prunella orientalis/protiplesňový

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Network pharmacology based virtual screening of active constituents of Prunella vulgaris L. and the molecular mechanism against breast cancer

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Prunella vulgaris L, a perennial herb widely used in Asia in the treatment of various diseases including cancer. In vitro studies have demonstrated the therapeutic effect of Prunella vulgaris L. against breast cancer through multiple pathways. However, the nature of the biological mechanisms remains

[Involvement of JNK and caspase-3 in human lymphoma cell apoptosis induced by Prunella vulgaris].

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OBJECTIVE To characterize the effect of Prunella vulgaris upon lymphoma cells and its possible mechanisms. METHODS Raji cells were subjected to different therapeutic schemes: Prunella vulgaris (50 g/L) group, P. vulgaris (50 g/L)+SP600125 (20 micromol/L, JNK inhibitor) (SP600125 group); Raji cells

Effect of Prunella vulgaris polysaccharides on cultured orbit fibroblasts in vitro from patients with thyroid-associated ophthalmopathy

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To observe the effect of Prunella vulgaris polysaccharides (PVP) on cultured orbit fibroblasts in vitro from patients with thyroid-associated ophthalmopathy (TAO). PVP at different concentrations were used to treat different groups of fibroblasts from TAO patients and normal persons. Dexamethasone

Inhibitory Effects of Prunella vulgaris L. Extract on 11β-HSD1 in Human Skin Cells.

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Glucocorticoids are a risk factor for age-induced skin structure and function defects, and the glucocorticoid-activating enzyme, 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), represents a promising therapeutic target. Prunella vulgaris L. (PV) is a perennial and an edible herbaceous plant normally

Effect of polyacetylenic acids from Prunella vulgaris on various plant pathogens.

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OBJECTIVE This study is aiming at characterizing antifungal substances from the methanol extract of Prunella vulgaris and at investigating those substances' antifungal and antioomycete activities against various plant pathogens. RESULTS Two polyacetylenic acids were isolated from P. vulgaris as

Prunella vulgaris L. active components and their hypoglycemic and antinociceptive effects in alloxan-induced diabetic mice.

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Prunella vulgaris L. (Lamiaceae) (PV) is a herbaceous plant traditionally utilized in management of diabetes and it has immunomodulatory activity. In this study, acute and subchronic antidiabetic, in-vivo antioxidant and antinociceptive effects of PV were evaluated in alloxan-induced type 1 diabetes

Effect of SKI 306X, a new herbal anti-arthritic agent, in patients with osteoarthritis of the knee: a double-blind placebo controlled study.

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SKI 306X is a purified extract from a mixture of three oriental herbal medicines (Clematis mandshurica, Trichosanthes kirilowii and Prunella vulgaris) that have been widely used for the treatment of inflammatory diseases such as lymphadenitis and arthritis in far East Asia. A double-blind,

Ursolic acid from Prunella vulgaris L. efficiently inhibits IHNV infection in vitro and in vivo.

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Infectious hematopoietic necrosis virus (IHNV) is a fish viral pathogen that causes severe disease and huge economic losses in the salmonid aquaculture industry. However, anti-IHNV drugs currently are scarce. For the purpose of seeking out anti-IHNV drugs, the anti-IHNV activities of 32 medicinal

[Molecular mechanism of Prunella vulgaris in alleviating autoimmune hepatitis in mice]

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Objective To observe the therapeutic effects of Prunella vulgaris on autoimmune hepatitis (AIH) in mice and explore its mechanism. Methods Forty C57BL/6 mice were randomly divided into normal group, AIH model group and 50, 100 and 200 mg/kg Prunella vulgaris-treated AIH groups with 8 mice each. AIH

[Textual research on original plant and dietotherapy history of Prunella vulgaris].

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OBJECTIVE To investigate the original plant and dietotherapy history of Prunella vulgaris by textual researches, and provide a theoretical basis for clinical medication, exploitation and protection of wild resources. METHODS The ancient literatures in the graphic, geographical distribution and

Effect of Chinese herbal medicine extracts on cell-mediated immunity in a rat model of tuberculosis induced by multiple drug-resistant bacilli.

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Drug-resistant Mycobacterium tuberculosis poses a major threat to public health. The present study aimed to investigate the effects of Radix Ranunculi Ternati, Radix Sophorae Flavescentis, Prunella Vulgaris L. and Stellera Chamaejasme L. extracts on cell‑mediated immunity in a rat model of

Oleanolic acid regulates NF-κB signaling by suppressing MafK expression in RAW 264.7 cells.

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Oxidative stress and inflammation are common to many pathological conditions. Defense mechanisms protect cells from oxidative stress, but can become over-activated following injury and inflammation. NF-κB and Nrf2 transcription factors regulate proinflammatory and antioxidant gene expression,

In vitro assessment of selected Korean plants for antioxidant and antiacetylcholinesterase activities.

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BACKGROUND Antiacetylcholinesterase (AChE) drugs have been a main therapeutic treatment for Alzheimer's disease because increased AChE levels play a key role in reducing neurotransmission. OBJECTIVE Extracts from 35 Korean plants were selected and screened for antioxidant and anti-cholinesterase

A tyrosine aminotransferase involved in rosmarinic acid biosynthesis in Prunella vulgaris L.

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Rosmarinic acid (RA) and its derivants are medicinal compounds that comprise the active components of several therapeutics. We isolated and characterised a tyrosine aminotransferase of Prunella vulgaris (PvTAT). Deduced PvTAT was markedly homologous to other known/putative plant TATs. Cytoplasmic

Biosynthesis of antioxidative enzymes and polyphenolics content in calli cultures of Prunella vulgaris L. in response to auxins and cytokinins

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Prunella vulgaris L. is one of the therapeutic herbs containing various polyphenolics, which is used for multiple medicinal purposes. In this study, plant growth regulators (PGRs)-induced calli cultures from seed-derived leaf explants were exploited for the production of stress enzymes and

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