malic enzyme/zhubný nádor

Odkaz sa uloží do schránky

Vyberte typ zoradenia

Strana 1 od 26 výsledky

Tumor-induced alterations in hepatic malic enzyme and carnitine palmitoyltransferase activity.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

To better understand the role of the liver in the hypertriglyceridemia observed in a tumor-bearing state, we have examined tumor-induced alterations in hepatic lipogenesis and fatty acid oxidation. The effects of differing tumor burden as well as tumor excision on the activity and mRNA levels of

Malic Enzyme 1 Indicates Worse Prognosis in Breast Cancer and Promotes Metastasis by Manipulating Reactive Oxygen Species

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

Purpose: Malic enzyme 1 (ME1) catalyzes malate to pyruvate and thus promotes glycolysis. Its function in breast cancer remains to be fully clarified. The aim of this work was to investigate the prognostic value of ME1 and its possible

Inhibition of malic enzyme 1 disrupts cellular metabolism and leads to vulnerability in cancer cells in glucose-restricted conditions.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

Malic enzyme 1 (ME1) regulates one of the main pathways that provide nicotinamide adenine dinucleotide phosphate (NADPH), which is essential for cancer cell growth through maintenance of redox balance and biosynthesis processes in the cytoplasm. In this study, we found that ME1 inhibition disrupted

Malic enzyme 2 as a potential therapeutic drug target for cancer.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

Reprogrammed metabolic profile is a biochemical fingerprint of cancerous cells, which represents one of the "hallmarks of cancer." The aberrant expression pattern of enzymatic machineries orchestrates metabolic activities into a platform that ultimately promotes cellular growth, survival, and

Dietary soy protein induces hepatic lipogenic enzyme gene expression while suppressing hepatosteatosis in obese female Zucker rats bearing DMBA-initiated mammary tumors.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

Fatty liver is associated with obesity and breast cancer. We used an obese rat model of mammary cancer to examine whether hepatosteatosis is modifiable by diet and associated with altered expression of hepatic lipogenic enzyme genes, thyroid hormone system genes and cholesterol metabolism-related

The possible role of TNF-alpha and IL-2 in inducing tumor-associated metabolic alterations.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

This study was conducted to investigate the role of tumor necrosis factor-alpha (TNF-alpha) and interleukin-2 (IL-2) in inducing cancer cachexia, and the results were compared with those obtained from our previous study on Fisher 344 rats with methylcholanthrene-induced sarcoma. Three groups of male

The effects of a biological response modifier, OK-432, on tumor-induced alterations in the host metabolism.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

The effects of multicytokine inducer, OK-432, on tumor-induced metabolic alterations were studied by assessing three key regulatory enzymes of gluconeogenesis, de novo fatty acid synthesis and the triglyceride clearance pathways. Two Klinish Einheit (KE) of OK-432 was subcutaneously injected on

The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

The high-mobility group box 1 (HMGB1) protein has a central role in immunological antitumour defense. Here we show that natural killer cell-derived HMGB1 directly eliminates cancer cells by triggering metabolic cell death. HMGB1 allosterically inhibits the tetrameric pyruvate kinase isoform M2, thus

Effect of tumors with different growth rates on enzymes in host liver.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

In response to extrahepatic neoplasms, ornithine aminotransferase, malic enzyme, alanine aminotransferase and glucokinase activity of the 'uninvolved' liver is diminished and that of hexokinase is increased. Comparison of rats at various times after the implantation of ascites tumor, mammary

Upregulation of glycolytic enzymes in proteins secreted from human colon cancer cells with 5-fluorouracil resistance.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

5-Fluorouracil (5-FU) is the most commonly used chemotherapeutic agent for colorectal cancer (CRC). However, resistance to this drug is a major obstacle in CRC chemotherapy. Accurate prediction of response to 5-FU would avoid unnecessary chemotherapy and allow the selection of other effective drugs.

Active and inactive metabolic pathways in tumor spheroids: determination by GC-MS.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

Active metabolic pathways in three-dimensional cancer-cell cultures are potential chemotherapeutic targets that would be effective throughout tumors. Chaotic vasculature creates cellular regions in tumors with distinct metabolic behavior that are only present in aggregate cell masses. To quantify

Epigenetic silencing of triple negative breast cancer hallmarks by Withaferin A.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

Triple negative breast cancer (TNBC) is characterized by poor prognosis and a DNA hypomethylation profile. Withaferin A (WA) is a plant derived steroidal lactone which holds promise as a therapeutic agent for treatment of breast cancer (BC). We determined genome-wide DNA methylation changes in

Estradiol stimulates the biosynthetic pathways of breast cancer cells: detection by metabolic flux analysis.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

Selective estrogen receptor (ER) modulators are highly successful breast cancer therapies, but they are not effective in patients with ER negative and selective estrogen receptor modulator (SERM)-resistant tumors. Understanding the mechanisms of estrogen-stimulated proliferation may provide a route

Induction of erythroid differentiation in human erythroleukemia cells by depletion of malic enzyme 2.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

Malic enzyme 2 (ME2) is a mitochondrial enzyme that catalyzes the conversion of malate to pyruvate and CO2 and uses NAD as a cofactor. Higher expression of this enzyme correlates with the degree of cell de-differentiation. We found that ME2 is expressed in K562 erythroleukemia cells, in which a

ME1 promotes basal-like breast cancer progression and associates with poor prognosis.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

Basal-like breast cancer (BLBC) is associated with a poor clinical outcome due to the few treatment options and absence of effective targeted agents. Here, we show that malic enzyme 1 (ME1) is dramatically upregulated in BLBC due to ME1 copy number amplification. ME1 expression increases glucose

Predchádzajúce
1
2
Ďalšie

Pripojte sa k našej
facebookovej stránke

Herbal & Natural Medicine

Najkompletnejšia databáza liečivých bylín podporovaná vedou

Pracuje v 55 jazykoch
Bylinné lieky podporené vedou
Rozpoznávanie bylín podľa obrázka
Interaktívna GPS mapa - označte byliny na mieste (už čoskoro)
Prečítajte si vedecké publikácie týkajúce sa vášho hľadania
Vyhľadajte liečivé byliny podľa ich účinkov
Usporiadajte svoje záujmy a držte krok s novinkami, klinickými skúškami a patentmi

Zadajte príznak alebo chorobu a prečítajte si o bylinách, ktoré by vám mohli pomôcť, napíšte bylinu a pozrite sa na choroby a príznaky, proti ktorým sa používa.
* Všetky informácie sú založené na publikovanom vedeckom výskume