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Development of a food compositional database for the estimation of dietary intake of phyto-oestrogens in a group of postmenopausal women previously treated for breast cancer and validation with urinary excretion.

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The scientific literature contains evidence suggesting that women who have been treated for breast cancer may, as a result of their diagnosis, increase their phyto-oestrogen (PE) intake. In the present paper, we describe the creation of a dietary analysis database (based on Dietplan6) for the

CYP17 genotype modifies the association between lignan supply and premenopausal breast cancer risk in humans.

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Cytochrome P450c17alpha (CYP17) has been associated with alterations in steroid hormone levels and premenopausal breast cancer risk and could modify the association between phytoestrogen intake and breast cancer risk. We examined plasma concentrations of enterolactone and genistein, estimated

Dietary intakes of total and specific lignans are associated with clinical breast tumor characteristics.

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Dietary lignans may affect breast cancer by modifying tumor characteristics likely to affect prognosis. We investigated usual dietary intakes of total and specific lignans with tumor characteristics in 683 women with breast cancer and 611 healthy women without breast cancer enrolled in the Data Bank

Dietary consumption of phytochemicals and breast cancer risk in Mexican women.

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OBJECTIVE To perform an evaluation of selected phytochemicals intake and breast cancer (BC) risk in Mexican women. METHODS We conducted hospital-based case-control study. METHODS Mexico City between 1994 and 1996. METHODS A total of 141 histologically confirmed BC cases were age-matched (+/-3 years)

Dietary lignan intakes and risk of pre- and postmenopausal breast cancer.

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Lignans are plant compounds metabolized in the mammalian gut to produce the phytoestrogens enterolactone and enterodiol. Because estrogens have been linked to breast cancer etiology, lignans could affect breast cancer risk through modulation of endogenous estrogen metabolism or competitive

Dietary lignan intake and postmenopausal breast cancer risk by estrogen and progesterone receptor status.

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BACKGROUND Studies conducted in Asian populations have suggested that high consumption of soy-based foods that are rich in isoflavone phytoestrogens is associated with a reduced risk of breast cancer. However, the potential associations of other dietary phytoestrogens--i.e., the lignans or their

Dietary phytoestrogen intake and premenopausal breast cancer risk in a German case-control study.

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A diet high in isoflavonoids (soy) is associated with lower breast cancer risk in Asian populations. Due to the low soy intake, dietary lignans may be the more important phytoestrogen class in Western populations. We used a population-based case-control study of breast cancer by age 50 in southern

Case-control study of phyto-oestrogens and breast cancer.

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BACKGROUND Phyto-oestrogens are a group of naturally occurring chemicals derived from plants; they have a structure similar to oestrogen, and form part of our diet. They also have potentially anticarcinogenic biological activity. We did a case-control study to assess the association between

Mammalian phytoestrogens: enterodiol and enterolactone.

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The mammalian phytoestrogens enterodiol (END) and enterolactone (ENL) are produced in the colon by the action of bacteria on the plant precursors matairesinol (MAT), secoisolariciresinol (SECO), their glycosides, and other precursors in the diet. Both END and ENL have been shown to possess weakly

Differential and directional estrogenic signaling pathways induced by enterolignans and their precursors.

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Mammalian lignans or enterolignans are metabolites of plant lignans, an important category of phytochemicals. Although they are known to be associated with estrogenic activity, cell signaling pathways leading to specific cell functions, and especially the differences among lignans, have not been

[Phytoestrogens].

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The soy-isoflavones genistein and daidzein and the flaxseed-lignans secoisolariciresinol and matairesinol belong to the group of phytoestrogens. Epidemiological data suggest that phytoestrogens have a preventive effect against various estrogen-related diseases/symptoms such as breast cancer,

The Structural Bioinformatics analysis of Biophenolic Lignan-Estrogen Receptor interaction.

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BACKGROUND Plant lignans have proven efficacious in blocking estrogen receptors of breast cancer cells. However, available studies have mostly dealt with anti-cancer effects of groups of lignans in certain foods or plants and the effects of specific lignans, especially from a molecular interaction

Dietary lignins are precursors of mammalian lignans in rats.

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The mammalian lignans enterolactone (ENL) and enterodiol, commonly found in human plasma and urine, are phytoestrogens that may contribute to the prevention of breast cancer and coronary heart disease. They are formed by the conversion of dietary precursors such as secoisolariciresinol and

Dietary seaweed modifies estrogen and phytoestrogen metabolism in healthy postmenopausal women.

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Seaweed and soy foods are consumed daily in Japan, where breast cancer rates for postmenopausal women are significantly lower than in the West. Likely mechanisms include differences in diet, especially soy consumption, and estrogen metabolism. Fifteen healthy postmenopausal women participated in

Phytoestrogen consumption from foods and supplements and epithelial ovarian cancer risk: a population-based case control study.

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BACKGROUND While there is extensive literature evaluating the impact of phytoestrogen consumption on breast cancer risk, its role on ovarian cancer has received little attention. METHODS We conducted a population-based case-control study to evaluate phytoestrogen intake from foods and supplements

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