Modified Atkins diet will be administered with carbohydrate restriction to 10 grams per day. Proteins will be allowed unrestricted and fats will be actively encouraged.
The ongoing antiepileptic medication will be continued unchanged

The control group will continue their anti-epileptic medication unchanged with no additional dietary input

Epileptic Spasms

This is a modified version of the ketogenic diet where-in carbohydrates are restricted without any protein or calorie restriction.

Modified Atkins diet

Lady Hardinge Medical College

Evaluation of the Modified Atkins Diet in Children With Epileptic Spasms

Evaluation of the Modified Atkins Diet in Children With Epileptic Spasms Refractory to Hormonal Therapy: A Randomized Controlled Trial

The proportion of children who achieve spasm freedom for at least 48 hours as per parental reports at the end of 4 weeks will be evaluated in the both the groups

Proportion of children who achieved >50% reduction of clinical spasm, as per parental reports at 4 weeks, in both the groups.

Proportion of children who achieve resolution of hypsarrhythmia on electro encephalogram at 4 weeks in both the groups.

Description and proportion of the adverse effects of the diet as per parental reports in the diet group

Suvasini Sharma

Associate Professor

Modified Atkins diet arm-In this arm, the children will start the modified Atkins diet after a 4-week baseline period, during which daily seizure log will be maintained. Anti-epileptic medications will remain unchanged during the 3 month trial period, unless the change in AED regimen is medically indicated; e.g. drug side effects or status epilepticus; in which case standard therapy will be provided.

No Intervention arm- After the 4-week baseline period, this group will receive their normal diet with no dietetic input, and remain on the same on-going antiepileptic medication for the 3 months. Anti-epileptic medications will remain unchanged during the 3 month trial period, unless the change in AED regimen is medically indicated; e.g. drug side effects or status epilepticus; in which case standard therapy will be provided.
At the end of three months, patients in this arm will be offered the option of the modified Atkins diet treatment.
This group will not receive any dietetic input

Refractory Childhood Epilepsy

Modified Atkins Diet administration
Carbohydrates intake will be restricted to 10 grams/ day. (Carbohydrate values of various food items will be explained in detail, and exchange lists provided. Four 2.5 grams carbohydrate exchange items will be allowed in a day.)
Fats (e.g. cream, butter, oils, ghee) encouraged.
Proteins (cheese, fish, eggs, chicken, soya products) unrestricted.
Clear carbohydrate-fluids not restricted.
Calcium and multivitamin supplementation will be provided.

hypoproteinemia/carbohydrate

Evaluation of the Modified Atkins Diet in Children With Epileptic Spasms

Modified Atkins Diet in Childhood Epilepsy

Najkompletnejšia databáza liečivých bylín podporovaná vedou