nicotinic acid/seizures

Odkaz sa uloží do schránky

ČlánkyKlinické štúdiePatenty

Vyberte typ zoradenia

Strana 1 od 19 výsledky

Protective action of nicotinic acid benzylamide in a variety of chemically-induced seizures in mice.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

OBJECTIVE The study aims to assess the anticonvulsant effects offered by benzylamide nicotinic acid (Nic-BZA) in many animal models of chemically-induced seizures (i.e., pentylenetetrazole [PTZ], pilocarpine [PILO], bicuculline [BIC], α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid [AMPA],

[Tryptophan metabolism "via" nicotinic acid in children with febrile convulsions].

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

In silico validation and structure activity relationship study of a series of pyridine-3-carbohydrazide derivatives as potential anticonvulsants in generalized and partial seizures.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

A series of twelve compounds (Compounds RNH1-RNH12) of acid hydrazones of pyridine-3-carbohydrazide or nicotinic acid hydrazide was synthesized and evaluated for anticonvulsant activity by MES, scPTZ, minimal clonic seizure and corneal kindling seizure test. Neurotoxicity was also determined for

Anticonvulsant and acute neurotoxic characteristics of nicotinic acid benzylamide: a preclinical study.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

The aim of this study was to evaluate time-course and dose-response relationships of nicotinic acid benzylamide (Nic-BZA) with regard to its anticonvulsant activity in the maximal electroshock (MES)-induced seizures and acute neurotoxic effects in terms of motor coordination impairment in the

Assessment of the anticonvulsant potency of various benzylamide derivatives in the mouse maximal electroshock-induced seizure threshold model.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

OBJECTIVE The aim of this study was to assess the anticonvulsant potency of 6 various benzylamide derivatives [i.e., nicotinic acid benzylamide (Nic-BZA), picolinic acid 2-fluoro-benzylamide (2F-Pic-BZA), picolinic acid benzylamide (Pic-BZA), (RS)-methyl-alanine-benzylamide (Me-Ala-BZA),

Antagonism of seizures induced by the administration of the endogenous convulsant quinolinic acid into rat brain ventricles.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

The effect of pretreatment with drugs on generalized clonic-tonic seizures induced by intracerebroventricular (i.c.v.) administration of the endogenous convulsant quinolinic acid (QUIN, 50 micrograms) was studies in rats. Of the inhibitory amino acids tested, only 1-glycine (50 and 100 micrograms,

In vivo brain dialysis of amino acids and simultaneous EEG measurements following intrahippocampal quinolinic acid injection: evidence for a dissociation between neurochemical changes and seizures.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

The extracellular content of taurine, glutamate, glutamine, and glycine was measured by the novel method of brain dialysis in the acute phases following an intrahippocampal injection of the excitotoxic convulsant brain metabolite quinolinic acid (QUIN). Using bilaterally implanted depth electrodes

Nicotinamide, inosine and hypoxanthine, putative endogenous ligands of the benzodiazepine receptor, opposite to diazepam are much more effective against kynurenine-induced seizures than against pentylenetetrazol-induced seizures.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

Nicotinamide (NAM, 1000 mg/kg), inosine (INS, 1000 mg/kg), hypoxanthine (HXT, 500 mg/kg), putative endogenous ligands of the benzodiazepine receptor, and nicotinic acid (NA, 500 mg/kg) diminished DL-kynurenine-(DL-K, 50 micrograms ICV) induced seizures in C57BL/6 adult male mice and only prolonged

Vitamins in psychiatry. Do they have a role?

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

Deficiencies of specific vitamins produce consistent symptoms of psychiatric disorder. Thiamine deficiency, which is common in alcoholism, can produce confusion and psychotic symptoms, in addition to neurological signs. Vitamin B12 and folate deficiency may contribute symptoms of disorientation,

[Decrease in the activity of cerebral gamma-aminobutyric acid metabolism enzymes under the influence of kynurenines possessing convulsive activity].

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

Content of gamma-aminobutyric acid (GABA) was unaltered in mouse brain and cerebellum after administration of D,L-kynurenine (50 mcg), quinolinic acid (5 mcg) and nicotinic acid (50 mcg) into brain ventricles. At the same time, after administration of kinurenine, quinolinic acid and nicotinic acid

[Vitamins in metabolic diseases].

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

Several vitamins have been demonstrated to interfere with the pathogenesis of some metabolic diseases, mainly by three different mechanisms: 1) vitamin malabsorption, 2) errors in vitamin metabolism, 3) vitamin dependent syndromes. The latter is due to a deficiency of the apoenzyme whose coenzyme is

[Enhancement of the convulsant action of strychnine following administration of kynurenines into the cerebral ventricles of frogs].

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

In frogs (Rana temporaria) injection of L-kynurenine, quinolinic, nicotinic and picolinic acids (10 microgram) into brain ventricles potentiated the stimulant ad convulsant effects of a subthreshold dose of strychnine. Xanthurenic and anthranilic acids were ineffective. At a dose of 100 micrograms

Alcoholic Pellagra as a Cause of Altered Mental Status in the Emergency Department.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

BACKGROUND Pellagra, which is caused by a deficiency of niacin and tryptophan, the precursor of niacin, is a rare disease in developed countries where alcoholism is a major risk factor due to malnutrition and lack of B vitamins. Although pellagra involves treatable dementia and psychosis, it is

Studies on the potential neurotoxic and convulsant effects of increased blood levels of quinolinic acid in rats with altered blood-brain barrier permeability.

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

Intravenous injection of 450 mg/kg quinolinic acid (Quin), an endogenous kynurenine metabolite with excitotoxic properties, induced only minor electroencephalographic (EEG) modifications and no neurotoxicity in rats with a mature blood-brain barrier (BBB). BBB permeability was altered in rats by

[Stimulatory effects of intraventricular administration of kynurenines, amino acids, and convulsants: differences between rats and mice].

Články môžu prekladať iba registrovaní používatelia

Prihlásiť Registrácia

Quinolinic acid appeared to be the only kynurenine metabolite among tested (L- and DL-kynurenine sulfate, kynurenic and nicotinic acids, nicotinamide) which induced locomotor excitation and clonic seizures in rats whereas all of them exerted convulsant action in mice. Excitatory 1-glutamic and

Predchádzajúce
1
2
Ďalšie

Pripojte sa k našej
facebookovej stránke

Herbal & Natural Medicine

Najkompletnejšia databáza liečivých bylín podporovaná vedou

Pracuje v 55 jazykoch
Bylinné lieky podporené vedou
Rozpoznávanie bylín podľa obrázka
Interaktívna GPS mapa - označte byliny na mieste (už čoskoro)
Prečítajte si vedecké publikácie týkajúce sa vášho hľadania
Vyhľadajte liečivé byliny podľa ich účinkov
Usporiadajte svoje záujmy a držte krok s novinkami, klinickými skúškami a patentmi

Zadajte príznak alebo chorobu a prečítajte si o bylinách, ktoré by vám mohli pomôcť, napíšte bylinu a pozrite sa na choroby a príznaky, proti ktorým sa používa.
* Všetky informácie sú založené na publikovanom vedeckom výskume