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Strana 1 od 35 výsledky
Therapeutic effect of psoralen on muscle atrophy induced by tumor necrosis factor-α.
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Actinic degeneration and pigmentary change in association with psoralen and UVA treatment: a 20-year prospective study.
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BACKGROUND
Changes in the appearance of the skin including actinic degeneration and pigmentary changes have been noted in patients treated with psoralen and UVA (PUVA).
OBJECTIVE
Our purpose was to quantify risk factors for increased extent and progression of actinic degeneration and pigmentary
Effects of psoralen on chondrocyte degeneration in lumbar intervertebral disc of rats.
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Discuss the internal mechanism of delaying degeneration of lumber intervertebral disc. The cartilage of lumbar intervertebral disc of SD rats was selected in vitro, then cultured by tissue explant method, and identified by HE staining, toluidine blue staining and immunofluorescence. The optimal
Histologic alterations of psoralen- and longwave ultraviolet radiation-exposed skin.
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Histologic changes in skin exposed to psoralen photochemotherapy (PUVA) may be classified as acute or chronic. The acute set of histologic alterations includes changes associated with lesion regression and PUVA toxicity. The chronic set of changes related primarily to the side effects of PUVA
Treatment of necrobiosis lipoidica with topical psoralen plus ultraviolet A.
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BACKGROUND
Necrobiosis lipoidica (NL) is a rare skin disease, mostly seen on the legs and often occurring in patients with diabetes mellitus. The disease belongs to the idiopathic cutaneous palisading granulomatous dermatitides associated with a degeneration of collagen, thus leading to skin
Evaluation of psoralen with solar ultraviolet light (puvasol) and adjunctive topical tar therapy in psoriasis.
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Fifty patients having psoriasis were studied with a view to assess the efficacy of 'puvasol' (Oral psoralen with sun-rays exposure) alone and in combination with topical tar therapy and were placed in 2 groups, each group being consisted of 25 patients. At the end of 8 weeks, out of 25 patients
Chronic cutaneous effects of long-term psoralen and ultraviolet radiation therapy in patients with vitiligo.
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Vitiligo is refractory to most therapeutic modalities. To assess the efficacy of a variety of PUVA therapies, we enrolled 596 subjects in a prospective study, and 230 were followed for up to 55 months. Various psoralen derivatives and dosage schedules were used. Each subject was examined at yearly
Extracellular granular material and degeneration of keratinocytes in the normally pigmented epidermis of patients with vitiligo.
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Multiple biopsy specimens from the skin of 28 patients with common vitiligo were examined by light and electron microscopy. The patients were grouped according to the activity of their disease: progressing, stable, repigmenting, and resistant to treatment with psoralen plus sunlight. Three biopsy
[An experimental study on antitumor activity of psoralen on mammary cancer cell line EMT6 in vitro and in vivo].
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To investigate the antitumor activity of psoralen on mammary cancer cells of EMT6 line, the cytotoxity of the drug against EMT6 cells was tested by MTT assay; an experimental therapy was carried out in 15 nude mice that were subcutaneously injected with EMT6 cells; the morphological changes of tumor
Antitumor activity of psoralen on mucoepidermoid carcinoma cell line MEC-1.
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Psoralen (PSO) was found cytotoxic against in vitro cultured human mucoepidermoid carcinoma cells of MEC-1 cell line. Its IC50 value was 8.6 micrograms/ml, and relative antitumor activity (RAA) 15. PSO suppressed DNA synthesis, damaged microvilli and cell membrane, and induced degeneration of
Intersystem crossing driven by vibronic spin-orbit coupling: a case study on psoralen.
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For 7H-furo[3,2-g][1]benzopyran-7-one (psoralen), intersystem crossing (ISC) rate constants have been computed. Employing the Fermi golden rule, the harmonic approximation, and a pure-spin Born-Oppenheimer basis, both direct and vibronic spin-orbit (SO) coupling has been taken into account.
Psoralen plus UVA vs. UVB-311 nm for the treatment of lichen planus.
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BACKGROUND
The purpose of this study was to evaluate and compare the short- and long-term therapeutic efficacy of psoralen plus UVA (PUVA) vs. UVB-311 nm in the treatment of patients with disseminated lichen planus.
METHODS
A computerized data bank search and chart review revealed that data from a
Psoralen stimulates osteoblast differentiation through activation of BMP signaling.
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Osteoporosis is a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture. In order to improve the treatment of osteoporosis, identification of anabolic and orally
Psoralen Protects Chondrocytes, Exhibits Anti-Inflammatory Effects on Synoviocytes, and Attenuates Monosodium Iodoacetate-Induced Osteoarthritis.
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Current study examined whether psoralen (PSO) exhibits anti-inflammatory responses, protection and activation of chondrocytes, and relieve osteoarthritis (OA). Rats chondrocytes and human synoviocytes were cultured in tumor necrosis factor-α (TNF-α) conditioned culture medium with/without PSO to
Treatment of oral chronic graft-versus-host disease with PUVA therapy: case report and literature review.
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Chronic graft-versus-host disease commonly appears with oral manifestations subsequent to allogeneic bone marrow transplantation. These manifestations include leukoplakia, mucosal atrophy, erythema, ulcers, and xerostomia. Some lesions are resistant to treatment with immunosuppressive medications.
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