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Strana 1 od 33 výsledky
The Role of Galectins in the Non-invasive Diagnosis of Endometriosis
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Endometriosis is one of the most common infertility-related gynecologic disorder that affect approximately 10-15% of women in reproductive age. The main symptoms are chronic pelvic pain, infertility, dysmenorrhea and dyspareunia. The etiology and pathogenesis of endometriosis has been widely
Immunogenetics Predictors With COVID-19
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There is a current worldwide outbreak of the novel coronavirus Covid-19 (coronavirus disease 2019; the pathogen called SARS-CoV-2; previously 2019-nCoV), which originated from Wuhan in China and has now spread to 6 continents including 210 countries. Coronaviruses (CoVs), is a large family of
Evaluation of Interleukine 6 (and Other Cytokines and Inflammatory Markers) in COVID-19 Patients With a Systemic Inflammatory Response Syndrome
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In patients with severely progressive SARS-Cov-2 Coronavirus infection, the elderly and immunocompromised are at greater risk of progressing to a serious image of ARDS (Acute Respiratory Distress syndrome). A recent study has shown that patients, sometimes young, requiring hospitalization in
Evaluation of New Biomarker-based Approaches for Improving the Diagnosis of Childhood Tuberculous Meningitis
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IMPORTANCE AND RELEVANCE TO EDCTP2 Despite considerable ongoing efforts in the development of tools to combat tuberculosis (TB), the disease was responsible for approximately 1.6 million deaths, with 10 million people developing the disease worldwide in 2017 (1). An estimated one million children
The Role of Emergency Neutrophils and Glycans in Postoperative and Septic Patients
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Postoperative complications of any sort occurs in many of the patients undergoing high risk cancer surgery such as surgery for pancreatic, esophageal or ovarian malignancy (3, 4) These patients have a risk of wound infection mainly due to malnutrition and challenging surgical conditions (5, 6) A
MBL Level in Women With Recurrent Miscarriage and Its Association With Perinatal Outcome
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Recurrent pregnancy loss (RPL), defined as 3 or more consecutive pregnancy losses before 22 weeks of gestation, is a multifactorial disorder, affecting 1-3% of all couples aiming to have a child. The cause of RPL remain unknown in up to 50% of cases. Some of these cases may be affected by an
Clinically Isolated Syndrome and Relapsing-Remitting Multiple Sclerosis
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The goal of this project is to compare a diet and therapeutic lifestyle only treatment usual care in the setting of newly diagnosed individuals with RRMS or CIS, which is the precursor to the development of MS. The current standard of care typically includes disease-modifying drug treatment at the
Aloe Vera Ointment Application and Skeletal Muscle Recovery
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For the purpose of study, ten male participants will be included in a pilot clinical trial.
Initially, participants will undergo a baseline testing including assessment of body height, body mass and body composition, isokinetic evaluation of isometric, concentric and eccentric muscle strength of
Oxidized LDL With Oxygen Therapy in Acute Coronary Syndrome.
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Cardiovascular disease, which is multifactorial and caused by complex interactions of genetic and environmental factors, represents the main cause of death all over the world. Traditional risk factors for coronary atherosclerosis include age, smoking, male gender, hypertension and diabetes. Newly
Anti-ficolin-3 Antibodies in Lupus Nephritis
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PRIMARY OUTCOME MEASURE Exploration of the inhibition of anti-ficolin-3 antibodies purified from the serum of 14 patients with active lupus nephritis in ficolin-3-dependent necrotic cells recognition.
The criterion used is the shift of MFI (Mean Fluorescence Intensity) measured after addition of
Biodistribution, Dosimetry and Performance of [68Ga]Ga-DOTA-Siglec-9 in Healthy and Patients With Rheumatoid Arthritis
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Vascular adhesion protein 1 (VAP-1) is an inflammation inducible endothelial cell molecule mediating leukocyte trafficking from blood into the sites of inflammation. Although VAP-1 plays important role in early phases of inflammation, its luminal expression on the endothelium will remain constant if
Influence of Periodontal Disease Treatment on Serum Levels of Sirtuin 1 and Mannose-binding Lectin
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Inclusion criteria for PD were: presence of at least 15 teeth and clinical diagnosis of PD. Excluding third molars. This diagnosis was confirmed by the presence of at least 6 teeth with at least one noncontiguous interproximal site with Probing Pocket Depth (PPD) and Clinical Attachment Loss (CAL) ≥
Cardiovascular Disease Risk in Women With Endometriosis
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Our scientific premise is that in women with endometriosis, elevated cardiovascular disease risk is the result of endothelial dysfunction and chronic systemic inflammation through lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) receptor activation. This cardiovascular disease risk is
Serum and Bronchoalveolar Inflammatory Parameters in Patients With Severe Adult Respiratory Distress Syndrome
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Mannose-binding lectin (MBL) plays an important role in the innate immune response. In addition to activating the complement, MBL can induce cytokine production and contribute to a deleterious inflammatory response with severe A(H1N1)pdm09 virus infection. The aim was to determine if serum MBL
Use of Fc-MBL to Detect and Monitor the Presence of PAMPs During Septic Shock
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Septic shock still represent a major cause of admission in intensive care unit, incidence of severe sepsis is increasing, even in western countries, due to aging populations and comorbidities. Definition of septic shock was revised in 2016 by a task force, which emphasizes the need for future
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