The infected group will be classified according to the severity whether mild ,moderate or severe

This group either exposed and not infected .

Biological sample will take for the following analysis 1. Routine diagnostic analysis Routine Laboratory testing includes complete blood picture (CBC), C-reactive protein (CRP), liver function tests, Blood sugar, serum creatinine 2. Routine molecular diagnostic analysis Routine molecular Laboratory testing includes Real-time PCR Detection for SARS-COV 2 3. Laboratory investigation for candidate gene i. Nucleic Acid Extraction from peripheral blood: the first step will include High-quality total nucleic acid extraction covering DNA, RNA, non-coding RNA, and Micro RNA ii. Allelic discrimination using ABI 7500 real-time PCR. The host DNA will be genotyped for candidate genes using TaqMan® SNP genotyping assays

Genetic Predisposition to Disease

Mansoura Faculty of Medicine

Immunogenetics Predictors With COVID-19

Various Molecular Markers With Predictive and Prognostic Significance in COVID-19 Outcome

To assess genetic mutation via detection of genetic polymorphisms of ACE2 in patients and control to detect what alleles will be associated with the susceptibility to COVID-19 and what alleles will be associated with clearance or protection from infections. using allelic discrimination SSCP (i.e Real-time PCR and genetic sequencer).

Mahmoud Elbendary

Professor of Tropical Medicine and Hepatogastroenterology

Mansoura University

Fever, Sweats, and Hot Flashes

Infection

Leukemia

Lymphoma

Myelodysplastic Syndromes

Neutropenia

Unspecified Childhood Solid Tumor, Protocol Specific

recombinant human mannose-binding lectin

Children's Hospital of Orange County

Children's National Medical Center

Children's Hospital of Philadelphia

Recombinant Human Mannose-Binding Lectin (MBL) in Treating Young Patients With MBL Deficiency and Fever and Neutropenia

A Multi-Center Study of the Safety, Tolerability, Pharmacokinetics and Dose Escalation of Intravenous Recombinant Human Mannose-Binding-Lectin (rhMBL) in MBL Deficient Pediatric Hematology/Oncology Patients With Fever and Neutropenia

lectin/horúčka

Immunogenetics Predictors With COVID-19

Recombinant Human Mannose-Binding Lectin (MBL) in Treating Young Patients With MBL Deficiency and Fever and Neutropenia

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