hyperglycemia/protease

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A review of protease inhibitor-induced hyperglycemia.

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Hyperglycemia is an adverse effect that occurs with all protease inhibitors, although few cases have been reported in the literature. Most patients with human immunodeficiency virus infection receiving antiretroviral therapy are also taking at least one protease inhibitor. Patients with a family

Hyperglycemia associated with protease inhibitors in an urban HIV-infected minority patient population.

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BACKGROUND Hyperglycemia and new-onset diabetes mellitus have been reported to occur in HIV-infected patients treated with protease inhibitors. OBJECTIVE To determine the effect of protease inhibitor therapy on serum glucose in a predominantly minority patient population. METHODS Retrospective

Hyperglycemia potentiates carbonyl stress-induced apoptosis in naïve PC-12 cells: relationship to cellular redox and activator protease factor-1 expression.

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The mechanism(s) of central nervous system complication associated with neurodegenerative disorders such as diabetes is unknown. Previous studies demonstrated that carbonyl stress induced by methylglyoxal (MG) mediates differential apoptosis of rat pheochromocytoma (PC12) cells in the naïve or

Human obesity and thinness, hyperlipidemia, hyperglycemia, and insulin resistance associated with HIV1 protease inhibitors. Prevention by alternating several antiproteases in short sequences.

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In 1997, and mainly in 1998 and 1999, a lipodystrophic syndrome with central obesity, peripheral fat loss, hyperlipidemia, hyperglycemia and insulin-resistant-diabetes II, was described as the most frequent manifestation of toxicity of HIV1 virostatic therapy, associated with protease inhibitors

The efficacy of aldose reductase inhibitor, antioxidant butylated hydroxytoluene and cysteine protease inhibitor E64 on hyperglycemia-induced metabolic changes in the organ-cultured bovine lens.

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It is well known that polyol related sugar cataract formation is preventable with aldose reductase inhibitor (ARI) and newly developed different kinds of ARIs have been extensively studied for potential clinical use. The potency of AD-5467 ARI (Takeda) on hyperglycemic lenses was evaluated by

Protease inhibitor-associated hyperglycemia in Mexican patients with HIV infection.

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BACKGROUND The use of protease inhibitors has revolutionized the treatment of HIV infection. These agents are well tolerated, although the Federal Drug Administration (FDA) has warned U.S. doctors that protease inhibitors may precipitate hyperglycemia and diabetes (DM), based on isolated reports

[Lipodystrophy and hyperglycemia produced by protease inhibitors].

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BACKGROUND HIV-1 protease inhibitors (PI) have been recently associated with a syndrome of anomalous body fat distribution or lipodystrophy (LD), which sometimes is associated to hyperglycemia. Many aspects of this syndrome remain obscure. The objective of the study is to describe the prevalence,

High glucose concentrations impair the activation of K+ channels and proteases in undifferentiated THP-1 monocytes.

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Transient alkalization caused by activation of the BK(Ca) channels has been reported to be essential for the activation of proteolytic enzymes and bacterial killing in the leukocytic phagosomes. We investigated the effects of high glucose concentrations on these processes in THP-1 cells. While E.

Effects of protease inhibitors on hyperglycemia, hyperlipidemia, and lipodystrophy: a 5-year cohort study.

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BACKGROUND Although human immunodeficiency virus (HIV)-related morbidity and mortality rates in patients with advanced HIV infection who are treated with combination antiretroviral drugs have declined, significant metabolic adverse effects associated with these regimens have been increasingly

High glucose enhances thrombin responses via protease-activated receptor-4 in human vascular smooth muscle cells.

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OBJECTIVE Diabetes is associated with vascular remodeling and increased thrombin generation. Thrombin promotes vascular smooth muscle cell (SMC) mitogenesis and migration via protease-activated receptors (PAR)-1, PAR-3, and PAR-4. We investigated the effect of high glucose on expression and function

Hyperglycemia associated with protease inhibitors in HIV-1-infected patients.

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[Diabetes and hyperglycemia in patients under treatment for HIV infection with the protease inhibitors indavir, ritonavir, saquinavir as well as nelfinavir (in development, but not yet released].

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Health advisory: high blood sugar and diabetes seen in protease inhibitor users.

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Health advisory: high blood sugar and diabetes seen in protease inhibitor users.

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Protease-inhibitors linked with hyperglycemia in HIV-infected patients.

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