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Strana 1 od 180 výsledky
N-substituted-(Dihydroxyboryl)alkyl purine, indole and pyrimidine derivatives, useful as inhibitors of inflammatory cytokines
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BACKGROUND OF THE INVENTION
Tumor necrosis factor alpha (TNF-.alpha.), also known as cachectin, is a 17 kDa protein produced by neutrophils, activated lymphocytes, macrophages, NK cells, LAK cells, astrocytes, endothelial cells, smooth muscle cells, and some transformed cells. A large number of
Biologically active compound N-[3-(4-nitrophenylamino)-indole-2-ilmethylene]aminoguanidine hydrochloride with anti-inflammatory activity
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CROSS REFERENCE TO RELATED APPLICATION
This application is a U.S. National Phase of International Application No. PCT/RU2011/000142 filed on Mar. 11, 2011, which claims priority to and the benefit of Russian Patent Application No. 2010109357 filed on Mar. 15, 2010, the entire contents of which are
Indole alkaloids useful as UV protective and anti-inflammatory agents
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates generally to compounds which have more than one pharmaceutically desirable activity. More particularly, the present invention is directed to a newly isolated indole alkaloid compound and analogs thereof which have
Indole alkaloids useful as UV protective and anti-inflammatory agents
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates generally to compounds which have more than one pharmaceutically desirable activity. More particularly, the present invention is directed to a newly isolated indole alkaloid compound and analogs thereof which have
[1-(P-Chlorobenzoyl)-5-methoxy-2-methyl-3-indole]acetoxyacetic acid and salts in treating inflammation
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The present invention relates to a novel [1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indole]-acetoxyacetic acid and its salts formed with pharmacologically acceptable bases. The invention further relates to processes for the production of the new compound and its use in medicines, more particularly in
Indoles useful in the treatment of inflammation
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This is a .sctn.371 national phase conversion of PCT/GB2005/004981, filed Dec. 22, 2005, which claims priority benefit of U.S. Provisional Application No. 60/644,558, filed Jan. 19, 2005.
FIELD OF THE INVENTION
This invention relates to novel pharmaceutically-useful compounds, which compounds are
Indoles useful in the treatment of inflammation
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FIELD OF THE INVENTION
This invention relates to novel pharmaceutically-useful compounds, which compounds are useful as inhibitors of enzymes belonging to the membrane-associated proteins in the eicosanoid and glutathione metabolism (MAPEG) family. Members of the MAPEG family include the microsomal
Substituted 1-(4-aminophenyl)indoles and their use as anti-inflammatory agents
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BACKGROUND OF THE INVENTION
It has been well established that T-cells play an important role in regulating immune response (F. Powrie and R. L. Coffman, Immunol. Today, 1993, 14, 270). Indeed, activation of T-cells is often the initiating event in many inflammatory and autoimmune diseases. IL-2 is
Anti-inflammatory indole derivatives
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The present invention relates to chemical compounds, to their production as well as to pharmaceutical compositions containing them as well as to their use in therapy, in particular of inflammatory disease.
MCP-1 is a member of the chemokine family of pro-inflammatory cytokines which mediate
Amorphous (quinolin-2-ylmethoxy)indole compounds useful for treating inflammatory diseases
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BACKGROUND OF THE INVENTION
EP 419,049, Prasit et al., Mar. 27, 1991, describes a series of quinolin-2-ylmethoxy indoles useful as inhibitors of leukotriene biosynthesis. Examples 1 and 1A therein teach the synthesis of 3-[N-(p-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-ylmethoxy)indol-2-yl]-
Indole compounds for use in treating inflammation and cancer
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TECHNICAL FIELD
This disclosure generally relates to indole compounds for use in treating inflammation and cancer, including the indole compounds themselves, pharmaceutical compositions comprising the indole compounds, and methods for using the indole compounds and pharmaceutical compositions to
Anti-inflammatory indole derivatives
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This application is a 371 of PCT/GB00/00275 Jan. 31, 2000 now WO 00/46198.
The present invention relates to chemical compounds, to their production as well as to pharmaceutical compositions containing them and to their use in therapy, in particular of inflammatory disease.
MCP-1 is a member of the
Indole derivatives as anti-inflammatory agents
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to anti-inflammatory and analgesic compounds, especially to certain indole derivatives, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
2. Background of the
Indole derivatives as anti-inflammatory agents
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BACKGROUND OF THE INVENTION
Field of the Invention
This invention relates to anti-inflammatory and analgesic compounds, especially to certain indole derivatives, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
BACKGROUND OF THE
Indole derivatives as anti-inflammatory agents
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to anti-inflammatory and analgesic compounds, especially to certain indole derivatives, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
2. Background of the
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