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14 výsledky
The administration of papain buccally in the treatment of inflammation and edema.
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Inhibition of tumor growth, invasion and metastasis in papain-immunized mice.
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Papain-immunized mice possess serum antibodies which cross-react with cathepsin-B- and cathepsin-H-like endopeptidases isolated from B16 melanoma cells. The growth rate, invasion and metastasis of both the B16 melanoma and the Lewis lung carcinoma were inhibited in mice immunized with papain. These
The C-terminus of murine S100A9 inhibits hyperalgesia and edema induced by jararhagin.
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The effect of a synthetic peptide (H92-G110) identical to the C-terminus of murine S100A9 (mS100A9p) was investigated on hyperalgesia and edema induced by either jararhagin or papain in the rat paw. mS100A9p not only reverted hyperalgesia and edema induced by jararhagin, but also the highest
[Effectiveness Of 2% And 4% Papain Gels In The Healing Of Venous Ulcers].
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OBJECTIVE
To analyze the effectiveness of 2% and 4% papain gels in tissue repair of venous ulcers.
METHODS
Quasi-experimental study with consecutive sample of 16 patients with 30 venous ulcers treated at the outpatient clinic of a teaching hospital, from April to November in 2011, using a form for
Anti-inflammatory activity of Bromelia hieronymi: comparison with bromelain.
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Some plant proteases (e. g., papain, bromelain, ficin) have been used as anti-inflammatory agents for some years, and especially bromelain is still being used as alternative and/or complementary therapy to glucocorticoids, nonsteroidal antirheumatics, and immunomodulators. Bromelain is an extract
Faulty healing in the lower extremities; vascular deficiency as a complication in industrial injuries.
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The failure of injuries of the lower extremities to heal properly can often be traced in older persons to arteriosclerosis obliterans. In industry this condition presents a serious problem to older workers, to employers and to insurance carriers. In persons with severe varicosis or those who have
Vascular and interstitial mechanics in canine pulmonary emphysema.
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We examined the changes in vascular and interstitial mechanics in pulmonary emphysema (PE) using a canine lobar model. PE was produced in the left lower lobe (LLL) of five dogs (group E) by six weekly intrabronchial instillations of the enzyme papain. In five control dogs (group C), a normal saline
[Effect of platelet-rich plasma on synovitis of rabbit knee].
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OBJECTIVE
Platelet-rich plasma (PRP) can promote the repair of soft tissue, wound, and bone defect. To investigate the effect of PRP on synovitis by establishing papain-induced osteoarthritis model of rabbit knee and interfering with PRP.
METHODS
Twenty healthy 6-month-old rabbits (male or female,
Physico-chemical characterization and pharmacological activities of sulfated polysaccharide from sea urchin, Paracentrotus lividus.
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Sulfated polysaccharide (SP) from the eggs of sea urchin Paracentrotus lividus, extracted by papain digestion, was characterized by size exclusion chromatography coupling on-line with light scattering and viscosity detectors (SEC/MALS/VD/DRI), gas chromatography coupled to mass spectrometer (GC-MS),
Chemical Structure, Anti-Inflammatory and Antinociceptive Activities of a Sulfated Polysaccharide From Gracilaria Intermedia Algae
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The present work aimed at carrying out the isolation and biochemical characterization of a sulfated polysaccharide fraction (PLS) from the marine algae Gracilaria intermedia and investigating its anti-inflammatory and antinociceptive potential. PLS was obtained through enzymatic digestion with
Healing process in mice model of surgical wounds enhanced by Phyllocaulis boraceiensis mucus.
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OBJECTIVE
Phyllocaulis boraceiensis mucus has been studied as a potential source of new natural compounds that are capable of inducing proliferation and remodeling tissue. The aim of this study was to evaluate the clinical aspects of healing in the wounded mouse skin, which was treated with an
Peptide aldehyde inhibitors of cathepsin K inhibit bone resorption both in vitro and in vivo.
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We have shown previously that cathepsin K, a recently identified member of the papain superfamily of cysteine proteases, is expressed selectively in osteoclasts and is the predominant cysteine protease in these cells. Based upon its abundant cell type-selective expression, potent endoprotease
Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity.
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The proteasome regulates cellular processes as diverse as cell cycle progression and NF-kappaB activation. In this study, we show that the potent antitumor natural product epoxomicin specifically targets the proteasome. Utilizing biotinylated-epoxomicin as a molecular probe, we demonstrate that
Endothelium-dependent and endothelium-independent vasorelaxant effects of unripe Rubus coreanus Miq. and Dendropanax morbiferus H. Lév. extracts on rat aortic rings
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Background: Many clinical trials on antihypertensive drugs have confirmed the usefulness of these drugs in regulating blood pressure effectively. However, all the drugs usually require long-term use; thus, economic burdens as well as some
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