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Fat necrosis of transverse colon and necrotizing pancreatitis in a patient with acute lymphoblastic leukemia (ALL): cause of massive ascites and high fever.

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We report a nine-year-old boy with acute lymphoblastic leukemia L3 (ALL-L3) and necrotizing pancreatitis in which necrosis was not limited to the pancreas. As our patient had a defective inflammatory process as a result of underlying malignant disease and neutropenia, the peripancreatic collection

The synergistic reversal effect of multidrug resistance by quercetin and hyperthermia in doxorubicin-resistant human myelogenous leukemia cells.

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OBJECTIVE This study aimed to evaluate the multidrug resistance (MDR) reversal activity of quercetin (Que) in combination with hyperthermia (HT) in human myelogenous leukemia cells K562/A. METHODS The cytotoxicity of Que alone and the effect of Que and HT to doxorubicin (Dox) cytotoxicity were

Neutropenia, fever, and infection in children with acute lymphocytic leukemia.

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In an attempt to determine the relationship between neutropenia (absolute granulocyte count less than 1,000/cu mm), infection, and disease status, 20 patients with acute lymphoblastic leukemia were observed for a total of 34 patient-years. Febrile episodes occurred with much greater frequency in

Sensitization of chronic lymphocytic leukemia cells to TRAIL-induced apoptosis by hyperthermia.

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We recently reported that, in cultured leukemic T lymphocytes and promyelocytic cells, a mild heat shock treatment (1 h at 42 degrees C) induced a long lasting stimulation of the apoptosis induced by TNF-related apoptosis inducing ligand (TRAIL). On the opposite, no effects were recorded toward

Dengue fever causing febrile neutropenia in children with acute lymphoblastic leukemia: an unknown entity.

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Dengue fever is endemic in many parts of the world but it has not been described as a cause of febrile neutropenia. We describe here clinical features, laboratory values and outcome in 10 children with acute lymphoblastic leukemia (ALL) and with dengue fever as a cause of febrile neutropenia. These

Interactions between hyperthermia and irradiation in two human lymphoblastic leukemia cell lines in vitro.

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Thermal radiosensitization was studied in two human T-cell acute lymphoblastic leukemia cell lines (JM and MOLT3) with regard to heat-irradiation sequence and heating duration. In MOLT3 thermal radiosensitization was maximal when 43.5 degrees C hyperthermia immediately preceded or followed

Hematopoietic recovery in a patient with acute lymphoblastic leukemia after an autologous marrow graft purged by combined hyperthermia and interferon in vitro.

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We describe a patient with acute lymphoblastic leukemia (ALL) in whom hemopoiesis recovered after an autologous marrow graft purged by in vitro hyperthermia. A 17-year-old woman was diagnosed as having ALL in April 1985. After clinical remission was induced, marrow cells were harvested. The marrow

Congenital leukemia presenting as fever in a neonate.

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BACKGROUND Emergency department workup of pediatric fever typically focuses on ruling out serious bacterial infection, but other disease processes can cause fever. Congenital leukemia is a rare but important cause of fever in neonates. We review the presentation, pathophysiology, and potential

Fever in children with acute lymphoblastic leukemia.

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In this study among children with acute lymphoblastic leukemia, more febrile episodes occurred during induction of remission and relapse than during remission. Infection was mainly responsible for fever during remission, regardless of the neutrophil count. However, during induction and relapse,

Severe combined immunodeficiency syndrome, tissue transplant, leukaemia, and Q fever.

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A child born with severe combined immunodeficiency, who was immunoreconstituted by a fetal liver and thymus transplant, developed acute lymphoblastic leukaemia in the donor cell line. During remission she contracted acute Q fever, which gave rise to unexpected complications. Early treatment of the Q

Significant contribution of Fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in a case of acute lymphoblastic leukemia presenting with fever of unknown origin.

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The diagnostic value of fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) has not been thoroughly evaluated in patients with leukemia. We herein report the case of a patient with B cell acute lymphoblastic leukemia (ALL) presenting with fever of unknown origin (FUO)

Persistent spiking fever in a child with acute myeloid leukemia and disseminated infection with enterovirus.

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We here report a 7 year old acute myeloid leukemia patient with persistent spiking fever likely caused by chronic echovirus 20 infection. After immunoglobulin substitution fevers subsided and the virus was cleared. Enterovirus infection should be considered in immunocompromised patients with

Prolonged fever of unknown origin and hemophagocytosis evolving into acute lymphoblastic leukemia.

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Hemophagocytic syndrome (HPS) is an unusual acute syndrome presenting with fever, hepatosplenomegaly, and cytopenias. The hallmark of HPS is the accumulation of activated macrophages that engulf hematopoietic cells in the reticuloendothelial system. Most cases of HPS in adults are secondary to

A prospective, open-label noncomparative study with piperacillin-tazobactam monotherapy as management of fever in patients with acute leukemia.

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We evaluated the efficacy of piperacillin-tazobactam monotherapy as empiric therapy of fever in acute leukemia patients in a total of 80 consecutive febrile episodes. The overall success rate was 75% with success without modification in 34% (afebrile at 72 h) and an overall death rate of 10%. No

Fever in acute myelogenous leukemia.

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Implications and course of fever were evaluated during hospitalization of 24 patients with acute myelogenous leukemia. Forty-five febrile episodes were identified. Fever present at admission was usually associated with a diagnosable and treatable infection; fever shortly after induction was

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