neuronal degenerescence, ischaemic or haemorrhagic attacks, Cushing's disease, Guillain-Barre syndrome, myotonic dystrophy, urinary incontinence, hyperthyroidism, pituitary function disorders, hypertension or hypotension.

Sanofi Aventis

Sulphonamide derivatives, their preparation and their therapeutic application

The invention generally relates to compositions and methods with tramadol and an opioid antagonist to enhance analgesic potency and/or attenuate one or more adverse effects of tramadol, including adverse side effect(s) in humans such as nausea, vomiting, dizziness, headache, sedation (somnolence) or pruritis. This invention relates to compositions and methods for selectively enhancing the analgesic potency of tramadol and simultaneously attenuating anti-analgesia, hyperalgesia, hyperexcitability, physical dependence and/or tolerance effects associated with the administration of tramadol. The methods of the present invention comprise administering to a subject an analgesic or subanalgesic amount of tramadol and an amount of excitatory opioid receptor antagonist such as naltrexone or nalmefene effective to enhance the analgesic potency of tramadol and attenuate the anti-analgesia, hyperalgesia, hyperexcitability, physical dependence and/or tolerance effects of tramadol.

hyperalgesia/nauzea

Pharmaceutical preparations for the treatment of itch, nausea, hyperalgesia and the complications of opioid agonists

Sulphonamide derivatives, their preparation and their therapeutic application

Compositions and methods for enhancing analgesic potency of tramadol and attenuating its adverse side effects

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