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[Determination of tumor biological parameters in breast cancer: round robin testing for quality assurance].

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Round robin testing for quality assurance in the determination of the breast cancer biomarkers estrogen receptor (ER), progesterone receptor (PR) and epithelial growth factor receptor 2 (HER2) have been carried out in Germany for 13 years. As the first quality assurance trial worldwide tissue

[ErbB2 diagnostics in breast cancer--an update].

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Determining ErbB2/Her-2/neu status has become an essential part of breast cancer diagnosis and a prerequisite before considering a patient's eligibility for treatment with trastuzumab. Currently the most common techniques to assess ErbB2 status in routine practice are the identification of receptor

Health care services use among long-term breast cancer survivors: a systematic review.

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Long-term breast cancer survivors are women surviving at least 5 years after diagnosis. This systematic review aimed to summarize the main characteristics and patterns of healthcare service use (frequency of visits, health providers visited, and preventive care performed) among

[Gene expression analysis in breast cancer. A new diagnostic tool in pathology].

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Molecular biomarker analysis is increasingly being used as a basis for individualized therapy selection. In breast cancer established standard biomarkers are hormone receptors, HER2 and if indicated Ki67. In particular for hormone receptor positive, HER2 negative tumors, gene expression analysis

Understanding sarcomas and other rare tumors: an interview with Robin L Jones.

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Robin L Jones speaks to Jade Parker, Commissioning Editor: Robin Jones is a medical oncologist specializing in the treatment of bone and soft tissue sarcomas and Head of the Sarcoma Unit at The Royal Marsden. He completed his medical training at Guy's and St Thomas' Hospital, and his oncology

Pierre Robin sequence associated with first trimester fetal tamoxifen exposure.

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Tamoxifen is a nonsteroidal antiestrogen used as the current adjuvant endocrine treatment of choice for premenopausal women treated for breast cancer and its potential for causing fetal harm during pregnancy remains inconclusive. While the evidence of tamoxifen's effects on humans in utero is

Prognostic value of tumor-infiltrating lymphocytes in patients with triple-negative breast cancer: a systematic review and meta-analysis.

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BACKGROUND

The objective of this systematic review and meta-analysis was to determine the prognostic value of total tumor-infiltrating lymphocytes (TILs) and subtypes of TILs (CD4⁺, CD8⁺, and FOXP3⁺) in triple-negative breast cancer

Cadmium exposure and risk of breast cancer: A dose-response meta-analysis of cohort studies

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Background: Cadmium is a toxic heavy metal that has been implicated in breast cancer etiology, albeit with inconsistent results. Objective: To investigate the shape of the

Effects of exercise on physical outcomes of breast cancer survivors receiving hormone therapy - A systematic review and meta-analysis

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Background: Side-effects of hormone therapy can impair the physical health of breast cancer survivors. Exercise has been clearly shown to improve the quality of life of breast cancer survivors. Less is known about the effects of exercise

Artificial neural networks in mammography: application to decision making in the diagnosis of breast cancer.

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The authors investigated the potential utility of artificial neural networks as a decision-making aid to radiologists in the analysis of mammographic data. Three-layer, feed-forward neural networks with a back-propagation algorithm were trained for the interpretation of mammograms on the basis of

Evaluation of computer-aided diagnosis on a large clinical full-field digital mammographic dataset.

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OBJECTIVE To convert and optimize our previously developed computerized analysis methods for use with images from full-field digital mammography (FFDM) for breast mass classification to aid in the diagnosis of breast cancer. METHODS An institutional review board approved protocol was obtained, with

An analytic method for randomized trials with informative censoring: Part 1.

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Consider a randomized trial in which time to the occurrence of a particular disease, say pneumocystis pneumonia in an AIDS trial or breast cancer in a mammographic screening trial, is the failure time of primary interest. Suppose that time to disease is subject to informative censoring by the

An analytic method for randomized trials with informative censoring: Part II.

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Consider a randomized trial in which time to the occurrence of a particular disease, say pneumocystic pneumonia in an AIDS trial or breast cancer in a mammographic screening trial, is the failure time of primary interest. Suppose that time to disease is subject to informative censoring by the

Estimating benefits of screening from observational cohort studies.

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Analysis and interpretation of observational studies of screening effectiveness is difficult because several biases threaten validity, including the structural healthy screenee bias, length bias, and effects of lead time. Although methods for the analysis of observational studies of screening

[HER2 testing and targeted therapy in advanced gastric cancer].

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A large phase III study on the use of the HER2 antibody trastuzumab in locally advanced or metastatic gastric cancer has now been completed. Patients whose tumors were either scored on immunohistochemistry (IHC) as 3+ (independently of the result of fluorescence in situ hybridization (FISH)) or as

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