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Strana 1 od 86 výsledky
Morphology of noncardiogenic pulmonary edema induced by Perilla ketone in sheep.
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A single infusion of Perilla ketone (PK) into sheep causes marked increases in lung fluid and solute exchange in the absence of any alteration in either pulmonary arterial or left atrial pressures. These alterations are most compatible with increased pulmonary microvascular permeability. The present
Perilla ketone: a model of increased pulmonary microvascular permeability pulmonary edema in sheep.
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A model of increased microvascular permeability pulmonary edema was developed in chronically instrumented unanesthetized sheep using perilla ketone (PK). PK did not cause changes in pulmonary hemodynamics but did cause marked increases in the flow of protein-rich lung lymph. The changes in lung
Observations on the effects of chemical configuration on the edema-producing potency of acids, aldehydes, ketones and alcohols.
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Synthesis and anti-inflammatory activity of fluorinated phenyl styryl ketones and N-phenyl-5-substituted aryl-3-p-(fluorophenyl) pyrazolins and pyrazoles.
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Various N-phenyl-5-substituted aryl-3-p-(fluorophenyl) pyrazolins and pyrazoles were synthesized by cyclization of the corresponding 4-(fluorophenyl) styryl and 4-(fluorophenyl) dibromostyryl ketones. These compounds were characterized by elemental analysis and UV, infrared, and nuclear magnetic
The fixed structure of Licochalcone A by alpha, beta-unsaturated ketone is necessary for anti-inflammatory activity through the inhibition of NF-kappaB activation.
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Glycyrrhiza inflata has been used as a traditional medicine with anti-inflammatory activity. Previously, we reported that a major component, Licochalcone A, potently inhibited TNFalpha-induced NF-kappaB activation by inhibiting IKKbeta activation. In this study, we investigated whether the fixed
Edema-inducing effects of solvents following topical administration.
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It was demonstrated in a previous study that skin irritancy reactions could be accurately assessed by skin-fold measurements using a caliper. Eight solvents (trichloroethylene, toluene,1,1,2- trichloroethane, carbon tetrachloride, 1,1,1-trichloroethane,n-hexane, methyl ethyl ketone, ethanol--all
[Pathological changes of major organs after rats inhaled methyl ethyl ketone peroxide aerosol].
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OBJECTIVE
To investigate the pathological changes of major organs in rats that have inhaled methyl ethyl ketone peroxide (MEKP) aerosol and to provide clues to the oxidative damage mechanism of MEKP.
METHODS
A total of 100 Sprague-Dawley rats (male-to-female ratio = 1:1) were randomly and equally
Sudden death of a 15-year-old girl due to fulminant type 1 diabetes mellitus-diabetic ketoacidosis induced cerebral edema?
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Sudden death from fulminant type 1 diabetes mellitus is uncommon in forensic practice. Here we report the sudden death of a 15-year-old girl who presented with vomiting, fever and abdominal pain and died unexpectedly. Postmortem examination showed severe pancreatic islet destruction, cerebral edema
Narrowing of airway caused by ingestion of methyl ethyl ketone peroxide.
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Although ingestion of methyl ethyl ketone peroxide (MEKP) is rare, it carries a high risk of morbidity and mortality. This paper reports the first such case from Turkey in which a 70-year-old man unintentionally ingested MEKP in his kitchen. The patient was brought into the emergency department (ED)
Perilla ketone increases endothelial cell monolayer permeability in vitro.
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Perilla ketone (PK) is a potent lung toxin that causes increased microvascular permeability pulmonary edema in grazing animals. Because the mechanism of action of PK is not know, we investigated whether PK directly affects endothelial cells. Bovine aortic endothelial cells were grown to confluence
Effects of Perilla ketone on the in situ sheep lung.
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We studied the effects of three different doses (15, 20, and 25 mg/kg) of Perilla ketone (PK) on the blood-perfused in situ sheep lung while obtaining external measurements of lung transvascular protein flux. Lymph flow and lymphatic protein clearance increased significantly after all doses of PK.
Correlation between increased airway responsiveness and severity of pulmonary edema.
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To determine whether the severity of the pulmonary edema in sheep models of cardiogenic and non-cardiogenic pulmonary edema correlate with concomitant alterations in airway responsiveness using three separate measures of pulmonary edema: post-mortem wet-to-dry lung weight ratio (W/D), chest
Effect of cardiogenic and noncardiogenic pulmonary edema on histamine responsiveness in sheep.
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We compared the effects of cardiogenic pulmonary edema, brief pulmonary vascular congestion without frank edema, and noncardiogenic pulmonary edema on responsiveness to inhaled histamine in chronically instrumented awake sheep. Histamine responsiveness was measured before and after 1) cardiogenic
Comparison of the pulmonary dysfunction caused by cardiogenic and noncardiogenic pulmonary edema.
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We designed a series of experiments to compare the pulmonary dysfunction observed in models of cardiogenic and noncardiogenic pulmonary edema in chronically instrumented awake sheep. Cardiogenic pulmonary edema was induced by inflating the balloon of a Foley catheter surgically positioned in the
Effect of pulmonary edema on tracheal diameter.
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BACKGROUND
Though it is well known that cardiogenic and noncardiogenic pulmonary edema can cause changes in lung mechanics, actual alterations in tracheal diameter have not been described.
OBJECTIVE
To evaluate the effects of pulmonary edema induced by increased left atrial pressure (cardiogenic)
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