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hypesthesia/seizures
Odkaz sa uloží do schránky
Strana 1 od 20 výsledky
Ivermectin and Nitazoxanide Combination Therapy for COVID-19
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Selected Drugs
Ivermectin has anti-parasitic effect along with anti-viral activity against a broad range of viruses in vitro. Ivermectin was identified as an inhibitor of interaction between the human immunodeficiency virus-1 (HIV-1) integrase protein (IN) and the importin (IMP) α/β1 heterodimer
Hydroxychloroquine and Nitazoxanide Combination Therapy for COVID-19
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Selected Drugs
Hydroxychloroquine (an analog of chloroquine) has been demonstrated to have an anti-SARS-CoV activity in vitro. Hydroxychloroquine clinical safety profile is better than that of chloroquine (during long-term use) and allows higher daily dose and has fewer concerns about drug-drug
Systemic Absorption of Lidocaine After Hematoma Block
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When a subject with an eligible distal forearm fracture is identified, the subject will be approached for enrollment and consent. Fracture hematoma size will then be estimated using bedside ultrasound operated by trained pediatric emergency faculty or fellows. Ultrasound measurement of the
Metabolomic and Proteomic Profiles of Amniotic Fluid Embolism
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Thalamic Stimulation for Epilepsy Study
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The purpose of this research is to examine the physiologic underpinnings of deep brain stimulation of the anterior nucleus of the thalamus (ANT), a method reducing seizures in adults diagnosed with medically refractory epilepsy. In this study, the investigator aims to perform cortical stereo
Comparison of Clorotekal and Bupivacaine for Short Obstetric Surgery
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This will be a single-blind, randomized, controlled, single center clinical trial assessing the efficacy of spinal chloroprocaine on resolution of motor block and associated patient flow through the post-anesthesia care unit . Fifty patients will be equally randomized to receive either spinal
Does Preoperative Calcium and Calcitriol Decrease Rates of Post Thyroidectomy Hypocalcemia?
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The main objective of this study is to determine if treating patients with calcitriol and calcium prior to thyroidectomy decreases postoperative hypocalcemia. The primary outcome to be measured is clinical hypocalcemia, defined as peri-oral numbness and/or tingling, numbness and/or tingling in
Effects of Perampanel on Neurophysiology Test Perimeters
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The study drug used in this research study is perampanel, an FDA approved medication for the treatment of seizures. The study is being done to examine whether the study drug affects the following non-invasive tests of brain activity: electroencephalogram (EEG), visual evoked potential (VEP),
Multimodal Analgesic Technique for Control of Post-laproscopy Abdominal Pain
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The advancement of laparoscopy and minimal access surgery has greatly influenced the evolution of anaesthetic techniques. However, postoperative pain intensity may be significant, with up to 40% of patients unsatisfied by routine analgesia and up to 80%may require rescue opioids during their
Neostigmine Versus Dexamethasone as Adjuvants to Lidocaine During Intravenous Local Anesthesia
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This study will be a prospective clinical randomized controlled double-blind study using a computer-generated randomization. Neither the doctor "investigator" nor the participant "patient" will be aware of the group allocation or the drug used. The study drugs will be prepared by one of the
PK Study of EXPAREL in Subjects Undergoing Open Spinal Fusion or Reconstructive Surgery
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This is a Phase 1, multi-center, open-label study designed to evaluate the safety and pharmacokinetics of EXPAREL when administered via local wound infiltration to subjects undergoing open cervical or thoracic spinal fusion or reconstructive surgery.
Fifteen subjects are planned for enrollment.
Phase 4, Controlled Study in Adult Subjects Undergoing Primary, 1-2 Level, Open Lumbar Spinal Fusion Surgery
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This is a Phase 4, multicenter, randomized, double-blind, controlled study in approximately 220 adult subjects undergoing primary, 1-2 level, open lumbar spinal fusion surgery under general anesthesia.
Subjects will be screened within 30 days prior to study drug administration and at least one day
Lidocaine Infusion for Chronic Pain in Opioid Dependent Patients
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There is a significant disconnect between the escalating healthcare problem of opioid use for chronic pain, and the development of novel therapeutic strategies. A plausible strategy is to interrupt the vicious cycle of pain, inflammation and hyperesthesia is using highly efficacious non-opioid drugs
Pectoral Nerve Blockade in Mastectomy
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Randomization:
20 patients will be randomized into 2 groups. Both groups will receive paravertebral blocks with 4 mL of 0.5% ropivacaine at each of six levels.
Group A: Active group with 10 cc of 0.375% ropivacaine (16) pectoral nerve block Group S: Placebo group with 10 cc of normal saline for
Safety Study of Long-Acting Local Anesthetic
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Currently available amino amide local anesthetics (e.g. bupivacaine, levobupivacaine, ropivacaine) do not reliably provide analgesia beyond roughly 8 hours following subcutaneous infiltration. In addition, they can cause systemic toxicities such as seizures, arrhythmias, and cardiac arrest, as well
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