octanol/atrofia

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11 výsledky

Octanol-water partition: searching for predictive models.

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The log n-octanol/water partition coefficient (log Po/w) still represents one of the most informative physicochemical parameters available to medicinal chemists. In the present work, principles, methodologies, and parameters are briefly reviewed for a variety of models developed to predict this

BIM EL-mediated apoptosis in cumulus cells contributes to degenerative changes in aged porcine oocytes via a paracrine action.

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Whether cumulus cells (CCs) contribute to oocyte aging remains controversial; in that regard, little is known about biochemical processes of gene expression in CCs surrounding aged oocytes. The objective was to elucidate contributions of CCs to porcine oocyte aging and degeneration, apoptosis and

Neurologic and histopathologic evaluation after high-volume intrathecal amitriptyline.

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OBJECTIVE Accumulating evidence indicates that amitriptyline decreases pain sensation when administered orally, intraperitoneally, or for sciatic nerve block. Previous reports of intrathecal administration of amitriptyline have yielded inconsistent results. The failure of amitriptyline to provide

Neuroprotective effects of tempol acyl esters against retinal ganglion cell death in a rat partial optic nerve crush model.

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OBJECTIVE The aim of this study is to search for more effective derivatives of the superoxide dismutase mimetic tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl). Although tempol is neuroprotective in a rat partial optic nerve crush (PONC) model, relatively high doses are required to exert

Three-dimensional structure/hydrophobicity of latarcins specifies their mode of membrane activity.

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Latarcins, linear peptides from the Lachesana tarabaevi spider venom, exhibit a broad-spectrum antimicrobial activity, likely acting on the bacterial cytoplasmic membrane. We study their spatial structures and interaction with model membranes by a combination of experimental and theoretical methods

Characterization of three propane-inducible oxygenases in Mycobacterium sp. strain ENV421.

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OBJECTIVE Mycobacterium sp. strain ENV421 has the ability to cometabolize a variety of chemicals following growth on propane as a sole source of carbon and energy. In this study, we used genetic and biochemical approaches to identify and characterize multiple propane-inducible oxygenase genes in

Spatial structure and activity mechanism of a novel spider antimicrobial peptide.

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Latarcins (Ltc), linear peptides (ca. 25 amino acid long) isolated from the venom of the Lachesana tarabaevi spider, exhibit a broad-spectrum antibacterial activity, most likely acting on the bacterial plasmatic membrane. We study the structure-activity relationships in the series of these

Rapid separation of free fatty acids in vegetable oils by capillary zone electrophoresis.

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BACKGROUND Olive oil is a very important product to human health since it inhibits formation of free radicals, tumour growth, lesions and inflammatory substances. High concentrations of free fatty acids in olive oils results in lipid deterioration due to oxidative or hydrolytic

Liquid-liquid extraction and flat sheet supported liquid membrane studies on Am(III) and Eu(III) separation using 2,6-bis(5,6-dipropyl-1,2,4-triazin-3-yl)pyridine as the extractant.

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Solvent extraction and supported liquid membrane transport studies for the preferential removal of Am(3+) from feeds containing a mixture of Am(3+) and Eu(3+) was carried out using 2,6-bis(5,6-dipropyl-1,2,4-triazin-3-yl)pyridine (n-Pr-BTP) as the extractant. Diluent plays an important role in these

Imaging hindered rotations of alkoxy species on TiO(2)(110).

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We present the first scanning tunneling microscopy (STM) study of the rotational dynamics of organic species on any oxide surface. Specifically, variable-temperature STM and dispersion-corrected density functional theory (DFT-D) are used to study the alkyl chain conformational disorder and dynamics

Polyacrylate-water partitioning of biocidal compounds: enhancing the understanding of biocide partitioning between render and water.

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In recent years, the application of polymer-based renders and paints for façade coatings of buildings has risen enormously due to the increased mounting of thermal insulation systems. These materials are commonly equipped with biocides - algaecides, fungicides, and bactericides - to protect the

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