Disclosed are peptides having biological and therapeutic activity. Particularly disclosed are lipidated di- or tri-peptides analogs of KPV or KdPT that exhibit antimicrobial activity. In particular, the peptides of this invention provide enhanced anti-microbial activity over the base tri-peptides, lysine-proline-valine and lysine-d-proline-tyrosine. The disclosed peptides have the general formula of C12-18 lipid-KXZ-NH.sub.2i wherein K is lysine; X is proline, d-proline, histidine or arginine; Z is optional and if present Z is valine, threonine, alanine or leucine; and the terminal COOH is NH.sub.2 amidated. The C12-18 lipid is preferably the lipid moiety of lauric acid (C12), myristic acid (C14), pentadecanoic acid (C15), palmitic acid (C16), or stearic acid (C18). The invention is further related to methods of using of these peptides to treat various insults, inflammations or bacterial infections affecting the skin and other related mucosal body surfaces such as the oral cavity.

Helix BioMedix Inc.

HELIX BIOMEDIX, INC

Short antimicrobial lipopeptides

The present invention relates to a novel oil extracted from the seeds of Momordica charantia L., for topical application to a body of mammal and used as anti-inflammatory, anti-arthritic, vasculodilatory and wound healing agent, said oil essentially comprising capric acid 0.7-1.2% by wt., lauric acid 0.6-1% by wt., palmitic acid 42-5.0% by wt., stearic acid 59-62% by wt., oleic acid 13-15% by wt., archid acid 3-5% by wt., linoleic acid 8-10% by wt., and other undetected minor acids 6-8% by wt.; and a process for producing such oil.

palmitic acid/zápal

Short antimicrobial lipopeptides

Oil from Momordica charantia L., its method of preparation and uses

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