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13 výsledky

Biomarkers of Broccoli Intake: A Pilot Study

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Consumption of Brassica vegetables is inversely associated with incidence of several cancers, including cancer of the lung, stomach, liver, colon, rectum, breast, endometrium, and ovaries. Brassicas are a good source of many nutrients, but the unique characteristic of Brassicas is their rich content

Metabolic Consequences of Gastrointestinal Surgery

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The role of the gut hormone axis in glucose control is of significant interest due to its proven translational impact in diabetes management. It is also significantly altered by gastric surgery, a procedure that can lead to deleterious symptoms (dumping syndrome) in lean, non-diabetic patients. The

The Indol Profile; Exploring the Metabolic Profile of Neuroendocrine Tumors

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Rationale: Neuro-endocrine neoplasms are a diverse group of tumors which encompasses heterogeneous clinical courses. Different NETs are characterized by differences in the synthesis, storage and release of biogenic amines and their metabolites, e.g. indoles, catecholamines and their metabolites.

Effectiveness of DIM Supplements to Increase 2-OHE1/16 Ratio

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The purpose of this study was to evaluate the effectiveness of supplementation with 3,3´-Diindolylmethane (DIM) to increase the urinary ratio of estrogen metabolites 2OHE1:16alphaOHE1 (RMEU) in women at risk of breast cancer to contribute to generate a tool of early prevention of this

A Phase II Single-arm Intervention Trial of Nelfinavir in Patients With Grade 2/3 or 3 Cervical Intraepithelial Neoplasia

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2.0 BACKGROUND AND RATIONALE 2.1 Cervical Cancer Etiology and Targets for Intervention Cervical cancer is one of the most common causes of cancer-related deaths in women worldwide. Implementation of widespread screening has created drastic improvements in the incidence of cervical cancer as well as

A Multipeptide Vaccine Plus Toll-Like Receptor Agonists in Melanoma Patients

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Goals: 1. To determine the safety of intradermal and subcutaneous injection of lipopolysaccharide (LPS) as a vaccine adjuvant with a multipeptide vaccine. 2. To obtain preliminary data on whether administration of a multipeptide vaccine plus each of 2 TLR agonists is immunogenic with or without

Starch-entrapped Microspheres [Nutrabiotix Fiber] for Gut Health

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The long-term objective of our research program is to show that targeted colonic delivery of natural specific fermentable carbohydrates will maintain and promote gut health by changing the gut microbiota [prebiotic effect], by increasing "protective and growth promoting" factors such as butyrate,

Development and Exploration of the Feasibility of Using Locally Synthesized Small Molecule Inhibitors to Treat Human Acute Leukemia Cells

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Plant Extracted Natural Compounds Impact on Stage IV Breast Cancer Survival Time and Remission.

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OBJECTIVES: To utilize multiple naturally-occurring bioalkaloids, bioactive "compounds of interest" from multiple sources, to influence prostate, breast, and uterine cancer pathways in cancer patients and cancer patients in remission. Other cancer types may be applicable. To utilize specific

Brassica Vegetables or Indole-3-Carbinol in Treating Patients With PSA Recurrence After Surgery for Prostate Cancer

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OBJECTIVES: - Determine the feasibility of Brassica vegetable intake and indole-3-carbinol supplement use in patients with prostate cancer with prostate-specific antigen (PSA) recurrence after prostatectomy. - Identify adverse events in these patients. - Quantify the effects of each intervention on

Effects of Brassica or Indole-3-carbinol on Prostatectomy Patients With PSA Recurrence

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Indole-3-Carbinol in Preventing Cancer in Healthy Participants

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OBJECTIVES: Primary - Determine the maximum tolerated dose of indole-3-carbinol in healthy participants. - Determine the safety and tolerability of this drug in these participants. - Determine the pharmacokinetics of this drug in these participants. Secondary - Determine the effects of this drug on

Indole-3-Carbinol in Preventing Breast Cancer in Nonsmoking Women Who Are at High Risk For Breast Cancer

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OBJECTIVES: - Determine the safety and tolerability of indole-3-carbinol for the prevention of breast cancer in non-smoking women at high risk for breast cancer. - Determine the pharmacokinetics of this drug in these participants. - Determine the effect of this drug on metabolites of estrogen in

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