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11 výsledky
[Effect of n-octanol on acute experimental pulmonary edema].
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Effects of nonsteroidal antiinflammatory drugs on the proton exchange reaction between octanol and water: its correlation with their inhibitions of inflammation and prostaglandin synthesis.
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Effect of various antiinflammatory drugs on proton exchange between octanol OH and water after partition equilibrium between octanol and water at pH 7.4 was examined. These drugs accelerated the proton exchange reaction to different extents. The rate constant of the proton exchange induced by the
Oxaliplatin-induced neurotoxicity is mediated through gap junction channels and hemichannels and can be prevented by octanol.
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Oxaliplatin-induced neurotoxicity (OIN) is a common complication of chemotherapy without effective treatment. In order to clarify the mechanisms of both acute and chronic OIN, we used an ex-vivo mouse sciatic nerve model. Exposure to 25 μM oxaliplatin caused a marked prolongation in the duration of
α-Pinene, linalool, and 1-octanol contribute to the topical anti-inflammatory and analgesic activities of frankincense by inhibiting COX-2.
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BACKGROUND
Frankincense oil and water extracts (FOE, FWE) have long been used for external treatment of inflammation and pain. The present study was conducted to identify the active ingredients responsible for the anti-inflammatory and analgesic effects and to determine the underlying
Developmental circulatory failure caused by metabolites of organophosphorus flame retardants in zebrafish, Danio rerio.
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Organophosphate triesters are used worldwide as additives in flame retardants and plasticizer as a replacement of polybrominated diphenyl ethers. Increasing evidence on human exposure to and environmental contamination with organophosphorus flame retardants (OPFRs) requires an adequate toxicity
Pulmonary accumulation of propranolol in vivo: sites and physiochemical mechanism.
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Despite the therapeutic importance of propranolol and the potential usefulness of propranolol extraction measurements for the assessment of lung disorders, the pulmonary disposition of propranolol remains poorly understood. The extraction, accumulation and distribution of propranolol in lungs of
[Effect of beta-glycyrrhizinate on eye mucosa absorption of drugs].
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Dipotassium beta-glycyrrhizinate (GK2) is a saponin originated from "kanzo" plant. We studied such two functions of GK2 as a drug carrier and a penetration enhancer on the eye mucosa. The interactions of GK2 with various drugs were investigated using the 1-octanol/water partition method. GK2
Predictability of the clinical potency of NSAIDs from the preclinical pharmacodynamics in rats.
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OBJECTIVE
Relevance of the preclinical pharmacodynamic, toxicity and pharmacokinetic parameters predicting the clinical potency of nonsteroidal antiinflammatory drugs (NSAIDs) was evaluated.
METHODS
Data for oral potencies of 24 NSAIDs in rats were collected from the literature and from New Drug
Hemichannel-mediated volume regulation contributes to IPC-induced cardiomyocyte protection.
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Cx43 has been documented to be involved in ischemic preconditioning (IPC). However, the participation of Cx43-formed hemichannels in IPC and the potential underlying mechanisms remain unclear. The present study focused on cardiomyocytes' volume regulation during IPC to investigate the role of
Steroidal anti-inflammatory antedrugs: synthesis and pharmacological evaluation of 16 alpha-alkoxycarbonyl-17-deoxyprednisolone derivatives.
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In a continuing effort to minimize the systemic adverse effects of potent anti-inflammatory steroids, a series of 16 alpha-alkoxycarbonyl-17-deoxyprednisolone derivatives: methyl (8a), ethyl (8b), isopropyl (8c), and benzyl (8d) 11 beta,21-dihydroxy-3,20-dioxo-1,4-pregnadiene-16 alpha-carboxylate,
Topical anti-inflammatory activity of esters of steroid 21-oic acids.
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Prednisolone derivatives, methyl 20 alpha- and 20 beta-dihydroprednisolonate and methyl 17,20 alpha- and 17,20 beta-acetonidodihydroprednisolonate have been evaluated for their topical anti-inflammatory activity in the croton oil induced ear edema test. The order of anti-inflammatory potency was
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